Magnesium pemoline, a central nervous system stimulant, is found to have a significant protective effect against ionizing radiations. Experimental results show that this drug is more potent than pemoline alone in exhibiting this radioprotective effect, and that dextroamphetamine does not possess...

PurposeTo develop a practical and reliable synthesis of 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (mannose triflate), a precursor of 2-deoxy-2-[18F]fluoro-D-glucose (FDG).

During the tapping of papaya latex for papain (EC 3.4.22.2), benzyl isothiocyanate is enzymatically produced from benzylglucosinolate, a major component of the latex fluid. Benzyl isothiocyanate inhibits papain hydrolysis of αN-benzoyl-l-arginine ethyl ester (Bz-Arg-OEt). Since the availability...

Bis(N-(2-phenylethyl)-N-substituted benzyldithiocarbamato-S,S′)nickel(II) (1–6) and (N-(2-phenylethyl)-N-substituted benzyldithiocarbamato-S,S′)(thiocyanato-N) (triphenylphosphine)nickel(II) (7–12) [substituted benzyl = 2HO–C6H4–CH2– (1,7), 3HO–C6H4–CH2– (2,8), 4HO–C6H4–CH2– (3,9), ...

A Convenient and simple synthesis of alkyl, aryl and amino acid isothiocyanates is described by the decomposition of ammonium dithiocarbamates using Claycop in mild conditions.

Two new organic–inorganic molecular solids of tetra(isothiocyanate)cobalt(II) dianion and meta-substituted benzyl triphenylphosphinium, [2ClBzTPP]2[Co(NCS)4] (1) and [4ClBzTPP]2[Co(NCS)4] (2) ([2ClBzTPP]+ = 1-(2′-chlorobenzyltriphenylphosphonium) and [4ClBzTPP]+ = 1-(4′-chlorobenzyltriphenylp...

Two new organic–inorganic molecular solids of tetra(isothiocyanate)cobalt(II) dianion and disubstituted benzyl triphenylphosphinium, [2Cl4FBzTPP]2[Co(NCS)4] (1) and [2Cl4ClBzTPP]2[Co(NCS)4] (2) ([2Cl4FBzTPP]+ = 1-(2′-chloro-4′-fluorobenzyltriphenylphosphonium) and [2Cl4ClBzTPP]+ = 1-(2′,4′-...

In the present study the feasibility of an in situ co-amorphisation of the basic drug carvedilol with the acidic co-former aspartic acid was investigated by immersion of film-coated tablets consisting of the two compounds in 0.1 M HCl. Tablets containing either crystalline carvedilol with aspart...

Dialkyl 2-(1-(alkylamino)-1,3-dioxo-3-phenylpropan-2-yl)malonates have been synthesized using a one-pot, pseudo five-component condensation reaction of isocyanide, Meldrum's acid, phenylglyoxal and two alcohol molecules in CH2Cl2 at ambient temperature. It was found that these structures co...

IR spectra of individual 4-n-dodecyloxybenzoic acid (A) and 4-pyridyl 4′-n-dodecyloxybenzoate (B) compounds as well as IR spectra of 2A:1B and 1A:1B systems were recorded. For the assignment of the experimental vibrational spectra a series of quantum chemical calculations of DFT(B97-D)/6-311++G...

The dermal oncogenic potential of β-(3,4-epoxycyclohexyl)ethyltrimethoxysilane (EEMS), γ-glycidoxypropyltrimethoxysilane (GPMS), β-(3,4-epoxycyclohexyl)ethyltriethoxysilane (EEES), and γ-glycidoxypropyltriethoxysilane (GPES) was assessed by applying 25-μl aliquots of acetone solutions to th...

The effect of methyltriethoxysilane, dimethyldiethoxysilane or phenyltriethoxysilane on the hydrolysis-condensation process of TEOS was investigated using hydrolysis time-condensation time curves. Viscosity measurements and 29Si-NMR investigations were also performed. It is found that the gelati...

A series of molecular building blocks containing allylsilyl groups, which can be incorporated into the appropriate sol–gel precursors as fragments, were prepared. The allylsilyl group is retained unchanged over the course of all reactions giving sol–gel precursors and behave as the synthetic e...

29Si nuclear magnetic resonance spectroscopy has been used to generate reaction profiles for the acid-catalysed hydrolysis and condensation of various substituted ethoxysilanes which may be used in sol-gel processes. Experiments were performed at acid concentrations that enabled hydrolysis rate ...

Effects of surface chemical modification with triethoxymethylsilane (TEMS) and ethoxy-trimethylsilane (ETMS) on the gas-sensing properties of SnO2 have been investigated, in comparison with the modification with diethoxydimethylsilane (DEMS) in our previous report. The largest amount of SiO2 was...

New reverse thermo-responsive polymers systems combining reverse thermal gelation behavior and a gradual increase in the mechanical properties, were created by crosslinking ethoxysilane-capped poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) triblocks in aqueous solutions at phy...

Liquid-state 29Si NMR was used to investigate the ammonia-catalyzed initial hydrolysis of different substituted ethoxysilanes dissolved in methanol. The following ethoxysilanes were used: tetraethoxysilane (TEOS), methyltriethoxysilane (MTES) and dimethyldiethoxysilane (DBS). Their reaction expr...

Divalent transition metal complexes ML2 (M = Mn 1; Co 2; Cu 3; Zn 4), possessing an ethoxysilane group as a part of the bidentate Schiff base ((E)-1-((3-(triethoxysilyl)propylimino)methyl)naphthalen-2-ol (L)), have been synthesized. While the copper complex 3 has been isolated in an analytically...

The structures and stereodynamic behavior of (O→Si)-chelate methyldifluorosilanes in solutions were studied by multinuclear (1H, 13C, 19F, 29Si) and 2D (COSY, HETCOR 1H, 13C) NMR spectroscopy. The range of studied complexes included amides RC(O)N(R')CH2SiMeF2 [R = Ph, R' = H (1a); R =...

The interaction of N-(2-hydroxyphenyl)acetamide with methyl(organyl)dichlorosilanes RMeSiCl2 (R = Me, Vinyl, Ph) leads to the formation of 5-membered silaheterocyclic benzoxazasiloles 1a-3a. According to data of NMR and FTIR spectra these compounds exist in equilibrium with 7-membered cyclic ben...