A series of coordination polymers, namely, [Zn(L)(HIP)(H2O)] (1), [Cd(L)(HIP)]·1/2H2O (2), [Co1.5(L)(BTC)(CH3OH)(H2O)3]·2H2O (3), [Ni1.5(L)(BTC)(H2O)4]·3H2O (4), where L = 2-(4-Chloro-phenoxy)-N-pyridin-3-ylacetamide, H2HIP = 5-hydroxyisophthalic acid, H3BTC = 1,3,5-benzenetricarboxylic acid,...

We synthesized and investigated (2-chloro-4-methoxy)-phenoxy pentafluorocyclotriphosphazene (2-Cl-4-MPPFPP) as a safety additive for lithium-ion batteries. Experimental results demonstrate that the addition of 2-Cl-4-MPPFPP into the base electrolyte reduces electrolyte flammability. Moreover, 2-...

The electrosynthesis of high quality large area self-supporting films of poly(3,4-dimethoxypyrrole) tosylate by galvanostatic oxidation of the monomer in propylene carbonate-tributylammonium tosylate on stainless steel anodes is described. The material is characterised by complete elemental anal...

Substitution of side groups is suggested as a method to modify and to improve the mechanical properties, mainly the brittleness, of polypyrrole. In this article poly (3,4-dimethoxypyrrole) (poly(DMOP)), a new substituted polypyrrole, is characterized from a physical point of view. The thermal, m...

We describe the use of 2-deoxy-D-[6-13C]glucose to follow simultaneously, by 13C NMR, both transport and phosporylation to its 6-phosphate form, in MCF-7 breast cancer cells in vitro and in vivo in subcutaneous tumors in nude mice.

Glutamyl cyclase (QC) is a promising therapeutic target because of its involvement in the pathogenesis of Alzheimer’s disease. In this study, we developed novel QC inhibitors that contain 3-aminoalkyloxy-4-methoxyphenyl and 4-aminoalkyloxyphenyl groups to replace the previously developed pharma...

A series of Arg-Phe-NH2 peptidomimetics containing an Arg mimetic were synthesized and tested as agonists of human MrgX1, rat MrgC, and mouse MrgC11 receptors. As predicted from the previously established species specificity, these peptidomimetics were found to be devoid of MrgX1 agonist activit...

The synthesis, in vitro evaluation, and conformational study of His-Phe-Arg-Trp-NH2 and related derivatives acting as antifungal agents are reported. Among them, His-Phe-Arg-Trp-NH2 and His-Tyr-Arg-Trp-NH2 exhibited antifungal activity against Cryptococcus neoformans. Antifungal activity of thes...

Chickpea peptides (ChPs) were found to significantly decrease serum total cholesterol (TC), total triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) content, and increase serum high-density lipoprotein cholesterol (HDL-C) content (P

A previously undescribed six residues long peptide His-Arg-Phe-Leu-Arg-His was identified and purified from the skin secretion of the amphibian Phyllomedusa centralis. A synthetic analogue carboxyamidated HRFLRH-NH2 showed structural changes induced by CO2 and metal ions in aqueous solution when...

A synthetic tetradecapeptide, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, which corresponds to the 13 amino terminal residues of human angiotensinogen plus a carboxy terminal serine to replace a suggested site of carbohydrate attachment, has been shown to be a good substrate fo...

The title compound was prepared in four steps and 62% yield from thymidine. After incorporation into synthetic oligodeoxynucleotides, the S-(2-cyanoethyl) group was removed by treatment with DBU in CH3CN to give products containing 4-thiothymidine residues.

Nitric oxide (NO) is an endogenous signaling molecule in plants. Sodium nitroprusside (SNP), an established NO donor used in plant science research, simultaneously releases NO, cyanide (CN−) and iron (Fe) in solution. Since cyanide and iron mask NO effect of SNP, its use in NO research is debata...

[5,5-2H2]-1-Deoxy-d-xylulose-5-phosphate was synthetically prepared.

Vibrio vulnificus, a gram-negative bacterium, is the leading cause of seafood-borne illnesses and mortality in the United States. Previous studies have identified metabolites 2-C-methylerythritol 4-phosphate (MEP) as being essential for V. vulnificus growth and function. It was shown that 1-deox...

Potentiometric equilibrium measurements were made at 5, 25, 35 and 45°C to determine the stability constants of Cu(II), Ni(II), Zn(II), Co(II), Mn(II), Mg(II) and Ca(II) with xanthosine in a 1:2 ratio (μ = 0.10 M KNO3). The enthalpy and entropy changes associated with the above interactions we...

The metabolism of [ethyl-14C] phenacetin in the rat and rabbit respiratory tract was studied. As shown by whole-body autoradiography, a selective binding of radioactivity occurred in the mucosa of the rat respiratory tract 5 min after an i.v. injection of [ethyl-14C] phenacetin. Microautoradiogr...

Pregnancy and puerperium raise the risk of thrombotic events, and these risks are likely to be increased in women who are carriers of thrombophilic gene polymorphisms. Prothrombin G20210A variant is reported to be the second most frequent prothrombotic polymorphism in Caucasians. Our aim was to ...

A novel prothrombin activator, Mikarin, has been isolated from Micropechis ikaheka venom. It is a single polypeptide chain metalloproteinase with the apparent molecular weight of 47 kDa. Mikarin exhibits Ca2+-independent prothrombin activation, but no effects on other blood coagulation factors, ...

The steady-state concentration of abnormal plasma prothrombin in warfarin-treated rats (10 mg/kg) was found to be approx. 6% of the plasma prothrombin level in normal rats. The clearance of abnormal plasma prothrombin in warfarin-treated rats was studied using either cycloheximide, to inhibit th...