Validamycin A is widely used to control Basidiomycetes, which causes sheath blight disease in rice, potatoes, vegetables, and other crops as well as dumping-off disease in vegetable seedlings, cotton, sugar beets, and other plants. In order to improve the content of validamycin A in the commerci...

During the fermentation of Streptomyces hygroscopicus TL01 to produce validamycin A (18 g/L), a considerable amount of an intermediate validoxylamine A (4.0 g/L) is accumulated. Chemical or enzymatic hydrolysis of validamycin A was not observed during the fermentation process. Over-expression of...

A wide number of marketed drugs and drug candidates in cancer clinical development contain halogen substituents. The aim of the present study was to synthesize a series of halogen incorporated indole-coumarin hybrid schiff bases - N′-((2-(2-oxo-2H-chromen-3-yl)-1H-indol-3-yl)methylene)benzohydr...

A series of new steroidal pyridines have been synthesized through the based-promoted three-component reaction and preliminarily evaluated for their antiproliferative activity against different types of cancer cell lines. SARs studies showed that the heterocyclic rings attached to the 4-position ...

An efficient synthetic protocol affording symmetrical 1,2-bis(pyridine-2/3/4-yl)methyldiselanes from pyridine-2/3/4-carbaldehyde in high yields at room temperature, without using highly toxic hydrogen selenide, has been developed. The synthesis involves the reductive selenation of pyridine-2/3/4...

A mild, metal-free and efficient synthesis of 2,3-disubstituted acrylonitriles and α-iminonitriles through radical ring opening reaction of pyridine fused heterocycles has been developed. The tetra-n-butylammonium iodide catalyst acts as a formal one-electron donor. Compared to the previous met...

We report the study of a series of Ru-bipyridine (Ru-Bpy) complexes to correlate their photophysical and electrochemical properties to their performance in [4 + 2] cycloadditions, as a model reaction for electron transfer catalysis. Redox potentials, absorption and emission spectra, quantum yiel...

Hemoglobins A and S were crosslinked between Lys 82β1 and Lys 82β2 using bis(3,5-dibromosalicyl) fumarate (J. A. Walder et al. (1979) Biochemistry18, 4265). Thermal denaturation experiments were used to compare the stabilities of the met, cyanomet, and carbonmonoxy forms of these crosslinked h...

The thermodynamics and kinetics of the reaction DeoxyHb-Fe2+ ↔ MetHb-Fe3+ for human hemoglobin A (HbA), alpha- and beta-fumarate crosslinked hemoglobins were investigated by spectroelectrochemistry. Information from this study is used to determine what structural features and experimental condit...

The double-headed aspirin, bis(3,5-dibromosalicyl) fumarate, has been used to crosslink hemoglobin A between Lys 82β1 and Lys 82β2(J. A. Walder et al. (1979) Biochemistry18, 4265). Denaturation experiments were used to compare the stability of this crosslinked protein to that of hemoglobin A. ...

Bis(3,5-dibromosalicyl) fumarate was used to crosslink hemoglobin both in the oxy and deoxy states. This double headed diaspirin was known to crosslink oxy Hb A selectively between Lys82β1 and Lys82β2 (Walder, J. A., et al. (1979) Biochemistry 18, 4265) and deoxy Hb A between Lys99α1 and Lys9...

Shepherd's purse is a troublesome dicot weed that occurs in the major wheat-producing areas in China. Twenty-eight shepherd's purse populations were collected from winter wheat-planting areas in Henan Province and used to evaluate tribenuron-methyl resistance and acetohydroxyacid synth...

A co-metabolic degradation of tribenuron methyl bacterial strain NyZ42 was isolated from polluted agricultural soil and classified as genus Pseudomonas by its 16S rRNA gene sequencing. The degradation efficiency of tribenuron methyl was about 80% of the originally supplemented 200 mg l−1 tribenu...

The response of the imazamox resistant and susceptible sunflower hybrids Rimi and S to imazamox and of tribenuron-methyl resistant and susceptible hybrids Rsu and S to tribenuron-methyl was investigated both in a whole-plant bioassay and in field experiments. Plants were treated post-emergence w...

Flixweed seeds were collected from suspected winter wheat fields and remote hillside in Shaanxi Province, China, their sensitivities to tribenuron-methyl were evaluated in the greenhouse. Results revealed that biotype S was susceptible to tribenuron, and its GR50 was 0.23 g a.i. ha−1, whereas bi...

Rate-response experiments with nine putative resistant wild mustard (Sinapis arvensis) populations from Greece showed cross-resistance to tribenuron and imazamox. The calculated GR50 values [herbicide rate (g ai ha− 1) required for 50% reduction of fresh weight] of the nine resistant (R) populat...

Repeated application of pesticides disturbs microbial communities and cause dysfunctions on soil biological processes. Granstar® 75 DF is one of the most used sulfonylurea herbicides on cereal crops; it contains 75% of tribenuron-methyl. Assessing the changes on soil microbiota, particularly on ...

The acetolactate synthase (ALS) inhibitor tribenuron has been used continuously for approximately twenty years as an herbicide in winter wheat fields in China. Flixweed (Descurainia sophia) has evolved resistance to tribenuron, due to multiple amino acid mutations at the 197th residue of ALS. In...

The dissipation kinetics and residual levels of florasulam and tribenuron-methyl in wheat field ecosystem were determined using a quick, easy, cheap, efficient, rugged and safe method (QuEChERS) with rapid resolution liquid chromatography tandem mass spectrometry (RRLC-MS/MS). The average recove...

Myosoton aquaticum L., a widespread and competitive winter weed of wheat in China, has evolved resistance to many classes of herbicides. In one M. aquaticum population (AH03), collected from Anhui Province, where tribenuron-methyl and florasulam had been used to control this weed resistance to b...