The crystal structures of the diastereomeric esters prepared from (S)-2-methoxy-2-(1-naphthyl)propanoic acid [(S)-MαNP acid] and (R)-1-octen-3-ol or (S)-β-ionol were analyzed using X-ray crystallography. The conformation of the MαNP moiety determined from NMR analyses was observed in the crys...

PurposeAutophagy play an important role in tumor chemotherapy resistance. It has been reported that miR-137 expression was reducedand involved in the regulation of sensitivity of PC cells to chemotherapy. However, little is known about the underlying molecular mechanisms. In this study, we hypot...

The oncogene c-kit plays a vital role in the pathogenesis of acute myeloid leukemia (AML). However, the mechanism of microRNAs targeting c-kit in AML has not been determined in detail. Moreover, the role miR-137 in tumor cell proliferation remains controversial. The aim of this work was to verif...

GC-MS is the method of choice for toxicological analysis of toxicants volatile in GC while non-volatile and/or thermally labile toxicants need LC-MS for their determination. Studies are presented on the toxicological detection of the amphetamine-like anorectic clobenzorex in urine by GC-MS after...

Clobenzorex, an optically active N-substituted derivative of (+)amphetamine, has been identified on the illicit market. Because so little is known regarding the pharmacology or abuse potential of this agent, it was examined in tests of stimulus generalization in rats trained to discriminate 1 mg...

NMR spectra and basic equilibration of cis and trans methyl-3-isopropylcyclobutanecarboxylate are reported. Treatment of the nonplanar cyclobutane system by analogy with cyclohexane is potentially possible, but limited by (1) greater dependence of ring puckering on substituents; and (2) interven...

An efficient and easy one-pot reaction from readily available racemic 2-substituted cyclobutanones gave, by means of asymmetric Strecker synthesis in the presence of an amine chiral auxiliary, two major aminonitriles with excellent diastereoselectivity. After separation, the major cis-aminonitri...

4,4′-Vinylenedipyridine bis[2,2′ : 6′,2″-terpyridine platinum(II)], a potential intermolecular bis-intercalator of DNA, reacts slowly at PtII, the linker being displaced by nucleobases. Crystallization of 4,4′-vinylenedipyridine bis[2,2′ : 6′,2″-terpyridine platinum(II)] in the presence ...

Two 3D bimetallic coordination polymers, Mn(tvp)2[Ag(CN)2]2(I) and Cd(tvp)2[Ag(CN)2]2(II) (tvp = trans-4,4′-vinylenedipyridine), have been synthesized and characterized. The complexes I and II are isomorphic. They crystallize in monoclinic P2(1)/n space group. The coordination geometries of Mn2...

An efficient and single-step iodine catalyzed and metal-free synthesis of di and tri-substituted 2-methylfuran derivatives were achieved from 1-popargyl-1,2-diols. Stereospecific synthesis of starting 1,2-diols was achieved by indium mediated Barbier type propargylation on corresponding keto-alc...

Complexes of type ML2, ML2(H2O)2 and ML2(py)2 (LH = pyrazole-4,5-dione-4-oximes) have been prepared and their IR and LSIMS spectra, magnetic susceptibilities and behaviour towards triphenylphosphine and dimethyl acetylenedicarboxylate (DMAD) have been investigated. The structures of Zn(Mpo)2(H2O...

Reactions of 5-ethylamino-4-methyl-1,2,benzoquinone 2-oxime (5-Et-4-MeqoH) with lithium and sodium hydroxide produce a series of complexes of types [M(5-Et-4-Meqo)(5-Et-4-MeqoH)n] [n = 0, 1 when M = Na; n = 1, 2 when M = Li]. All the compounds in this series have been characterized by elemental ...

Theoretical and experimental approaches were applied for the investigation of the reactivity of persubstituted 4-nitrosophenols in the reaction with alkyl iodides, in particular the potassium salt of 2,6-di(alkoxycarbonyl)-3,5-dimethyl-4-nitrosophenol. Hartre–Fock calculations showed that the a...

RésuméPropargyltrimethylsilane reacts with carbonyl compounds to produce α-allenic alcohols in the presence of tetra-n-butylammonium fluoride.

RésuméPropargyltrimethylsilane reacts with carbonyi compounds to produce chloroprenic derivatives in the presence of titanium tetrachloride.

A very convenient method to prepare α-allenic amines from propargyltrimethyl-silanes and secondary amines via an aminomethylation-desilylation process is described.

Protodesilylation of varied propargyltrimethylsilanes, using boron trifluorideacetic acid as reagent, give regiospecifically terminal allenes with very good yields. Yet, particular ω-functional propargyltrimethylsilanes may lead to vinylsilanes resulting from a ring-closing cyclisation reaction.

Reactions of N-alkoxycarbonyliminium ions with propargyltrimethylsilane, promoted by Lewis acid, yield in most cases mixtures of allenes G and oxazinones H.

Intermolecular reactions of N-alkoxycarbonyliminium ions with propargyltrimethylsilane mainly lead to 6-(trimethylsilyl)methyl-3,4-dihydro-2H-1,3-oxazinones, formed by intramolecular trapping of a stabilized β-silyl vinylic cation. α-Allenyl carbamates are obtained as minor products. The oxazi...

The preparation of propargyltrimethylsilanes from trimethylsilylmethyl halides or triflate is reported.