Ganoderic acid D (GAD) is a highly oxygenated tetracyclic triterpenoid. This study aims to assess the effects of GAD on the energy metabolism of colon cancer through the regulation of SIRT3 expression and whether this effect is related to acetylated cyclophilin D. The results demonstrated that G...

Protocatechuic acid (PCA) is a phenolic compound believed to have neuroprotective and procognitive activity. d-Galactose (D-Gal) is a sugar, which administered to mammals can induce cognitive deficits. The first aim of this study was to confirm the effectiveness of D-Gal administered orally in i...

Nanoporous Na+-montmorillonite perchloric acid (MPA) as a novel heterogeneous solid acid catalyst was easily prepared. The physico-chemical properties of the catalyst were analyzed by a variety of techniques including X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR)...

The hydration numbers of perchloric acid were calculated using the Raoult law. The initial simplificated model is based on the hypothesis of the free water mole fraction equality to the water activity. A cause-effect relation has been established between the violation of this law and the distort...

Although bicyclic acids have been reported to be the major naphthenic acids in oil sands process-affected water (OSPW) and a well-accepted screening assay indicated that some bicyclics were the most acutely toxic acids tested, none have yet been identified. Here we show by comprehensive multidim...

A four step synthesis of the title compounds 3 and 4 is reported. The HeIα-PE-spectra of both compounds reveal aconsiderable through-space interaction of the π-systems.

The synthesis of chiral tricyclo[4.3.0.03,8]nonane-4,5-dione was accomplished starting from enantiomerically pure (+)-(1S,5S)-bicyclo[3.3.1]nonane-2,6-dione 1. Ring contraction of the latter with thallium(III) nitrate proceeded with high stereoselectivity giving exclusively methyl (+)-(1S,4S)-(+...

The synthesis, antimycobacterial activity and 3D-QSAR study of two series of 4-(adamantan-1-yl) group containing quinolines conjugated to amino acids are described. The most potent analogs displayed in vitro antimycobacterial activity ranging between 1.00 and 3.125 μg/mL. To understand the rela...

From a root culture of Salvia austriaca, transformed with Agrobacterium rhizogenes, a new diterpenoid was isolated and its chemical structure was determined as 7-(2-oxohexyl)-11-hydroxy-6, 12-dioxo-7,9(11),13- abietatriene [= 7-(2-oxohexyl)-taxodione] on the basis of spectroscopic methods, espec...

Chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) are hematopoietic malignancies caused by the constitutive activation of BCR-ABL tyrosine kinase. Although direct BCR-ABL inhibitors, such as imatinib, were initially successful in the treatment of leukemia, many patients devel...

This paper addresses the development of a process to recovery uranium, thorium and rare earth elements from an industrial residue, with a subsequent removal of U and Th from the liquor generated. Sulfuric acid digestion followed by water leaching was found to be the best method to solubilise the...

Because of its unique properties thorium is considered as the main energy resource in the 3rd millennium. In Georgia are detected four Thorium ore occurrences: 1 - In the Sothern slope of the Greater Caucasus (Th con. 51 g/t - 3882 g/t), 2 - In the Dzirula massif (Th con. 117 g/t - 266 g/t), 3 -...

As a part of technological evaluation of Eskişehir-Beylikahir thorium ore of Turkey, a novel study on the separation of thorium from oxalate concentrate including Th, La, Ce, Pr, Nd, Sm, Eu, Gd were carried out. As a first step, thorium-rare earth elements (REEs) oxalate concentrate was precipit...

Determinations of the mobility of metals from tailings is a critical part of any assessment of the environmental impacts of mining activities. The leaching of thorium and uranium from the tailings of different processing stages of a niobium mine was investigated for several pH, ionic strengths a...

In this study, the atom substitutions that commonly affect the monazite lattice were considered as potential factors affecting the monazite electrophoretic mobility. The influence of light rare earth elements (LREE) substitutions and the presence of thorium, calcium, and silicate within the mona...

In the search for an efficient, fluorine-18 labeled amino acid based radiotracer for tumor imaging with positron emission tomography (PET), two new tryptophan analogs were synthesized and characterized in vitro and in vivo. Both are tryptophan alkyl-derivatives, namely 2-(3-[18F]fluoropropyl)-dl...

IntroductionIndoleamine 2,3-dioxygenase (IDO) catalyzes the initial step in the catabolism of l-tryptophan along the kynurenine pathway and exerts immunosuppressive properties in inflammatory and tumor tissues by blocking locally T-lymphocyte proliferation. Recently, 1-(2-[19F]fluoroethyl)-dl-tr...

In this study, ethyl acetate, acetone, ethanol and water extracts from flowers, stems and roots of Cistanche phelypaea (L.) Cout were appraised for radical scavenging activity (RSA) towards 1,1-diphenyl-2-picrylhydrazyl,2,2-azino-bis(3-ethylbenzo-thiazoline-6-sulfonic acid) and superoxide free r...

The total syntheses of three marine bis-indole alkaloids (1, 2, 4) of the topsentin family together with the synthesis of the unnatural deoxybromotopsentin (33) are described. Key elements include, a 1,2-addition-oxidation sequence to construct the bis-heteroarylketones (18, 19, 29, 30) and a Pd...

Topsentin, a bis(indolyl)imidazole marine natural product, inhibited the proliferation of cultured human and murine tumor cells at micromolar concentrations (ic50 values ranged from 4 to 40 μM) and was active against in vivo P388 leukemia (%TC = 137, 150 mg/kg, QD1-5) and B16 melanoma (%TC = 14...