Electrophysiological studies, using chloral hydrate-anesthetized rats, were undertaken to determine whether hippocampal pyramidal neurons, receiving input from the medial septal nucleus, were affected by 5-hydroxytryptamine (5-HT) derived from the dorsal raphe nucleus. The pyramidal neurons in t...

Previous reports have shown that immobility time increases in the presence of suspended straws in association with an inhibition of straw-climbing behavior after acute administration of a prototypical anxiolytic benzodiazepine (BZD) such as diazepam. In this modified forced swim (MFS) test emplo...

In order to clarify the mechanism of action of the putative nonbenzodiazepine anxiolytic SM-3997 ((3aα, 4β, 7β, 7aα)-Hexahydro-2- (4-(4-(2-pyrimidiny1)1-piperazinyl)-butyl)-4, 7-methano-1H-isoindole-1, 3 (2H)-dione dihydrogen citrate), in vitro binding studies with radiolabeled compound were...

The effects of SM-3997 on central monoaminergic systens were evaluated by ex vivo measurement of monoamines and their metabolite levels in rat brain after intraperitoneal treatment of drugs and by in vitro measurement of monoamine uptake into rat brain slices. The effects of SM-3997 were also co...

The present study investigated whether there is any difference between the effects of benzodiazepine and non-benzodi-azepine anxiolytics on maternal aggression in lactating mice, using an ethological technique. We used SM-3997, a 5-HT1A receptor ligand, as a non-benzodiazepine anxiolytic. Behavi...

5-Demethylnobiletin is a hydroxylated polymethoxyflavone found in citrus plants that shows antiproliferative activities in several cancer cell lines. In this study, we investigated the effects and underlying molecular mechanisms of 5-demethylnobiletin on inhibition of cell growth, apoptosis, cel...

The trans- (3) and cis- (4) isomers of 1- (4-methoxyphenyl)-3-phenoxy-4-methylthio-4- methoxyimino-2-azetidinone have been synthesized. The structure of 3 has been investigated by X-ray diffraction. The compound crystallizes in a monoclinic system, space group P21/a, Z= 4, a=7.377(2), b=23.790(3...

The photorearrangement of benzyl phenyl ethers and methyl phenoxyacetates was investigated in methanol and in complexes with cyclodextrin in both the solid state and aqueous solutions. Irradiation in cyclodextrin media leads to a large change in product distribution with a very significant ortho...

AimPrevious clinical studies have demonstrated that tangganjian (TGJ), a modern Chinese prescribed medicine, has a clinical effect in the treatment of type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD). Our study aimed to investigate whether the phosphatidylinositol 3-...

Our present study investigated the anti-diabetic activity and potential mechanism of β-ecdysterone (β-EC) derived from Cyanotis arachnoidea. In vitro, β-EC exhibited a promising effect on increasing GLUT4 translocation by 1.6 folds and glucose uptake by 1.75 folds in L6 cells. In vivo, KK-Ay ...

The assessment of psychopathy in (forensic) schizophrenia spectrum disorders is long-standing debate. In the present study, we investigated the psychometric properties of the Comprehensive Assessment of Psychopathic Personality-Institutional Rating Scale (CAPP-IRS) in a sample of 72 male forensi...

SummaryOverexpression of insulin receptor substrate 1 (IRS-1) has been reported to promote cell growth, atypical hyperplasia, and carcinogenesis, and phosphorylated Akt (p-Akt) is certified to be involved in many types of cancers such as breast invasive ductal carcinoma (BIDC). However, the rela...

We investigate whether geographic proximity between corporate headquarters and IRS regional offices affects corporate tax avoidance and the likelihood and productivity of IRS examinations. Using geographic distance to represent information asymmetry, we find that corporations avoid more tax when...

AimsTo evaluate the therapeutic benefits of Hesperidin (Hes) using an imiquimod (IMQ)-induced psoriasis-like mouse model and human immortalized keratinocytes (HaCaT) cells stimulated with lipopolysaccharide (LPS).

Insulin/IGF-1 action is driven by a complex and highly integrated signalling network. Loss-of-function studies indicate that the major insulin/IGF-1 receptor substrate (IRS) proteins, IRS-1 and IRS-2, mediate different biological functions in vitro and in vivo, suggesting specific signalling pro...

Data in this report describes the effect of a single injection of bacterial lysate IRS-19 prior to irradiation of C57Bl/6 mice on recovery of colony-forming cells (CFC) after sublethal and lethal doses of radiation. The injection of IRS-19 promoted an earlier recovery of colony-forming cells in ...

A numerical simulation has been performed to study the natural convection cooling of an IRS device by varying Rayleigh number in the range of 1010 to 1012. Computations are carried out by varying the diameter ratio (DR) in the range of 1.02–1.3. Navier-Stokes equations and energy equation have ...

An experimental study was carried out on a laboratory-scale louvered conical infrared suppression (IRS) device to predict the air entrainment into it. A comparison has been made between the louvered conical, conical and the cylindrical IRS device based on the air entrainment ratio with increasin...

Human hemoglobin and its isolated β-subunits were denatured by addition of HCl so as to reach final pH values ranging from 2.0 to 3.2. The β-subunits were alkylated in both the β93 and β112 cysteines; this treatment makes the β-subunits monomeric. The kinetics of acid denaturation of the tw...

We have studied intracellular polymerization of hemoglobin S in suspensions of small populations of sickle cells using circular polarized light scattering. We argue that the preferential scattering of right circular polarized light (as expressed by measurements of the S14 Mueller scattering matr...