In the complex PdL2 (HL = 4-butylphenyl 2-pyridyl ketone oxime), characterised by spectroscopic techniques and X-ray diffraction analysis, the deprotonated ligand displays a N,O coordination, with the pyridyl nitrogen and the oxime oxygen, which is without precedence in this class of compounds; ...

N-butyl-N,N-diphenylamine (BDPA) and N-4-butylphenyl-N,N-diphenylamine (BTPA) were polymerized by oxidation polymerization using iron (III) chloride as oxidant. BDPA showed higher polymerizability. Poly(BDPA) and poly(BTPA) showed UV absorption maximum at 362 and 373 nm. Oxidation potential of p...

Electrochemical copolymerization was utilized to combine several properties into a single material in order to obtain a highly stable polymer with a low band gap to meet the requirements for color variation. In that sense, two new donor acceptor type electrochromic copolymers of 2,3-bis(4-tert-b...

The preparation of a solubilised 2,2′ : 6′,2″-terpyridine ligand is described together with the characterisation of an unexpected intermediate. Homoleptic complexes of the solubilised ligand 4′-(4-tert-butylphenyl)-2,2′ : 6′,2″-terpyridine, 1, with cobalt(II), cobalt(III), ruthenium(II), ...

A series of anacardic acid analogues possessing different side chains viz. phenolic, branched, and alicyclic were synthesized and their antibacterial activity tested against methicillin-resistant Staphylococcus aureus (MRSA). The maximum activity against this bacterium occurred with the branched...

We have developed radiotracers based on agonists that may potentially allow the in vivo assessment of the high affinity (HA) state of the dopamine D-2 receptors. The population of HA state, which is likely the functional state of the receptor, may be altered in certain diseases. We carried out r...

In this paper we report the first chemoselective asymmetric hydrogenation of (1-bromo-1-alkenyl)boronic esters, which constitutes a new route to (α-bromoalkyl)boronic esters. The study demonstrates that excellent chemoselectivities along with full conversions can be obtained for hydrogenation o...

Inhibition constants for substituted phenyl and phenylethyl boronic acids have been determined. The trends and factors involved in their binding are discussed.

The pathogenic protozoa responsible for malaria lack enzymes for the de novo synthesis of purines and rely on purine salvage from the host. In Plasmodium falciparum (Pf), hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) converts hypoxanthine to inosine monophosphate and is essent...

(E)-9-(5-Phosphonopent-4-enyl)guanine and (E)-9-[3-(hydroxymethyl)-5-phosphonopent-4-enyl]guanine which bear a vinyl phosphonate moiety as a mimic of the phosphate group were synthesized. Their activities against human immunodeficiency virus type-1 (HIV-1), herpes simplex virus type-1 (HSV-1) an...

Guanine 11 was converted, in a one pot reaction, into 2-amino-6-[(4-chlorophenyl)sulfanyl]purine 9a in 88% isolated yield. 4-Acetoxy-3-(acetoxymethyl)butanol 23 was prepared from 2-chloroethanol in five steps and in 46% overall yield. The mesylate ester of compound 23 reacted with 9a in the pres...

A new, high radiochemical yield synthesis of [18F]FHBG and [18F]FHPG, the most popular imaging agents currently in use for monitoring gene therapy using positron emission tomography (PET), is reported in this work. Protection of sensitive sites in the precursors generally utilized for the prepar...

BackgroundHuman herpesvirus-6 (HHV-6) has been associated with a wide spectrum of diseases. (r)-9-[4-Hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) is an acyclic guanosine analogue that is structurally similar to acyclovir and is in clinical development for treatment of herpesvirus infections. H2G...

Antagonism of the gonadotropin releasing hormone (GnRH) receptor has shown positive clinical results in numerous reproductive tissue disorders such as endometriosis, prostate cancer and others. Traditional therapy has been limited to peptide agonists and antagonists. Recently, small molecule GnR...

Dihydroxy acidissiminol, a new tyramine derivative, was isolated from the methanol extract of defatted fruits of Limonia acidissima. The structure of the compound was determined as benzamide-N-{p-[(3,7-dimethyl-4,6,7-trihydroxy-2-octenyl)oxy] phenethyl} based on spectroscopic evidence. Two other...

The effects of Abana, an Ayurvedic remedy, administered orally to rabbits was studied for its effects on isolated atria and intestine. Administration of Abana for 3 days increased the basal amplitude and reduced the responses of atria to isoprenaline and norepinephrine. Combined treatment with A...

The induction of micronuclei was studied in mouse bone marrow treated or not with 5, 10 and 20 mg/kg b.wt. of abana (a herbal preparation) before exposure to 0–3 Gy of γ-radiation. Whole-body irradiation of mice resulted in a dose-dependent increase in the frequency of micronuclei. Treatment o...

The effect of various doses (0, 5, 10, 20, 40 and 80 mg/kg body weight) of 50% ethanolic extract of abana, a traditional herbal preparation, widely used in India for the treatment of heart ailments, was studied on the radiation-induced mortality in mice exposed to 10 Gy of γ-radiation. Treatmen...

The lignin from AFEX-pretreated corn stover and lignin model compounds were evaluated as the sole carbon source for microbial lipid production by Rhodococcus opacus NRRL B-3311. R. opacus NRRL B-3311 could grow on the AFEX-lignin without pretreatment and accumulate lipids up to 32 mg/L in 72 h w...

We report the synthesis of a single enantiomer of an α-methyl-trans-cyclopropane unit present in a number of mycolic acids and its incorporation into a reported 1,2-dialkylcyclopropane meromycolate that contains one cis-1,2-dialkylcyclopropane and one α-methyl-trans-1,2-dialkylcyclopropane.