Peroxidation of the phenazine of β-lapachone using m-ClC6H4CO3H/CH2Cl2 furnished a macrolactone with a rigid 10-membered ring, and the corresponding N-oxide, originating from the oxidative cleavage of the aromatic double bond at the site of fusion of the dihydropyrane moiety with the phenazine ...
In this work, the synthesis and characterization of fac-[Re(CO)3(Nqphen)(L)]PF6 complexes is reported. Nqphen is the quinone substituted acceptor ligand [3,2-a:2′,3′-c]-benzo[3,4]-phenazine-11,16-quinone, and L represents the donor monodentate pyridine substituted ligands 4-tert-butylpyridine ...
An operationally simple and efficient one-pot method for the synthesis of 1-aroyl (or alkanoyl)-2-thioalkyl-3-aryl (or alkyl)-3H-benzo[e]indole-4,5-diones and naphtho[2,1-b]thiophene-4,5-diones has been devised by copper-catalyzed cross-coupling of α-oxoketene N,S-acetals/β-ketothioamides with...
We report here an alternative to the MCPBA or ozonolysis-based oxidation methods of quinoxaline-featuring compounds prepared from beta-lapachones. The use of peracetic acid allowed a simple preparation of the corresponding macrolactones by cleavage of the ring system. These lactones were evaluat...
An efficient one-pot quantitative procedure for the preparation of functionalized benzo[a]pyrano[2,3-c]phenazine derivatives from four-component reaction of 2-hydroxynaphthalene-1,4-dione, o-phenylenediamine, aldehydes, and malononitrile in the presence of nano CuO as the catalyst has been devel...
Phenazine 5,10-dioxides are prodrugs for antitumor therapy that undergo hypoxic-selective bioreduction to form cytotoxic species. Here we investigate the expanded system benzo[a]phenazine 7,12-dioxides as selective hypoxic cytotoxin-scaffold. The clonogenic survival of V79 cells on aerobic and a...
The photochemical behavior of benzo[a]pyrido[2′,1′:2,3]imidazo[4,5-c]phenazine dyes was studied in the presence of diphenyliodonium and triarylsulfonium salts that are used in photoredox systems for light-induced cationic polymerization. The fluorescence quenching of these dyes were examined i...
We present an investigation on the site specific interaction of antitumor agent benzo [a] phenazine (BAP) with serum albumins (HSA and BSA) and related photo-physical properties using absorption, emission and lifetime measurements. The absorption and emission measurements reveal that the binding...
An efficient, novel, and concise one pot regio- and chemoselective synthesis of benzo[a]phenazines (4) and naphtho[2,3-d]imidazoles (8) has been accomplished in excellent yields by nucleophilic substitution reaction of 2,3-dichloro-1,4-naphthoquinone (1) with o-phenylenediamine (2) and benzamidi...
New photochromic title compounds 1, 2, and 3 have been prepared starting from 4-methylphthalic anhydride. Compounds 3a and 3b are a pair of enantiomers and were obtained as a racemic mixture (numbered as 3). Compounds 1, 2, and 3 were successfully separated from the isomeric mixture product thro...
Transamidinase of kidney and pancreas was shown to catalyze the formation of γ-guanidinobutyric acid from γ-aminobutyric acid and arginine. The enzyme was also shown to be present in brain. Glycine was about ten times more active than γ-aminobutyric acid. A number of amino acids were tested f...
Publisher SummaryThis chapter discusses different types of amino acids. Monoaminomonocarboxylic acids require no special preparative methods. Peptides containing glycine, alanine, valine, leucine, isoleucine, or phenylalanine and peptides composed of only one of these amino acids have been frequ...
The six-loop expansions of the renormalization-group functions of φ4 n-vector model with cubic anisotropy are calculated within the minimal subtraction (MS) scheme in 4−ε dimensions. The ε expansions for the cubic fixed point coordinates, critical exponents corresponding to the cubic universa...
Martensitic transformation induced by strain in duplex stainless steels is a good option to increase their strength and elongation. The influence of low deformation levels on the phase transformation was studied in a 2304 lean duplex stainless steel. It was demonstrated that this steel exhibited...
A synthetic approach to the dicyano-substituted ε-caprolactone was developed. It consists of a cyclohexanone ring assembly through the Diels-Alder reaction followed by the Baeyer-Villiger oxidation. Ring-opening polymerization of the synthesized monomer, catalyzed by the aluminum alkoxides, was...
Low carbon steels containing 15–19 wt% Mn were processed to study the influence of Mn content on the thermally induced and deformation-induced ε-/α′-martensitic transformation and tensile properties of high-Mn TRIP steels. The stability of austenite and ε-martensite was studied in terms of ...
SummaryDiet-induced obesity can be caused by impaired thermogenesis of beige adipocytes, the brown-like adipocytes in white adipose tissue (WAT). Promoting brown-like features in WAT has been an attractive therapeutic approach for obesity. However, the mechanism underlying beige adipocyte format...
c-oriented Cu doped ε-Fe2–3N films are fabricated on c-Al2O3 by magnetron sputtering. It is found that the crystal constant c decreases with increasing Cu doping amount, which is due to the smaller radius of Cu atoms. The XPS peaks of Fe 2p and Cu 2p are confirmed with Fe-N and Cu-N binding en...
Let (X,A,μ) be a probability space and let S:X→X be a measurable transformation. Motivated by K. Nikodem's paper from 1991 published in the Czechoslovak Mathematical Journal [7], we concentrate on a functional equation generating measures that are absolutely continuous with respect to μ ...
This study reports the metal-free synthesis, the characterization and the micellization of a novel type of amphiphilic biocompatible and thermo-sensitive graft copolymers. It comprises a hydrolytically degradable hydrophobic poly(ε-caprolactone) (PCL) backbone and water-soluble thermo-sensitive...
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