The solubilities of succinic acid, glutaric acid and adipic acid in propionic acid + water solvent mixtures at 304.25-354.65 K, and in propionic acid + ε-caprolactone + water solvent mixtures at 297.65-351.25 K were determined by the synthetic method at atmospheric pressure. The experimental da...

Metaphenylenediamine and acetylacetone react in presence of divalent nickel, cobalt and copper salts to form complexes of a 16-membered N4 tetradentate macrocycle, dibenzo-(f,n)-2, 4, 10, 12-tetramethyl-1, 5, 9, 13-tetrazacyclohexadeca-[16]-1, 3, 9, 11-tetraene. The complexes are characterised t...

We present the results of the investigation of delayed luminescence of 2,3-methoxy-8-azagona-1,3,5(10),13-tetraene-12,17-dione (8,9-dimethoxy-1,2,3,5,6,10b,11,12-octahydrocyclopentane[5,6]pyrido[2,1-a]isoquinoline-1,12dione) in solid solutions. Dual delayed luminescence with maxima in the region...

The Pd (PPh3) 4/Cu(I)I catalyzed cross coupling of (Z)-1-tri-n-butylstannyl-1,2,3,4,4-pentafluoro-1,3-butadiene with substituted aryl iodides provides a useful stereospecific route to (E)-1-aryl-1,2,3,4,4-pentafluoro-1,3-butadienes. Substituents, such as 4-nitro, 2-nitro, H, 3-CF3, 3-OCH3, 2-CH3...

A phytochemical investigation on the twigs and leaves of Flueggea virosa (Euphorbiaceae) led to the isolation of flueggenoids A – E (1–5), five new 13-methyl-ent-podocarpanes, together with eleven known compounds (6–16). Their structures and absolute configurations were elucidated on the basi...

A range of fluorohalopropanes has been synthesised for screening as potential inhalation anaesthetics. Of the 26 compounds tested 21 are novel, and a further 6 novel propanes are also described. Of the compounds screened, 14 gave good anaesthesia with minimal side effects in mice, and their biol...

The relationship between 19F chemical shifts in halogenated propanes and their structures are elucidated using MNDO calculations to determine the population of rotamers. The pairs of atoms gauche to a fluorine atom and van der Waals interaction between the two terminal substituents are responsib...

Water-borne polymeric dispersions of superhydrophobic monomers can be catalogued as high performance materials, particularly towards applications involving excellent water-barrier properties. Their industrial production however is challenging due to their low water solubility. This work illustra...

2-Phenylaminophenylacetic acid is a widely-exploited chemical scaffold whereby notable NSAIDs such as diclofenac and lumiracoxib were derived. Yet, their clinical usage has been associated with toxicities in the liver. While some studies have attributed toxicities to the bioactivation of both dr...

Inhibitors of the UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase (LpxC) represent a promising class of novel antibiotics, selectively combating Gram-negative bacteria. In order to elucidate the impact of the hydroxymethyl groups of diol (S,S)-4 on the inhibitory activity agains...

The four stereoisomers of 1-azabicyclo[2.2.2]oct-3-yl-α-hydroxy-α-(4-phenylboronic acid)-α-phenylacetale (QNB boronic acids, 1a-1d) were synthesized initially via 1-azabicyclo[2.2.2]oct-3-yl-α-hydroxy-α-(4-iodophenyl)-α-phenylacetate (iodo-QNBs, 6a-6d) using an adaptation of a published pr...

Ulcerative colitis is a disease that causes inflammation and ulcer in the lining of the large intestine. In this study we investigate the effect of Rhizophora apiculata (R. apiculata) on acetic acid induced colitis in mouse model. Experimental animals were randomized into four groups: normal unt...

SummaryObjectiveThe increasing importance of clinical isolates of Candida species and emerging resistance of Candida species to current synthetic antifungal agents have stimulated the search for safer and more effective alternative drugs from natural sources. This study was directed towards expl...

The 250 MHz proton spectra of the title compounds were recorded and analyzed in terms of chemical shifts and coupling constants. The spectral parameters suffice to uniquely determine the structure of the two compounds and provide valuable information about the conformations of their most stable ...

A unique differential reactivity between dihydroisoquinolines and 3-nitrocoumarins was observed and was exploited for the efficient construction of lamellarins and their isomeric benzofuran-8-oxoprotoberberine derivatives under acid-catalyzed or base-promoted conditions. Further, these prepared ...

Due to the potential for misuse of a wide range of anabolic steroids in horse racing, a screening test to detect multiple compounds, via a common class of metabolites, would be a valuable forensic tool. An enzyme-linked immunosorbent assay (ELISA) has been developed to detect 17α-alkyl anabolic...

The four possible isomers 16β-hydroxymethyl-5α-androstane-3β,17β-diol 1, 16α-hydroxymethyl-5α-androstane-3β,17β-diol 2, 16β-hydroxymethyl-5α-androstane-3β,17α-diol 3 and 16α-hydroxymethyl-5α-androstane-3β,17α-diol 4 with proven configuration were converted into the corresponding ...

Hydrosilylation of functionalized terminal arylalkynes with a variety of silanes catalyzed by PtCl2 or PtO2 in the presence of the air-stable and bulky Xphos ligand was investigated. Regardless of the electronic nature (electron withdrawing or donating group) and the position (o, m, p) of the su...

Reduction of 1,2-diaryl-substituted ethenes with Na metal in dry THF allowed easy access to a variety of 1,2-diaryl-1,2-disodiumethanes. These diorganometallic intermediates were elaborated into the corresponding 1,2-diarylethanes (aqueous work up), or cycloalkylated with 1,3-dichloropropanes. T...

The spatial magnetic properties (Through Space NMR Shieldings – TSNMRS) of two cyclobutadiene derivatives (2 and 5) and of a number of cyclobutadiene dianion derivatives (3, 4 and 6–8) have been calculated by the GIAO perturbation method employing the Nucleus-Independent Chemical Shift (NICS) ...