The Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase (α3:β3:γ:δ:ε:a:b:b’:c9) is an essential enzyme that supplies energy for both the aerobic growing and the hypoxic dormant stage of the mycobacterial life cycle. Employing the heterologous F-ATP synthase model system αchi3:β3:γ we sho...
Let f,g:X→Y be a pair of maps of a compact, connected, oriented Riemannian manifolds, with or without boundary of the same dimension. In this paper we introduce the concept of the epsilon Nielsen coincidence number Nε(f,g) and develop an algebraic method for computing the epsilon Nielsen numbe...
The synthesis of three types of pulvinic acid analogues, using a diversity-oriented strategy starting from a single compound, dimethyl l-tartrate, is described. Lacey–Dieckmann condensation, alcohol dehydration and Suzuki–Miyaura cross-couplings were employed in the course of the analogues syn...
The synthesis of phosphonates of methylenecyclopropane nucleoside analogues 15a–18a, 15b–18b and 15c–18c by alkylation–elimination approach is described. In a foreshortened series, methanesulfonate 19 was transformed by Michaelis–Becker reaction with diethyl or diisopropyl phosphite to meth...
The high-temperature (=400°C) decomposition of methylenecyclopropane and its methyl derivatives proceeds, in part, with formation of an olefin and acetylene. The latter probably arises via a vinylidene intermediate. From the measure of activation energy a value of ΔHf0(CH2C:) ⩽ 409 ± 10 kJ ...
γ-Irradiation of 2,2-diphenyl-1-methylenecyclopropane (3) in a degassed 2-methyltetrahydrofuran glassy matrix at 77 K gave an intense UV/vis absorption band with λab at 496 nm. This result and calculations based on density functional theory for its radical anion 3− and the corresponding trimet...
The interaction of phosphine nickel complexes Ni(PPh3)3 and Ni(PPh3)2(η2-C2H4) with methyl derivatives of methylenecyclopropane and cyclopropene has been studied. The novel olefin complexes: (η2-2,2-dimethyl-1-methylenecyclopropane)bis(triphenylphosphine)nickel, (η2-1,3,3-trimethylcyclopropen...
2-Phenyl-1-methylenecyclopropane is isomerized into 2-phenyl-1,3-butadiene and 1-phenyl-1,3-butadiene in the presence of catalytic amounts of RhH(CO)(PPh3)3 and RhH(PPh3)4. The Rh-containing product of the reactions has a 2-phenyl-1-methylallyl (or 1-phenyl-1-methylallyl) ligand, and is formed a...
PtI2(PPh3)2-catalyzed hydrosilylation of 2,2-diphenyl-1-methylenecyclopropane with HSiEt3 forms (2,2-diphenylcyclopropyl)methyl(triethyl)silane in 87% yield as a sole product. This highly selective addition of SiH bond converts 2,2-diaryl-1-methylenecyclopropane into its silylated derivative w...
The reactions of unactivated bis(methylene)cyclopropanes with nitrones and nitrile oxides have been investigated. The 1,1-diaryl-2-isopropylidene-3-methylenecyclopropanes react with the C,N-diarylnitrones to give a mixture of 2,2-dimethyl-1,6-diaryl-3-(diarylmethylene)piperidin-4-ones and 5-meth...
In the present study, a new series of biheterocycles pyrazoline-thiazolidinones derivatized at fifth position with substituted arylidene groups were developed as potent inhibitors of Escherichia coli FabH (PDB: 5BNS) an antimicrobial target. These compounds are conveniently synthesized from 3,5-...
A series of thymol based substituted pyrazolines and chalcones was synthesized and evaluated for antimalarial activity, using in-vitro and in-vivo malaria models. All the target compounds (5a-k and 6a-j) were found to be active against human malaria parasite strain Plasmodium falciparum NF54. Am...
The experimental criteria, principally GLC behaviour and spectroscopic data, by which ω-cycloalkyl fatty acids (cyclobutyl to cycloheptyl, C14 to C21) can be identified, are described.
A novel B1 antagonist core was utilized and the effects of modification of its amide side chain on the biological activity were tested. The imino functional group of isoquinolin-1-ylacetic acid and its 6,7-dimethoxy variant was sulfonylated (4-toluenesulfonyl), while the acetyl side chain was co...
A method is described for the identification of molecular species of acylphosphatidylglycerols containing a branched cyclo fatty acid ((S)-11-cycloheptyl-4-methylundecanoic acid; brc19:0) from Alicyclobacillus acidoterrestris and its identification as picolinyl ester by means of GC–MS. The comb...
Laboratory experiments were carried out to determine the long-term effects of N-acyl-homoserine lactone (AHL)-based quorum sensing on the characteristics of ANAMMOX granules in high-loaded reactors. Results clearly showed that adding 30 mg L−1 N-octanoyl-DL-homoserinelactone (C8-HSL) at the init...
The Resonance-enhanced two-photon ionization (R2PI) and Mass-analyzed threshold ionization (MATI) spectra of 4-chloro-3-fluoroanisole (4Cl3FA) were recorded in detail. The experimental and calculated results revealed that cis and trans 4Cl3FA are the only two stable conformers in each of the S0,...
The ab initio and density functional theory (DFT) calculations reveal that two rotamers, denoted by cis and trans 3-chloro-5-fluoroanisole (3C5FA), are stable for each of the S0, S1, and D0 states. In the one-color resonant two-photon ionization (R2PI) spectra, the band origins of the S1 ← S0 e...
The structure and vibrations of 3,5-difluoroanisole (3,5-DFA) in the first electronically excited (S1) state were studied by mass-analyzed resonant two-photon ionization (R2PI) technique as well as the quantum chemical calculations. The ab initio and density functional theory (DFT) calculations ...
A branched-chain, fluorocarbonaceous, silane-bonded silica gel material for high-performance liquid chromatography (HPLC) has been developed. New columns were found to have a high ability to recognize halogen-containing molecules and separate geometrical isomers of halogen-containing phenols. Th...
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