This is a randomized trial (ATHENA study) in de novo kidney transplant patients to compare everolimus versus mycophenolic acid (MPA) with similar tacrolimus exposure in both groups, or everolimus with concomitant tacrolimus or cyclosporine (CsA), in an unselected population. In this 12-month, mu...

BackgroundThis study aimed to evaluate the relationships between concomitant biologic disease-modifying anti-rheumatic drugs (DMARDs) and prednisolone administration and blood tacrolimus exposure or serum CYP3A4/5-related markers in rheumatoid arthritis (RA) patients without severe disease activity.

BackgroundEffective immunosuppression through optimization of trough levels tacrolimus reduces post-transplant mortality rate in liver transplant cases.

In the present study, we investigated the inhibitory effect of tacrolimus, a macrolide immunosuppressive drug that acts through calcineurin inhibition, on voltage-gated K+ (Kv) channels expressed in native smooth muscle cells isolated from the coronary arteries of rabbits. Tacrolimus reduced the...

To evaluate the effectiveness and safety of tacrolimus in myasthenia gravis (MG) patients, a systematic review and meta-analysis was performed. Researches published between January 1, 2000 and December 31, 2017 in English language were searched in Medline, Embase, Cochrane Central Register of Co...

BackgroundLifelong adherence with post-transplant immunosuppression is challenging, with nonadherence associated with greater acute rejection (AR) risk.

Current sample processing (SP) methods for tacrolimus (FK506) immunoassays are mainly based on extraction of drug by organic solvent and divalent metal ions. Although these methods are effective for drug extraction and interference elimination, they suffer from drawbacks including inconvenience ...

IntroductionRenal transplantation is one of the best options for patients suffering from end stage renal disease (ESRD). Cyclosporine and Tacrolimus are mainly applied in immunosuppressive therapy after transplantation of liver, kidney, heart, and other organs. The used of immunosuppressant drug...

SummaryIntroductionAtopic keratoconjunctivitis is frequently associated with atopic eyelid dermatitis. It may require topical steroids, the prolonged use of which may cause ocular complications. Tacrolimus is an immunosuppressant used topically on the skin in atopic dermatitis. The purpose of th...

Evidence is presented strongly suggesting that O-seryl-N-acetylgalactosaminide glycohydrolase of Lumbricusterrestris is an α-glycosidase acting on N-acetyl-α-D-galactosaminides but not on the corresponding glucosaminides.

An assessment study involving the use of the transglutaminase (TGase) conjugation method and the nitride-technetium-99m labelling on a bis(thiosemicarbazone) (BTS) bifunctional chelating agent is presented. The previously described chelator diacetyl-2-(N4-methyl-3-thiosemicarbazone)-3-(N4-amino-...

The electrochemical reduction of pertechnetate ions (TcO4−) and properties of such formed reduced Tc containing species (ions and molecules) have been studied in strongly acidic media (4 ÷ 12 M aqueous H2SO4) using electrochemical (cyclic voltammetry (CV); chronoamperometry (CA), chronopotentio...

Iron nanoparticles are a promising new technology to treat contaminated groundwater, particularly as they can be engineered to optimise their transport properties. Technetium is a common contaminant at nuclear sites and can be reductively scavenged from groundwater by iron(II). Here we investiga...

Di-tert-butyldibenzo-18-crown-6 ether (CE) dissolved in a mixture of isodecyl alcohol and n-dodecane has been investigated for separation of technetium from alkaline low level waste (LLW). Technetium present as TcO4− pairs with sodium ion-crown ether complex formed due to high sodium nitrate con...

The electrochemical reduction of pertechnetate ions (TcO4−) have been studied in strongly alkaline media (0.3 ÷ 10 M aqueous NaOH) using electrochemical (cyclic voltammetry (CV); chronoamperometry (CA), chronopotentiometry (CP)) and spectroelectrochemical (UV-Vis OTTLE and Au-SERS) techniques. ...

A personal note in celebration of Professor Herrmann's 70th birthday, the author describes how the successful preparation of H3C99TcO3 and the still unsolved task of preparing [Cp*99TcO3] powered ultimately a plethora of organometallic 99Tc chemistry. Driven by the need for technetium carbo...

AimBreast cancer is a health problem worldwide with high incidence and mortality rates. It is well known that the development of more sensitive and specific diagnostic methods is of great importance since an early diagnosis is essential to successfully treat tumors. Lapachol is a natural compoun...

Groundwater at legacy nuclear facilities around the world is contaminated with radionuclides including strontium-90 and technetium-99, which are often present as co-contaminants. Here we investigated whether biostimulation of indigenous microbial communities by glycerol phosphate can co-treat 90...

The objective of this review is to evaluate materials for use as a barrier or other deployed technology to treat technetium-99 (Tc) in the subsurface. To achieve this, Tc interactions with different materials are considered within the context of remediation strategies. Several naturally occurrin...

Technetium (99Tc), a uranium-235 (235U) and plutonium-239 (239Pu) fission product, is a primary risk driver in low level radioactive liquid waste at U.S. Department of Energy sites. Previous studies have shown success in using Zero Valent Iron (ZVI) to chemically reduce and immobilize redox sens...