The ligand 2-(2-chloro-5-nitrophenyl)imidazo[4,5-f][1,10]phenanthroline(CNOIP) and its complexes [Co(bpy)2(CNOIP)]3+ (1) and [Co(phen)2(CNOIP)]3+ (2) (bpy=2,2′-bipyridine; phen=1,10-phenanthroline) have been synthesized and characterized. Binding of the two complexes with calf thymus DNA has be...
An unusual base-promoted transformation of readily available 4-(2-chloro-5-nitrophenyl)-1,2,3-thia- and selenadiazoles affords a convenient approach toward benzo[b]thiophenes and benzo[b]selenophenes.
The molecular structural parameters and vibrational frequencies of 5-chloro-N-(3-nitrophenyl)pyrazine-2-carboxamide have been obtained using density functional theory technique in the B3LYP approximation and CC-pVDZ (5D, 7F) basis set. Detailed vibrational assignments of observed FT-IR and FT-Ra...
The use of 1,1′-oxalyldiimidazole, (im)COCO(im), for the synthesis of coordination complexes is explored for the first time. The [Cu2(O2CMe)4(H2O)2]/(im)COCO(im) reaction system in 96% EtOH yields the new, 1D coordination polymer [Cu(ox)(Him)2]n (1), where Him is the neutral imidazole and ox2− ...
In order to rapidly and simultaneously quantify and screen trace levels of multiple biomarkers in a single sample, rapid 1,1′-oxalyldiimidazole chemiluminescence (ODI CL) was applied as a biosensor of immunoassays using various enzymes such as alkaline phosphatase (ALP) and horseradish peroxidi...
Highly sensitive biosensor with 1,1′-oxalyldiimidazole chemiluminescence (ODI-CL) detection was developed to rapidly quantify Vibrio (V) parahaemolyticus without time-consuming procedures such as multiple long-incubations and washings. When V. parahaemolyticus in Tris–HCl (pH 7) and hairpin DN...
Emission from two different peroxyoxalate chemiluminescence (PO-CL) reaction pathways (i.e., 1,1′-oxalyldiimidazole (ODI) and bis(2,4,6-trichlorophenyl)oxalate (TCPO) CL reactions) is significantly reduced in the presence of increasing Cu2+ concentrations. The CL intensity decrease in the ODI-C...
Trace levels of microRNA-205, known as a biomarker of lung cancer, in human serum was quantified for the first-time using G-quadruplex DNAzyme linked to detection complementary probe and 1,1’-oxalyldiimidazole chemiluminescence (ODI-CL). First, capture complementary probes immobilized on the su...
The interaction of trypsin and benzamidine causes changes in their ultraviolet absorption spectra; the spectral changes are measured by difference spectroscopy, and it appears that both components contribute to the difference spectrum. The dependence of the height of a difference peak at 248 mμ...
A convenient synthesis of 1,5-fused 1,2,4-triazoles from readily available N-heteroaryl benzamidines is reported. The reaction is efficiently promoted by trichloroisocyanuric acid to afford the desired products, mostly in high yields and in relatively short time, through direct metal-free oxidat...
The response to cis-dichlorobis(cyclopentylamine)platinum(II) (cis-PAD) an antitumour platinum complex, was studied in two strains of murine lymphoma L5178Y cross-sensitive to X-rays and UV light. Dose-survival relationship, DNA synthesis, formation of chromatid aberrations, progression through ...
Novel [LnMCl2] complexes (Ln = LA, LB; M = Co, Cu, Zn) containing the N,N-chelating ligands N,N-bis((1H-pyrazol-1-yl)methyl)cyclopentanamine (LA) and N,N-bis((3,5-dimethyl-1H-pyrazol-1-yl)methyl)cyclopentanamine (LB) have been synthesized and characterized. The X-ray crystal structures of the Co...
Two strains of L5178Y murine lymphoma, inversely cross-sensitive to X-rays and UV light, were shown previously to respond to treatment with an antitumour platinum complex, cis-dichlorobis(cyclopentylamine)-platinum(II) (cis-PAD), in a similar manner as to UV.Enhancement of chromosomal damage and...
The first total synthesis of enantiopure methyl (3aR,4S,5S,6R,6aS)-4-benzyloxycarbonylamino-6-hydroxy-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxole-5-carboxylate has been carried out according to our recent novel strategy for the transformation of nitrohexofuranoses into cyclopentylamine...
As a novel and heterogeneous catalyst, the Ca2CuO3/CaCu2O3/CaO nanocomposite was synthesized via coprecipitation and thermal decomposition methods using CuSO4 and eggshell wastes as inexpensive starting materials. The catalytic activity of the mesoporous mixed metal oxide in the synthesis of 2H-...
Two novel donor–acceptor (D–A)-type conjugated polymers of PTTPPz-BDT and PTTPPz-BDTT were successfully synthesized by Stille coupling polymerization, in which 7,8-dialkoxy benzo[1,2-b:4,5-b′]dithiophene (BDT) and 7,8-bithienyl benzo[1,2-b:4,5-b′]dithiophene (BDTT) were used as donor units, ...
A new, solution processable and highly luminescent compound (photoluminescence QY ca. 60%), namely di(alkylthienyl) substituted benzo[h]benz[5,6]acridino[2,1,9,8-klmna]acridine, abbreviated as (FTC-8) was synthesized. FTC-8 is electrochemically active showing a quasi-reversible redox couple at n...
Diazines and their benzo derivatives play an important role in organic chemistry. The applications of these compounds span from medicinal chemistry to electrochemistry. Each year new syntheses, reactions, and applications of diazine-based compounds are reported. Natural products containing these...
Cyclic voltammetry data were obtained for eight phenazines and phenazine-N-oxides, and eleven quinoxalines and quinoxaline-N-oxides: 1,6-phenazinediol-5,10-dioxide (iodinin), iodinin copper complex, 6-methoxy-1-phenazinol-5,10-dioxide (myxin), myxin copper complex, 1,6-dimethoxyphenazine-5,10-di...
Found in natural products, and frequently used as flavoring agents or as building blocks for pharmaceuticals, diazines and their benzo derivatives possess a diverse set of properties, allowing abroad range of applications, spanning from medicinal chemistry to electrochemistry. New diazine-based ...
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