The catalytic performance of the diphenyl-substituted pyridinyl alcoholato ruthenium carbene precatalyst of the Grubbs 2-type was optimized for 1-octene metathesis by varying operating parameters, such as reaction temperature (30–100 °C) and catalyst load (Ru/1-octene molar ratio between 1:500...

The [Pd(N–N∗)Cl2] complexes have been obtained, as yellow solids, in almost quantitative yields; N–N∗ indicate bidentate chiral ligands (Sa)-1, (Sa)-2, (S,S)-3, (R,R)-4, containing the rigid 2-pyridinyl or 8-quinolinyl building block skeleton and the C2-symmetric chiral framework trans-2,5-dim...

Some methyl- and phenyl-substituted 2,3-dihydro- and 2,3.4,5-tetrahydro-1H-1,5-benzodiazepines and 1,5-benzothiazepines are described: new examples are reported and some preparative routes revised. The compounds are characterized by their vibrational and electronic spectra and mass spectral frag...

The development of highly efficient and green catalyst for the one-pot synthesis of 5-substituted tetrazole and polyhydroquinoline derivatives is an extremely important and ground challenging area in organic chemistry. In this study, two catalysts were prepared by the immobilization of Ni and Cu...

A number of substituted indenols have been synthesized using ruthenium-mediated ring-closing metathesis (RCM) with Grubbs second generation catalyst as the key step. The required dienes were synthesized by two strategies. The first entailed the isomerization of 2-allyl-3-isopropoxy-4-methoxybenz...

In this work thermochemistry of solvation of mono-, di-, tri- and tetra-substituted benzenes in 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF4]) ionic liquid was studied. Enthalpies of solution at infinite dilution of 34 substituted benzenes in [BMIM][BF4] were measured at 298.15 K us...

We recently observed that 4-methylphenol (p-cresol) is toxic to rat liver tissue slices. A possible mechanism involves biotransformation of 4-methylphenol to a reactive quinone methide intermediate which covalently binds to cellular macromolecules and elicits cytotoxicity. In order to obtain fur...

The photocatalytic transformation of MCPA on TiO2 leads to 4-chloro-2-methylphenol (P3) as the major intermediate. Some minor intermediates were also identified, namely methylhydroquinone (P1), 5-chloro-2-hydroxy-3-methylphenylacetic acid (P2), 4-chloro-2-methylanisole (P5) and 4-chloro-2-methyl...

The synthesis and characterization of Cd(II), Zn(II), Pb(II), Co(III) and Ni(II) complexes of 5-methoxy-5,6-diphenyl-4,5-dihydro-2H-[1,2,4]triazine-3-thione LH2OCH3 are reported. The stoichiometry of the complexes was found to be 1:2 except for cobalt complex 4 where the ratio is 1:3. In all com...

Alzheimer's disease (AD) is a complex neurological disorder with diverse underlying pathological processes. Several lines of evidence suggest that BACE1 is a key enzyme in the pathogenesis of AD and its inhibition is of particular importance in AD treatment. Ten new 3-hydrazinyl-1,2,4-triaz...

Crude (4-methylcyclohexyl)methanol (MCHM) caused extensive contamination of drinking water, wastewater, and the environment during the 2014 West Virginia Chemical Spill. However, information related to the environmental degradation of cis- and trans-4-MCHM, the main components of the crude 4-MCH...

Acylation of potassium 2,6-di(alkoxycarbonyl)-3,5-dimethyl-4-nitrosophenolate with acetic anhydride and benzoyl chloride gave previously unknown 10 derived acyl compounds. 1H NMR spectroscopy and X-ray diffraction data have been used to show that the oxygen atom of the nitroso group undergoes ac...

BackgroundIntratracheal injection of basic fibroblast growth factor (b-FGF) has been shown to enlarge the tracheal lumen 4 weeks after treatment. The objective of this study was to investigate the long-term effect of tracheal cartilage growth promotion by intratracheal injection of b-FGF.

Wounds that heal with excessive scar formation result in poor functional and aesthetic outcomes. To address this, in our study, visible light cured glycol chitosan (GCH) hydrogels containing endothelial growth factor (EGF) and basic fibroblast growth factor (bFGF) were prepared (GCH-EGF, GCH-FGF...

Fibroblast growth factor 21 (FGF-21) is an important regulator in glycolipid metabolism that is a promising drug candidate for treatment of diabetes and obesity. However, the productivity of recombinant hFGF-21 (rhFGF-21) in Escherichia coli (E. coli) is relatively low, which limits its clinical...

Basic fibroblast growth factor (FGF-2) was effective to promote growth of hair. However, Because of its poor stability and low permeability against skin, the therapeutic effect of FGF-2 was hindered largely in clinical practice. To overcome these drawbacks, herein, FGF-2 was firstly encapsulated...

Implant bone defects are the most common phenomenon in the processes of bone transplantation. Evidences have identified that fibroblast growth factor-21 (FGF-21) encourages osteogenesis for patients with implant bone defects. The purpose of this study was to investigate the role of FGF-21 and it...

The FGF/ERK signaling pathway is highly conserved throughout evolution and plays fundamental roles during embryonic development and in adult organisms. While a plethora of expression data exists for ligands, receptors and pathway regulators, we know little about the spatial organization or dynam...

SummaryIntracellular transport of membranous organelles and protein complexes to various destinations is fundamental to signaling transduction and cellular function. The cytoplasmic dynein motor and its regulatory proteins LIS1 and NDE1 are required for transporting a variety of cellular cargos ...

AimMyokines are associated with regulation of bone and muscle mass. However, limited information is available regarding the impact of myokines on glucocorticoid (GC) mediated adverse effects on the musculoskeletal system. This study investigates the role of myokine fibroblast growth factor-2 (FG...