Lipid oxidation has been implicated in the pathogenesis of many diseases. Lipids are oxidized in vivo by several different oxidants to give diverse products, in general lipid hydroperoxides as the major primary product. In the present study, the production of lipid hydroperoxides in the oxidatio...

Plasma hydroperoxides (HPs) are widely accepted to be good indicators of oxidative stress. By means of the method proposed here, which uses diphenyl-1-pyrenylphosphine (DPPP) as a fluorescent probe, all types of plasma HP were determined. The limits of detection and quantification of the method ...

By means of two alternative methods lipid and protein hydroperoxides (HP) were determined by fluorometry using the diphenyl-1-pyrenylphosphine (DPPP) probe. It has been shown that the formation of the fluorescence was influenced by the type of solvent and HP whereas the presence in the media of ...

A fluorometric method for the determination of hydroperoxides (HP) in edible oils and fats using the reagent diphenyl-1-pyrenylphosphine (DPPP) was developed and validated. Two solvent media containing 100% butanol or a mixture of chloroform/methanol (2:1, v/v) can be used to solubilise lipid sa...

Various alkylcarbonyloxymethyl esters of nalidixic acid ranging from 3 to 15 carbon units in the pro-moiety have been prepared and assessed as potential prodrugs. Their chromatographic retention factors k′, silicone oil solubilities and in vitro conversion to nalidixic acid by a commercial este...

Methyl tetradecanoate, deuterated in the penultimate position has been prepared by three synthetic routes. One method in which an oxoester is an intermediate, utilizes the selective reducing properties of sodium borodeuteride and sodium cyanoborodeuteride towards oxo, tosyloxy and ester groups t...

Herein, β-hydroxy methyl esters with an even carbon chain length of 12–20 1b–5b were synthesized by three different asymmetric reduction methods I, II III from their corresponding β-keto methyl esters 1a–5a with the aim of determining their elastase activities. In method I, chiral catalyst ...

BackgroundCyp147G1 is one of 47 cytochrome P450 encoding genes in Mycobacterium marinum M, a pathogenic bacterium with a high degree of sequence similarity to Mycobacterium tuberculosis and Mycobacterium ulcerans. Cyp147G1 is one of only two of these cyp genes which are closely associated with a...

Methyl 3-, 6- and 13-oxo tetradecanoates were reduced by NaBH4 in the presence of 1,2:5,6-di-O-isopropylidene-d-glucofuranose (DIPGH) and (−)-menthol together with isovaleric and pivalic acids in THF solution. The highest enantiomeric purity was found for the 13-hydroxy ester isomer of 96% ee. E...

Palm oil obtained from the mesocarp of Elaeis guineensis contains polyunsaturated fatty acids which are essential for normal human growth and development. Five samples of palm oil obtained from Cameroon (n = 3), Nigeria (n = 1) and Ghana (n = 1) and two palmist oil samples (commercially availabl...

The methoxymercuration-demercuration reactions of all the methyl cis-undecenoates are reported. Oxymercuration reaction of acetylenic esters gives keto- and hydroxy-esters when demercurated with hydrochloric acid and sodium borohydride respectively. Similar reactions are carried out with methyl ...

We developed an efficient, practical, and robust method for stereoselective preparations of (Z)-ketene trimethylsilyl (TMS) thioacetals from thioesters and alkyl (1Z)- or (1Z,3E)-1,3-bis(TMS)dienol ethers from alkyl β-ketoesters. The former preparation was performed by convenient procedure (LDA...

In this study, axially {4-[3-(9H-carbazol-9-yl)propoxy]phenyl}methoxy and ({3,5-bis[3-(9H-carbazol-9-yl)propoxy]phenyl}methoxy) substituted silicon phthalocyanines were synthesized by reaction of SiPcCl2 with {4-[3-(9H-carbazol-9-yl)propoxy]phenyl}methanol and {3,5-bis[3-(9H-carbazol-9-yl)propox...

In this paper, we report on theProd. Type: FTP fabrication and characterization of blue and white light emitting devices based on two fluorene-carbazole containing dendrimers and para-sexiphenyl (6P) oligomers. Blue light emitting diodes were fabricated using 9′,9″-(9,9-dioctyl-9H-fluorene-2,7...

The mutagenic activity of all 4 isomeric aminocarbazoles and 4 nitrocarbazoles was evaluated in Salmonella typhimurium tester strains TA98, TA100 and TA1535. All compounds were assayed both in the presence and absence of liver homogenate from Aroclor-treated rats. Among the aminocarbazoles, 2-am...

A selective copper(I)-catalyzed benzylic C(sp3)–H geminal difunctionalization reaction of a benzylic-type sp3 carbon was developed. This novel strategy allowed simultaneous introduction of amide and hydroxyl group in a highly selective and efficient way via successive oxidative intramolecular a...

Azelaic bishydroxamic acid (ABHA), a potent differentiating agent for lymphoid cells, was selectively toxic for 5 human tumor cell lines and transformed human melanocytes and keratinocytes (dose for 37% survival, D37, 30–100 μg/mL) compared with normal cells (melanocytes, fibroblasts; D37 > 30...

Continuous processing enables the use of non-standard reaction conditions such as high temperatures and pressures while in the liquid phase. This expands the chemist’s toolbox and can enable previously unthinkable chemistry to proceed with ease. For a series of amphoteric amino acid derivatives...

Water greatly restrained the formation of self-coupling of boronic acids in a palladium-catalyzed cross-coupling reaction between boronic acids and ethyl bromoacetate with an aminophosphine ligand; good to excellent yields of cross-coupling product were obtained.

New methodology is described for the enantioselective coupling of t-butyl bromoacetate with aldehydes to give anti-α-bromo β-hydroxy esters (1), useful precursors of chiral glycidic esters (2), acetate aldols (3), β-amino acid esters (4) and α-amino acid esters (5).