(Chromon-3-yl)bis(indol-3-yl)methanes and E-2-hydroxy-3-(1-methylpyrrol-2-ylmethylene)chroman-4-ones have been obtained in good yields from 3-formylchromones on reaction with indoles and N-methylpyrrole under solvent-free conditions. Reactions of (chromon-3-yl)bis(indol-3-yl)methanes with guanid...

1.1. CGS 9343B is a novel, potent and selective inhibitor of calmodulin activity, which unlike other known calmodulin antagonists, does not inhibit protein kinase C activity and does not possess potential antidopaminergic activity. Here we show that CGS 9343B, like other calmodulin antagonists r...

We investigated the effects of the calmodulin inhibitor CGS 9343B on voltage-dependent K+ (Kv) channels using whole-cell patch clamp technique in freshly isolated rabbit coronary arterial smooth muscle cells. CGS 9343B inhibited Kv currents in a concentration-dependent manner, with a half-maxima...

The First examples of (Te, N, S) type ligands, 2-CH3SC6H4CHNCH2CH2TeC6H4-4-OCH3 (L1) and 2- CH3SC6H4CHNHCH2CH2TeC6H4-4-OCH3 (L2), and their metal complexes, [PdCl(L1)]PF6 · CHCl3 · 0.5H2O (4), [PtCl(L1)]PF6 (5), [PdCl(L2)]ClO4.CHCl3 (6), [PtCl(L2)]ClO4 (7), and [Ru(p-cymene)(L2)](PF6)2 · CHCl...

Peptides are the largest/most diverse class of molecules used by animals for chemical communication, and with their cognate receptors, are key players in modulating physiological/behavioral control systems, including those involved in adaptation to environmental change. Crustaceans have long ser...

ObjectiveAnti-Müllerian Hormone (AMH) is a quantitative marker for ovarian reserve found to be independent of the menstrual cycle. The objective of this study was to determine whether serum AMH levels correlate with sex maturity rating (SMR) in a group of peripubertal elementary school girls.

This article discusses the concept of combining steam methane reforming (SMR) with fluidized beds of oxygen carrier particles and presents results from process simulations in Aspen Plus of new process outlines with and without carbon capture. Conventionally, heat to steam reforming tubes is prov...

Core average power density of standard small modular reactors (SMR) are generally limited to 60–65 MW/m3, which is 40% lower than for a standard civil PWR in order to accommodate better thermal margins. While designing a SMR core for civil marine propulsion systems, it is required to increase i...

Operation with reduced number of operators is considered as an important operational mode to improve economics of a nuclear power plant (NPP) in the future and it will be more important for the small modular reactors (SMRs). To control NPPs efficiently and safely with a reduced number of operato...

Brain–computer interfaces (BCI) translate brain activity into control signals or commands for a device. Motor imagery of the limbs allows for modulating the sensorimotor rhythms (SMR), but there are up to 30% of the participants for whom electroencephalography (EEG) based SMR-BCI cannot detect ...

As the main stream of Hard Disk Drive (HDD) techniques, Shingled Magnetic Recording (SMR) drives have unique features different from conventional disk drives, e.g., append-only (sequential) write, indirect address mapping and garbage collection. Batch process is also designed to fully utilize th...

Despite evidence that Sensorimotor Rhythm (SMR) and beta1 neurofeedback have distinct cognitive enhancement effects, it remains unclear whether their amplitudes can be independently enhanced. Furthermore, demands for top-down attention control, postural restraint and maintenance of cognitive set...

ContextSensorimotor rhythms (SMR) have been the neuronal phenomena of choice in non-invasive EEG-based endogenous brain computer interfaces (BCIs) for more than two decades and SMR-based BCIs have achieved the highest degree of freedom control so far. Nevertheless, they are subject to long perio...

Following the Fukushima-Daiichi nuclear accident in March 2011, innovations are needed to improve the reliability of new generation nuclear power plants toward scenarios where electrical power and ultimate heat sink are lost. This paper describes an integral design and basic passive safety strat...

When the small modular reactor (SMR) operates off-grid, the load following demand increases. To solve this problem, a flexible load is used to compensate the electricity load. The flexible load comprises power-consuming systems that can change their load actively, such as district heating, desal...

Gracilistones A (1) and B (2), two new eudesmane-type sesquiterpenoids with an unusual tetrahydrofuran-fused 6/6/5 tricyclic ring system, were obtained from Acanthopanax gracilistylus under the guidance of LC-MS investigation. Their structures and absolute configurations were assigned by extensi...

Various GM3 derivatives which are present in A431 cells have different effects on the activity of the EGF receptor kinase. In order to systematically study these effects, the following GM3 derivatives have been synthesized: de-N-acetyl-GM3 (D1), de-N-acetyl-lyso-GM3 (D2), lyso-GM3 (D3), de-N-ace...

Various lysosphingolipids were prepared and their chemical structures were confirmed by thin layer chromatography, infrared spectroscopy, proton magnetic resonance spectroscopy and chemical analyses of sugars, aminosugars, fatty acids and long chain bases by gas-liquid chromatography. Some hemol...

6S RNA, a global regulator of transcription in bacteria, binds to housekeeping RNA polymerase (RNAP) holoenzymes to competitively inhibit transcription from DNA promoters. Bacillus subtilis encodes two 6S RNA homologs whose differential functions are as yet unclear. We constructed derivative str...

In this study, chondroitin sulfate/dermatan sulfate was isolated and purified from the skin of corb (Sciaena umbra) (CSG) with a yield of 6.2%. Chemical and structural analysis showed that CSG consisted of high sulfate content 28.74% and an average molecular weight of 15.46 KDa. The separation o...