The spiro form fluorescein hydrazide (1) bearing a cleavable active bond is characterized as a highly selective and sensitive fluorescence probe for Cu2+. In 0.01 M Tris–HCl buffer (pH 7.2), the probe displays a highly selective fluorescence-on response to Cu2+ only, instead of other common met...

Benzyl isothocyanate is the major active antibacterial metabolite in Salvadora persica roots “Siwak” beside two minor isothiocyanate derivatives namely; 3-methoxy benzyl isothiocyanate and 3-hydroxy benzyl isothiocyanate. The extraction condition effect on the amount of benzyl isothiocyanate w...

MET-TAMO and N-CPM-MET-TAMO were prepared by the same procedure used for the corresponding 5-desmethyl compounds, TAMO and N-CPM-TAMO, except that a new procedure was employed to synthesize the intermediate, 14β-amino-7,8-dihydromorphinone. Both MET-TAMO and N-CPM-MET-TAMO produced wash-resista...

Dihydromorphinone ketone reductases are new NADPH dependent drug metabolizing enzymes which occur predominantly in cytosol of liver and to a lesser extent in kidney and lung. The hepatic enzyme of the chicken has been found to differ from that of rabbit with respect to relative effectiveness of ...

The reaction of 2-(2-oxo-1,2-diphenylethoxy)- and 2-(1-methyl-3-oxobut-2-en-1-yloxy)benzo[d]-1,3,2-dioxaphospholes with hexafluoroacetone is a versatile approach to the synthesis of 6,6-bis(trifluoromethyl)-3,4-diphenyl-1,1-phenylenedioxy- 1-phospha-2,5,7-trioxabicyclo[2.2.1]heptane and 3,5-dime...

A selected ion flow tube study of the reactions of a series of gas-phase atomic cations (S+, Xe+, O+, Kr+, N+, Ar+ and Ne+) and molecular ions (SFn+ (n = 1–5), CFn+ (n = 1–3), CF2Cl+, H3O+, NO+, N2O+, CO2+, CO+, and N2+) spanning a large range of recombination energies (6.3–21.6 eV), with ace...

The artemisinin derivatives artelinic acid and artesunic acid are members of a class of compounds that have shown promise for the treatment of multidrug resistant strains of Plasmodium falciparum. Unfortunately, these compounds exhibit poor solubility and stability in aqueous solution. The resea...

A new one-pot procedure for the preparation of pentafluorophenyl and 3,4-dihydro-4-oxo-1,2,3-benzotriazine-3-yl esters of Nα-9-fluorenylmethyloxycarbonyl amino acids bearing no side chain protecting groups is described. The method gives the desired activated esters in high yield and purity with...

In a wide search program toward new and efficient antimicrobial agents, a series of substituted piperidin-4-one oxime ethers (5a–5k) was synthesized and tested for their in vitro antibacterial and antifungal activities. Also, the structures of these oxime ethers and their relative stereochemist...

A palladium-catalyzed oxidative acylation of 2-phenoxypyridines with benzylic and aliphatic alcohols via C–H bond activation is described. This protocol represents direct access to biologically active ortho-acylphenol derivatives, and provides new opportunities to use readily available alcohols...

Achiral–chiral column switching HPLC assay was developed to allow the separation and quantitation of the enantiomers of metoprolol in human urine by means of fluorescence detection. Urine samples were prepared by liquid–liquid extraction, followed by HPLC. The racemic metoprolol and internal s...

Pharmaceuticals are a large group of substances that have been recognized as environmental contaminants in recent years. Research on the pharmaceutical fate in soils is currently limited or missing. In this study, three pharmaceuticals (atenolol (ATE), carbamazepine (CAR), and metoprolol (MET)) ...

A selective, sensitive and high throughput liquid chromatography-tandem mass spectrometry (LC–ESI–MS/MS) method has been developed for separation and quantification of metoprolol enantiomers on a chiral Lux Amylose-2 (250 mm×4.6 mm, 5 μm) column. Solid phase extraction of (S)-(−)- and (R)-(+...

Metoprolol and its metabolites α-hydroxymetoprolol, O-desmethylmetoprolol, metoprolol acid and deaminated metoprolol were quantified in dog plasma using an isocratic high-performance liquid chromatographic method (with a BetaBasic Cyano column) with fluorescence detection. A solid phase extract...

During the last decade, β-blockers such as metoprolol (MTP) have been frequently detected in surface water, aquatic systems and municipal water at concentrations of ng/L to μg/L. Only a small number of studies exist on the toxic effects induced by this group of pharmaceuticals on aquatic organ...

The acyclic analogs of 2′,5′- and 3′,5′-oligoadenylates possessing all functional groups of the natural compounds were prepared on the basis of “oxydized-reduced” adenosine.

Spectrophotometric determinations of palladium(II) and tartaric acid were respectively investigated by using the color reactions between 2(5-nitro-2-pyridylazo)-5-(N-propyl-N-3-sulfopropylamino)phenol(5-NO2.PAPS) and palladium(II) in strong acidic media, and between 5-NO2.PAPS, niobium(V) tartar...

New 20 and 30 mm light path length twin flow-cells were designed for the simultaneous flow-injection spectrophotometric determination of trace amounts of copper and iron in patients sera. Hence, utilization of the twin flow-cell enabled the sensitive determinations. Copper and iron can be determ...

2-(5-Nitro-2-pyridylazo)-5-(N-propyl-N-sulfopropylamino)phenol (Nitro-PAPS) reacts with Pb(II), Cd(II) and Mn(II) in weakly alkaline media, yielding water soluble metal complexes having molar absorptivities of 7.6 × 104 (at λmax = 590 nm), 14.7 × 104 (λmax = 570 nm), and 10.7 × 104 (λmax =...

A highly sensitive flow-injection method is presented for the rapid and simple determination of iron in various salt samples. 2-(5-Nitro-2-pyridylazo)-5-(N-propyl-N-sulfopropylamino)phenol (Nitro-PAPS) was used as the chromogenic reagent for the spectrophotometric detection at 582 nm, yielding t...