While investigating the reaction of 1-butanol over base catalysts, such as MgO, we observed the formation of small amounts of 4-heptanone. Further studies revealed that a CeO2/MgO catalyst gave good selectivity to this product. To optimise the reaction and determine the reaction mechanism a seri...
Streptomyces cinnamonensis produces butyraldehyde, isobutyraldehyde and valeraldehyde in concentrations of 9–39 μg ml−1, with the average molar ratio being 22:33:45. These aldehydes, excreted into fermentation broth or agar, were derivatised with 2,4-dinitrophenylhydrazine, isolated, and their...
This paper reports the density, refraction index, and (vapor + liquid) equilibria (VLE) for binary systems {aldehyde + 1-ethyl-3-methylimidazolium ethylsulfate ([emim][EtSO4])}: {propionaldehyde + [emim][EtSO4]} and {valeraldehyde + [emim][EtSO4]}. The uncertainties for the temperature, pressure...
Rotational spectra of p-anisaldehyde were obtained at a very low temperature in a pulsed beam Fourier transform-microwave spectrometer and over a range of much higher temperatures in a continuous wave spectrometer. Two species with ground state rotational constants A = 4661.95(4) MHz, B=698.3951...
The molecular structure of p-anisaldehyde has been determined by electron diffraction. The experimental data are consistent with a planar model with a fairly low barrier torsional motion about the phenyl-methoxy linkage. This barrier is estimated to be between 3.5 and 12 kJ mol−1. Appreciable an...
The density, ultrasonic velocity, and viscosity of binary mixtures of (anisaldehyde + o-cresol, or +m-cresol, or +p-cresol) have been measured over the entire range of composition at T = (303.15, 308.15, 313.15, and 318.15) K. Using these data, various thermo-acoustic parameters such as deviatio...
The white-rot basidiomycete Pleurotus ostreatus produced sweet flavor compounds on a liquid medium. The major and minor compounds identified by GC-MS analysis were p-anisaldehyde (4-methoxybenzaldehyde) and 3-chloro-p-anisaldehyde (3-chloro-4-methoxybenzaldehyde), respectively. p-Anisaldehyde wa...
The FTIR and FT Raman spectra of p-anisaldehyde has been recorded in the regions 4000–400 and 3500–100 cm−1, respectively. The optimized geometry, frequency and intensity of the vibrational bands of p-anisaldehyde were obtained by ab initio and DFT levels of theory with complete relaxation in ...
Nisin is used as a food-safe antimicrobial agent and has been widely applied to daily food products to prevent bacterial growth. However, the practical application of nisin is limited. Although nisin inhibits the growth of Listeria monocytogenes, exposure to this agent is also a risk factor for ...
Staphylococcus aureus (S. aureus) infections resistant to a variety of drugs have been increasingly documented in recent years. Drug resistance has appeared largely due to extensive use of antibiotics. Nisin has been widely used in food industry to prevent bacterial growth. However, nisin resist...
Inhibitors of topoisomerase I constitute a novel family of antitumor agents. The class of benzimidazole derivatives contains compounds possessing affinity to DNA. For example, fluorescent stains Hoechst 33342 and Hoechst 33258 interact with DNA as ligand and produce nonspecific inhibition of the...
The optimization of a series of benzimidazole glucokinase activators is described. We identified a novel and potent achiral benzimidazole derivative as an allosteric GK activator. This activator was designed and synthesized via removal of the chiral center of the lead compound, 6-(N-acylpyrrolid...
A series of 2-(trifluoromethyl)-1H-benzimidazole derivatives with various 5- and 6-position bioisosteric substituents (–Cl, –F, –CF3, –CN), namely 1–7, were prepared using a short synthetic route. Each analogue was tested in vitro against the protozoa Giardia intestinalis and Trichomonas va...
A series of 28 novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidine derivatives were synthesized and evaluated for in vitro antibacterial activities against Staphylococcus aureus and methicillin resistant S. aureus (MRSA) by the tube dilution method. The results showed that compo...
A series of forty different pyrazole containing benzimidazole hybrids (6–45) have been designed, synthesized and evaluated for their potential anti-proliferative activity against three human tumor cell lines - lung (A549), breast (MCF-7), and cervical (HeLa). Some of the compounds, specifically...
The preparation and proof of absolute configuration as 1d- and 1l- respectively are presented for (−)- and (+)-1,2:4,5-di-O-cyclohexylidene-3-O-allyl-myo-inositol, two versatile complementary materials equally suitable for syntheses in the 1d-myo-inositol series.
Optically active 2,3,6-tri-O-benzyl-4,5-di-O-(trans-prop-1-enyl)-D-myo-inositol and 1,2-di-O-palmitoyl-sn-glycerol were coupled using mono- and bifunctional phosphitylating reagents to yield, after final removal of all benzyl-protecting groups the chiral title compound.
1,3,4,5,6,7,8-Heptafluoro-2-naphthyl prop-2-enyl ether (8) was isomerised in boiling xylene to 1,3,4,5,6,7,8-heptafluoro- 1-(prop-2-enyl)naphthalen-2-one (9). Photolysis of (9) gave 2,5,7-trifluoro-3,4-(tetrafluorobenzo)tricyclo[3.3.1.O2,7]non-3- en-6-one (11) (by a [2 + 2] addition) and 1,2,7-t...
A successful generation and utilization of prop-2-ynyl/enyl-sulfanyl ketene in the synthesis of previously unknown pyrimidinones and their thio-Claisen rearrangements leading to thienopyrimidinones is described.
Pd(II)Cl2 (1 mole equivalent)/CuCl/DMF-H2O/O2/2h catalysed oxidation of various prop-2-enyl ethers 1a–12a is reported to result in the formation of Wacker ketones 1b,3b,5b,6b,9b,11b,12b (12–51%), hydrolysis products 2c,4c–7c,9c–12c (12–43%) and η2-vinyl complexes of palladium chloride 2d,4...
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