The syntheses, solid state and solution chemistry, and the in vitro cytotoxic activities of water soluble (1,2-diaryl-1,2-ethylenediamine)platinum(II) complexes, having either the sulfato or the novel sulfopropionato anionic leaving group, are described. The compounds were prepared by allowing t...

Meso-configurated [1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes (meso-4-PtX2) with SO42−, NO3−, PhSO3− cyclobutane-1,1-dicarboxylate (CBDC) and isocitrate as the leaving groups (X) and the two diastereomeric dichloroplatinum(II) derivatives were synthesized. The in...

Antitumor active [1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) diastereoisomers containing acetic acid derivatives as ‘leaving groups’ (acetate: meso/rac-4F-Pt(Ac)2; monochloroacetate: meso/rac-4F-Pt(ClAc)2; dichloroacetate: meso/rac-4F-Pt(Cl2Ac)2; trichloroacetate: meso/rac-4F-Pt(Cl3Ac...

The synthesis of the diastereomeric 1,2-bis(2-,3- and 4-fluorophenyl)ethylenediamines 4–6, 10–12 from meso-1,2-bis(2-hydroxyphenyl)ethylenediamine and 2-, 3- and 4-fluorobenzaldehyde by a diaza-Cope-rearrangement and their conversion into the [1,2-bis(2-, 3- and 4-fluorophenyl)ethylenediamine]...

The synthesis, the physiochemical and the breast cancer inhibiting properties of [meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chlorides (meso- and rac-4F-PtCl(DMSO)) are described. Rac-4F-PtCl(DMSO) surpasses the standard carboplatin in its eff...

The acylation of methylfuran has been investigated using Brønsted and Lewis acid zeolite catalysts. The highest reaction rate for acylation on a per gram basis is found on zeolite Beta with high aluminum content (Si/Al = 23) and the highest turnover frequency on a per metal site basis is found o...

The one-step reaction of salicylaldehydes with amines and alkenyl boronic acids or alkenyl trifluoroborates to form 2H-chromenes (2H-1-benzopyrans) has been investigated in more detail and new suitable conditions have been identified, including the use of tertiary amines and protic solvents incl...

A series of 3-nitro-2-phenyl-2H-1-benzopyrans (3a-h) were prepared and treated with diazomethane and diazoethane to give various benzopyranopyrazole derivatives namely [1,9-b]dihydro-3a- nitro-4-phenyl[1]benzopyrano[3,4-c]pyrazolines(4a-h), 4-phenyl[1]benzopyrano [3,4-c]pyrazoles (5a-h) and [1,9...

Pyruvate kinase M2 (PKM2) is a key protein responsible for cancer’s Warburg effect. Activation of PKM2 may alter aberrant metabolism in cancer cells, which suggests PKM2 as a tumor selective therapeutic target. In this paper, the lead compound 8 was first discovered as a new kind of PKM2 activa...

In this paper we present a pyridine synthesis, starting from N-protected amino acids. Amino acids are firstly converted to an ynone system, which is later converted to an enaminone system. Following a formal [2 + 2] cycloaddition of electron poor acetylenes and subsequent ring closure the final ...

Two selective stability-indicating HPLC methods are described for determination of rabeprazole sodium (RZ)–mosapride citrate (MR) and RZ–itopride hydrochloride (IO) mixtures in the presence of their ICH-stress formed degradation products. Separations were achieved on X-Bridge C18 column using ...

Nanotechnology-based bitherapy has recently emerged as an effective strategy to overcome biomedical barriers against successful anticancer therapy. The study aimed to evaluate lipid nanocarriers loaded with tamoxifen citrate/coenzyme Q10 (TC/CoQ10) as bitherapy for selective targeting of breast ...

Liquid–liquid equilibrium data have been determined experimentally for aqueous two-phase systems of brominated N-ethyl pyridine ([EPy]Br) and sodium dihydrogen phosphate (NaH2PO4) at T = 298.15, 308.15, 318.15, and 328.15 K, and data have also been obtained for aqueous two-phase systems compose...

Deli meat slicers have been implicated in cross-contamination of ready-to-eat (RTE) foods with Listeria monocytogenes that has resulted in several listeriosis outbreaks. We investigated the lethality of moist heat and silver dihydrogen citrate (SDC) sanitizer on Listeria species that were inocul...

Solutions of potassium dihydrogen citrate, KH2C6H5O7, exhibit reference pH values close to those of the primary standard pH buffer solutions of tartrate and phthate. Nevertheless, as opposed to all other recommended primary buffer standards, the citrate reagent is not commercially available as a...

Sildenafil citrate has short biological half-life in humans. Thus, matrix tablets of controlled release were designed and prepared by compaction on the basis of hydrophilic polymers, i.e. HPMC, sodium alginate, carbomer, poloxamer and their mixtures. The impact of these polymers on sildenafil re...

Magnesium oxysulfate (MOS) cement is a type of green inorganic cementitious material, with the advantages of light weight, low thermal conductivity, binding ability in light-weight panels, high temperature resistance and good fire resistance; however, its application range in practical engineeri...

Freezing temperature lowerings of aqueous solutions of tartaric acid, sodium hydrogen tartrate, sodium dihydrogen citrate, potassium dihydrogen citrate, disodium hydrogen citrate, sodium citrate and potassium citrate were determined. These values and those taken from the literature for potassium...

Nanocomposites of poly(butylene adipate-co-terephthalate) (PBAT) with montmorillonite (MMT) nanoparticles were prepared via melt blending. Natural MMT was modified by either octadecylamine (ODA) or dihexylamine (DHA). Neat PBAT was grafted with maleic anhydride via melt grafting process. Interca...

The synthesis, characterization, single crystal structures and physical properties of the compounds [Cu2(dpa)2(adp)2](H2O)2 (1) and [Ni2(dpa)2(adp)]Cl2 (2), in which dpa = 2,2′-dipyridylamine; adp = adipate(2−) anion, are presented. In both dinuclear compounds the dpa is chelating bidentately, ...