BackgroundAngiotensin-converting enzyme (ACE) inhibitors-related cough had been reported to contribute for discontinuation of ACE inhibitors therapy. The role of ACE I/D and bradykinin B2 receptor T/C genes in ACE inhibitors-related cough is still unclear.

Thromboxane A2 is a potent vasoconstrictor and a stimulus of platelet aggregation, which may contribute to hypercoagulability. The prostacyclin, prostaglandin 12, has exactly the opposite effect. Measurement of the major urinary metabolites, 11-dehydro-thromboxane B2 and 2,3-dinor-6-ketoprostagl...

Phospholipase A2 is a known aggravator of inflammation and deteriorates neurological outcomes after traumatic brain injury (TBI), however the exact inflammatory mechanisms remain unknown. This study investigated the role of bradykinin and its receptor, which are known initial mediators within in...

An analytical method utilizing liquid chromatography coupled to mass spectrometry with electrospray ionization has been developed for the identification of prostaglandins (PGs) in cerebral tissues. The five compounds identified (thromboxane B2, prostaglandin E2, prostaglandin D2, 6-keto-prostagl...

ObjectiveHigh urinary Prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) levels have been reported in lupus nephritis (LN). Captopril diminishes proteinuria and improves glomerular filtration rate (GFR), and may have effect on immune function. We evaluate captopril effect on urinary PGE2, and TxB2.

BackgroundVarious inflammatory eicosanoid levels in biomaterials from airways of asthma and their associations with clinical parameters remain uncertain. We hypothesized that prostaglandin and leukotriene levels differ between in exhaled breath condensates (EBCs) and in sputum in mild, moderate,...

Nitroarylmethyl quaternary (NMQ) ammonium salts of the basic DNA intercalator AMAC (N,N-dimethylaminoethyl-9-amino-5-methylacridine-4-carboxamide) are of interest as anticancer prodrugs. A sensitive HPLC assay has been developed for quantitation of AMAC and its NMQ prodrugs in cultured cells, pl...

The synthesis of [N-MeA]2[M(mnt)2] (N-MeA=N-methylacridine; M=Ni (II), Zn (II), Cu (II) and Cd (II); mnt=maleonitriledithiolate) and crystal structure analysis of the Ni (1) and Zn (2) complexes are reported. The conductivities of almost all the complexes under 4 MPa pressure are above 10−5 S cm...

The sensitivity of catfish, Ictalurus punctatus, brain ATPase activities to cyclodiene compounds was investigated. The ATPase system showed differences in sensitivity to aldrin, dieldrin and photodieldrin. However, aldrin-transdiol (a more terminal metabolite of dieldrin and reported as a more p...

Metabolism, excretion, and body distribution of [14C]photodieldrin were studied in the rhesus monkey (Macaca mulatta) after single intravenous and repeated oral administration. After iv administration about 45 and 34% of the dose were excreted by the male and the female, respectively, during 21 ...

Doses of 1.5, 3.0, and 6.0 mg/kg/day of dieldrin and 0.15, 0.30, and 0.60 mg/kg/day of photodieldrin were administered to pregnant CD-1 mice and CD rats by gastric intubation on days 7–16 of gestation. The highest dose of dieldrin induced significant increases in liver/body weight ratios and re...

1. Dieldrin, a potent residual insecticide and common contaminant of the environment, is metabolized in liver and kidney of broiler to photodieldrin, a photoisomer of dieldrin.2. This metabolite has by gas-liquid chromatography (g.l.c.) analysis a retention time different to the aldrin.3. The an...

The subchronic toxicity of photodieldrin, a photodecomposition product of dieldrin which is found as a residue on certain agricultural commodities treated with dieldrin, was investigated in a 90-day feeding study in the rat. Comparison of the toxic potential of photodieldrin and dieldrin showed ...

Bluegill fish, following exposure to [14C]photodieldrin eliminated 50% of the absorbed radioactivity in 3 weeks. Analysis of the products revealed that about 27% of the eliminated radioactivity was due to the unaltered photodieldrin while the rest consisted of at least 11 metabolites in free and...

Goldfish (Carassius auratus) exposed to 20 parts per billion [14C]photodieldrin in a static system absorbed 80% of the radioactivity within 20 hr. The absorbed radioactivity was eliminated slowly with a half-life of 3 weeks. Photodieldrin and a ketone derivative were the major form of the radioc...

The oxidative coupling of 2,6-di-methylphenol is an industrial reaction catalyzed by the copper(II)-di-tert-butylethylenediamine-dibromo complex. In order to get more insight about the behavior of the N,N′-dialkyl-diamine cupric complexes and the halide effect on the catalyic activity, a spectr...

The binding of an antiestrogen with the uterine estrogen receptor (R) has been studied directly in vitro using [3H]dimethylstilbestrol (DMS). The affinity of DMS for R as determined at equilibrium was similar to that of estradiol (E2) (KD ∼- 0.3 nM) when taking into account the higher nonspecif...

A dose of dimethylstilbestrol, which is anti-estrogenic when given as a single intravaginal injection, produces all the vaginal changes characteristic of estrogen action when given as 1 or 2 series of 10 1-hourly injections. Similar results were obtained with 16-oxo-estradiol given in 1 or 2 ser...

Morphiceptin (Tyr-Pro-Phe-Pro-NH2) is a selective ligand of the mu opioid receptor, an important target in pain regulation. In this study, morphiceptin was modified at positions 2 or 3 by introduction of β2- or β3-amino acids and additionally in position 1 by replacing Tyr by Dmt (2′,6′-dime...

A synthetic strategy for resolving diastereoselective imperfections associated with using a chiral auxiliary has been designed. The, impact of this imperfection is a lower enantiomeric purity of the final product.A solution for the synthesis of Naproxen 1, an important antiinflammatory drug, usi...