The solubility of citalopram hydrobromide in ethanol mixed with cosolvent toluene and ethyl acetate was measured at temperatures from 283.15 to 318.15 K to study the solubility improvement of the poorly soluble drug. The solubility increases with increasing cosolvent mass fraction w to a maximum...

Eletriptan Hydrobromide is a serotonin 5-HT1 receptor agonist and it used for the treatment of migraine headaches with or without aura. Even if the drug is well absorbed after oral administration, it has some drawbacks like first pass metabolism and decrease in bioavailability after migraine att...

A new, specific, precise and very sensitive spectrofluorimetric methodology has been established and approved for determination of Fenoterol hydrobromide (FEN) in its pharmaceutical forms and spiked plasma. The strategy utilized the phenolic nature of FEN and its capacity to undergo Von Pechman ...

The complete vibrational assignments for the alkaloid scopolamine as free base, quaternary scopolammonium cationic and hydrobromide species were reported for first time by using the internal coordinates, the scaled quantum mechanical force field (SQMFF) procedure and the experimental FT-IR, FT-R...

ω-(4-Bromophenyl)alkanoic acids 2c–e were obtained from 1-bromo-4-alkenylbenzenes 5c–e by hydroboration–thermal isomerization–oxidation. Their esters 11c–e were transformed in good yields into the corresponding boronates 12c–e by the cross-coupling reaction with 4,4,5,5,4′,4′,5′,5′-oc...

A methodology for the lithiation of pyrimidine (1a) was developed and used for the synthesis of pyrimidylselenium compounds. The procedure involved prior complexation of 1a with 2.2 equiv. of BF3·Et2O followed by a reaction with LDA or LTMP. The pyrazinylselenium derivatives were synthesized fr...

To explore the application potential of dual prodrug strategies in the development of anti-HCV agents, a variety of sofosbuvir derivatives with modifications at the C4 or N3 position of the uracil moiety were designed and synthesized. Some compounds exhibited potent anti-HCV activities, such as ...

Aldosterone-induced activation of mineralocorticoid receptor, a member of the nuclear receptor family, results in increased tissue damage such as vascular inflammation and cardiac and perivascular fibrosis. Benidipine, a long-lasting dihydropyridine calcium channel blocker, is used for hypertens...

AimsBenidipine, a dihydropyridine Ca2+ channel blocker, has been reported to block T-type Ca2+ channels; however, the mechanism underlying this effect was unclear. In this study, we characterized the mechanism responsible for this blocking activity. Furthermore, the blocking activity was compare...

SummaryFour hundred and 16 subjects (average age, 56.2 years; range, 20–92 years; Men/Women, 207/209) undergoing annual health check-up were studied for the effect of aging and hypertension on arterial compliance or elasticity index, which were measured after a 10 min rest in the supine positio...

We developed a method for determining benidipine, a dihydropyridine analogue calcium-channel blocker, in plasma using liquid chromatography–tandem mass spectrometry (LC–MS–MS). Benidipine and benidipine-d5, an internal standard, were extracted from plasma using diethyl ether in the presence o...

BackgroundGraft spasm remains challenging in coronary artery bypass grafting (CABG). Calcium antagonists are commonly used in patients with coronary artery disease. This study investigated the inhibitory effect of third-generation dihydropyridine calcium channel antagonist benidipine on the vaso...

In spite of remarkable advances in the knowledge on Trypanosoma cruzi biology, no medications to treat Chagas disease have been approved in the last 40 years and almost 8 million people remain infected. Since the public sector and non-profit organizations play a significant role in the research ...

IntroductionBenidipine has been reported to prevent the ischemia/reperfusion (I/R) damage in heart tissue and to suppress oxidant and proinflammatory cytokine production, increased by I/R. However, There was no information about the effects of benidipine on I/R injury in the ovary and the damage...

AimsBenidipine is a dihydropyridine (DHP) derived Ca2+ antagonist, can block triple Ca2+ channels (L, N, and T). It has been used as a safety anti-hypertensive drug because of its long-acting relaxant effect on vascular smooth muscle (VSM). However, whether benidipine has similar pharmacological...

Benidipine hydrochloride, used as an antihypertensive agent and long-acting calcium antagonist, is synthesized for commercial use as a drug substance in highly pure form. During the synthetic process development studies of benidipine, process related impurities were detected. These impurities we...

The activity of modified copper-cobalt-chromium oxide catalysts for the hydrogenation of CO2 to mixed alcohols(C2-Cθ) has been investigated. The results showed that copper-cobalt-chromium oxide was a most effective catalyst for hydrogenation of CO2, with a high CO2 conversion and an alcohol dis...

Publisher SummaryTransition metal carbonyls and their derivatives are remarkably effective and varied in their ability to catalyze reactions between unsaturated molecules. The carbonyl derivatives of cobalt are particularly active catalysts for such reactions and have been put to use in the indu...

A hierarchical micro-meso-macroporous Beta zeolite (HB) was developed by a steam-assisted crystallization method and was employed for cobalt Fischer-Tropsch synthesis. Meso-macroporous silica (HS), alumina modified meso-macroporous silica (HAS) and conventional Beta zeolite (CB) were used for co...

Operando DRIFT analysis of the surface species observed on Fischer Tropsch catalysts at work has been performed under H2/CO syngas at 503 K. Decomposition of the evolution in the IR operando spectra has been done by chemometric analysis in order to depict the modifications occurring on the surfa...