The effect of adding amino acids on wine aroma is largely influenced by nutritional status of grape must. In this study, the effects of linoleic acid (LA) content on the aromatic function of branched-chain amino acids (BCAAs) addition were investigated in alcoholic fermentation of Cabernet Sauvi...

Single crystal of 2,6-Di-tert-butyl-4-(dimethylaminomethyl)phenol has been grown by the modified vertical Bridgman method. Single crystal X-ray diffraction studies of the crystal confirm that the material belongs to the monoclinic system and space group C2. Fourier Transform Infrared Spectroscop...

We have demonstrated that different enantioenriched 2-arylpropylsufonylbenzene derivatives are very useful building blocks for the synthesis of aromatic bisabolane sesquiterpenes. Their preparation and the exploitation of their chemical reactivity have been comprehensively investigated. Accordin...

An asymmetric synthesis of cis- and trans- 5-hydroxy-(D)-pipecolic acid, starting from glycinate Schiff bases is described. The approach involves the stereoselective alkylation to generate an unsaturated side chain which on cyclisation leads to the desired trans- or cis- 5-hydroxy-(D)-pipecolic ...

Starting from readily available methyl (2RS,5S) 5-(t-butyldimethylsilyloxy)-2-(2′-propenyl)-piperidine-carboxylate (1), a diastereoselective synthesis of homopipecolic acids 5a and 5b and of di-epistreptolutine derivative 10 is decribed.

A novel diastereoselective syntheses of both (2R,3R,5R)-1 and its enantiomer (2S,3S,5S)-1 were accomplished by employing trans-selective nucleophilic addition of cyanide to 3-benzoyloxy-N-acyliminium ions as the key step, starting from trans-4-hydroxy-L-proline.

A route to 2S,5S-and 2R,5S-hydroxypipecolic acid is presented, starting with the enantiopure 5S-5-hydroxy-piperidone 7. The key step of this reaction sequence is the chemoselective methylenation of the amide carbonyl group of 8 with dimethyltitanocene 9 to 10. The transformation of the exocyclic...

The potential of D-glucuronolactone for the synthesis of polyhydroxylated amino acids is illustrated by the enantiospecific syntheses of 2S,3R,4R,5S-trihydroxy-pipecolic acid, 2R, 3R, 4R, 5S-trihydroxypipecolic acid and 2R,3R,4R-dihydroxyproline.

K-259-2, a unique calmodulin antagonist, is an allyl chain containing anthraquinone natural product. A regiospecific synthetic approach towards K-259-2 is herein represented. The study also showcases a protocol for synthesizing heavily substituted bromo naphthoate which was found to be suitable ...

Yellow anthraquinone dichroic dyes, 1,5-bis(2-naphthylthio) anthraquinone 2 and 1-[4-(t-butyl)phenylthio]-5-(2-naphthylthio) anthraquinone 4 were synthesized. Dye 4 in addition to being highly soluble in fluorinated liquid crystals and having a very small temperature dependence of solubility, ha...

1,1-Dialkoxy-l,2-dihydrocyclobuta[b]quinolines were obtained in good yields starting from 2-methylquinoline, the key intermediate being 2,2-dichloro- 1′-formyl-1′,2′-dihydrospiro[cyclopropane-1,2′-quinoline] .

Isobaric vapor–liquid equilibrium (VLE) data for 1-butanol + methoxy(methoxymethoxy)methane (DMM2), and 1-butanol + 2,4,6,8-tetraoxanonane (DMM3) systems were measured at 101.3 kPa with a modified Rose still. The experimental binary system equilibrium data was correlated by Wilson, Non-Random T...

New singlet alkylthio(4-methylpent-3-en-1-ynyl)carbenes were generated by photolysis of corresponding 5-alkylthioethynyl-3,3-dimethyl-3H-pyrazoles and subsequently trapped by alkenes giving rise to 1-alkynyl-1-(alkylthio)cyclopropanes in yields up to 60%.

1-Bromo-2-chloro-3,3-dimethylcyclopropene reacts with methyl lithium in the presence of 2,3-dimethylbut-2-ene at above −70°C to give (4); 12C labelling shows that C-2 of the cyclopropane becomes the centre carbon of the allene.

The structure–activity relationships (SARs) of N-aryl-O-(2-phthalimidoethyl)thiocarbamates (C-TCs) and their imide ring-opened congeners (O-TCs) as non-nucleoside HIV-1 reverse transcriptase inhibitors were further investigated. The SAR strategy involved modifications of the N-phenyl ring follo...

A systematic investigation of the NiX2/Mebta (X = Cl, Br, NCS, NO3; Mebta = 1-methylbenzotriazole) reaction system in various solvents is described. Particular emphasis has been placed on determining the influence of the Mebta: Ni11 ratio on the identity of the reaction products. In the nitrate ...

A systematic investigation of the CuCl2/Mebta (Mebta = 1-methylbenzotriazole) reaction system is described, involving the determination of the influence of the CuII:Mebta ratio, the nature of solvent and the presence of counterions on the identity of the reaction products. As a consequence, comp...

The NMR parameters of 1-methyl- and 2-methylbenzotriazole have been obtained from their high resolution spectra. LAOCOON III was used to iteratively refine the reported chemical shifts and coupling constants. Hückel molecular orbital calculations were performed in the hope of facilitating the c...

A systematic investigation of the CuBr2/Mebta (Mebta=1-methylbenzotriazole) reaction system is described. Particular emphasis has been placed on determining the influence of the Mebta:CuII ratio and the nature of solvent on the identity of the reaction products. These combined variations have le...

A study has been made of the regioselectivities of some typical addition reactions of pbotoaldrin and epoxide ring-opening reactions of photodieldrin. The structures of the resulting products have been established by appropriate interconversions and syntheses. The factors responsible for the obs...