Five coordination compounds Zn(mbmpbi)2Cl2 (1), Zn(mbmpbi)2Br2 (2), Cd(mbmpbi)2Cl2 (3), Hg(mbmpbi)2Cl2 (4) and Hg(mbmpbi)2Br2 (5) were synthesized by the reaction of 1-(p-methoxybenzyl)-2-(p-methoxyphenyl)benzimidazole (mbmpbi) with the corresponding metal halides. The complexes have been charac...

Reconciling green synthesis, sustainability and production of pigments for protection of solar radiation is a continuous topic of search for unique, versatile and environmental compatible methods. In this perspective, we present the green synthesis of inorganic pigments with reflective propertie...

Profiling of oxylipins from young maize roots revealed complex patterns of products mainly originating from the combined actions of 9- and 13-lipoxygenases and allene oxide synthase (AOS). A distinctive feature was the high content of the cyclopentenone 10-oxo-11-phytoenoic acid (10-oxo-PEA). In...

Crude castor oil hydrolysates mainly consisting of ricinoleic acid can be biologically converted to 11-hexyloxy-9-undecenoic acid (C18) with an unsaturated bond and an ester bond which is utilized as a fertile chemical platform. The platform chemical of 11-hexyloxy-9-undecenoic acid can be conve...

Generally, year-to-year maintenance of the apical buds on spurs of Japanese pear ‘Kosui’ [Pyrus pyrifolia (Burm.f.) Nakai] is difficult; hence, flower buds become blind buds after blooming, whereas bud maintenance in another Japanese pear cultivar, ‘Shinsei’, is easy. Therefore, the effects ...

Elevated concentrations of nitric oxide (NO) and peroxynitrite (ONOO−) are present within the CNS following neurotrauma and are implicated in the pathogenesis of the accompanying neurologic deficits. We tested the hypothesis that elevated extracellular concentrations of ONOO−, introduced by the ...

Endothelial dysfunction is associated with the formation of peroxynitrite, described to be toxic. Recent data also suggests that peroxynitrite is able to activate the protective Nrf2 pathway and/or the unfolded protein response (UPR). The aim of our work was to study the response of human endoth...

In some neurological disorders, excessive nitric oxide (NO, nitrogen monoxide) produced by inducible and/or neuronal nitric oxide synthases (iNOS and nNOS) is able to combine with superoxide (O−2) to form peroxynitrite (ONOO−), which can then induce p53-dependent neural apoptosis. In the present...

In this study, a novel monomer molecule, N-(4-ethynylphenyl)maleimide (EPMI) with two polymerizable and modifiable groups (ethynyl and maleimido) was synthesized. Both radical and anionic polymerizations of EPMI at the vinylene group in a maleimide moiety yielded poly[N-(4-ethynylphenyl)maleimid...

One of the promising fields for improving the effectiveness of antimicrobial agents is their combination with efflux pump inhibitors (EPIs), which besides expanding the use of existing antibiotics. The goal of this research was to evaluate a series of aminoguanidine hydrazones (AGH's, 1–19...

Chemical and spectroscopic (UV; 1H, 13C, 15N NMR; HRMS) studies determined the structure of 1,1,4,10,10-pentaamino-2,3,5,6,8,9-hexaazadeca-1,3,5,7,9-pentaene for the red-violet compound, which was obtained by treating aminoguanidine hydrochloride with KOH. X-ray powder diffraction and lattice-co...

Thirty-six N-arylsulfonyl-3-substituted indoles were designed and synthesized by combining the N-arylsulfonylindoles with aminoguanidine, semicarbazide, and thiosemicarbazide, respectively. Their antibacterial activities were screened, and cytotoxic activities were evaluated. The results showed ...

Giardia duodenalis is an ubiquitous parasitic pathogen that causes significant morbidity and mortality worldwide. Failures in drug therapy are commonly due to poor patient compliance as a result of the need for repeated administration, off target drug effects and increasing parasite drug resista...

Nitric oxide (NO) triggers escape reactions in the dorsal periaqueductal gray matter (dPAG), a core structure mediating panic-associated response, and decreases the release of BDNF in vitro. BDNF mediates the panicolytic effect induced by antidepressant drugs and produces these effects per se wh...

BackgroundIndole-3-guanylhydrazone hydrochloride (LQM01) is a new derivative of aminoguanidine hydrochloride, an aromatic aminoguanidine.

Interaction studies with inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) inhibitor have been conducted to assess the nature of interaction and the possible therapeutic advantage. The interaction between meloxicam – a selective COX-2 inhibitor – and aminoguanidine hydrochlor...

A gas-phase study of 3-chloro-1-propene by electron diffraction showed that the most abundant conformer was gauche with a torsional angle τ=120.8(5.4)°, relative to τ = 0 for syn from when all heavy atoms are in the same plane and the chlorine atom is eclipsing the double bond. At 20 and 90°...

The molecular structure of 3-chloro-2-chloromethyl-1-propene has been studied by electron diffraction in the gas phase at a nozzle temperature of 90°C. The experimental data are consistent with a model of a mixture of two conformers, GG (66%, σ = 6.7%) and AG (34%); however, the presence of a ...

2-Chloro-3-fluoro-1-propene has been studied by electron diffraction, and the molecule was found to exist in equilibrium between a syn and a gauche conformation, with the syn conformation as the most stable. The most important structure parameters with standard deviation are: rg(CC) = 1.338(6)...

High quality poly (5-cyanoindole) (P5CI) films were synthesized electrochemically by direct anodic oxidation of 5-cyanoindole on a stainless steel sheet in boron trifluoride diethyl etherate (BFEE) + 50% diethyl ether (EE) (v/v) + 0.05 mol L−1 Bu4NBF4. They can be peeled off the electrode into f...