The reaction of N-(ethoxycarbonyl)methyl substituted ethyl 6,7-difluoro-, 6,7,8-trifluoro- and 5,6,7,8-tetrafluoro-4-oxo-1,4-dihydroquinoline-3-carboxylates with methyl methacrylate results in the [3 + 2] adducts, hexahydropyrrolo[1,2-a]quinolones, which can be precursors of [a]-fused fluoroquin...
The present study examined the cytotoxicity, anti-cancer reactivity, and immunomodulatory properties of new synthetically prepared fluoroquinolone derivative 6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (6FN) in vitro. The cytotoxicity/toxicity studies (concentrations in the range 1...
We present here two new methods based on rearrangement reactions to obtain novel 2-substituted 3-hydroxy-4-oxo-1,4-dihydroquinolines, an important family of heterocycles with potential applications. Alkyl 3-hydroxy-4-oxo-1,4-dihydroquinoline-2-carboxylates were obtained by alkoxide promoted rear...
Developing new therapeutic strategies to overcome drug resistance of cancer cells is an ongoing endeavor. From among 2 million chemicals, we identified ethyl 4-oxo-2-phenyl-1,4-dihydroquinoline-6-carboxylate (AS1712) as a low-toxicity inhibitor of lung cancer cell proliferation and xenograft tumo...
With the time-correlated single-photon counting technique, the dynamic behaviour of the excited singlet state of the title compound has been investigated under various conditions. In poly(methyl methacryiate) (PMMA) it exhibits temperature-dependent multi-exponential decays, mostly two exponenti...
Catalytic behaviour of vanadium oxide systems (5–20 wt.% V2O5) supported on TiO2–Sepiolite (with titania loading around the theoretical monolayer, 12 wt.%, 12Ti–Sep) and, as reference, on Sepiolite calcined (Sepc) in the p-substituted toluene derivatives selective oxidation was studied. In al...
Oxalyl chloride, (0.5 equiv) was found to cleave the PMB group from alkyl, aryl PMB ethers, and esters to give corresponding alcohol and acid in good yields. This method offers simple and efficient protocol for the selective deprotection of PMB ether and ester in DCE at ambient temperature.
In recent decades, the production of palatinose has aroused great interest since this structural isomer of sucrose has an interesting potential. Using immobilized in chitosan Serratia plymuthica cells, a complete conversion of concentrated sucrose solutions into palatinose was achieved in a “ba...
In recent decades, the production of palatinose has aroused great interest since this structural isomer of sucrose has a promising potential. Using immobilized in a hollow-fibre membrane reactor Serratia plymuthica cells, a complete conversion of concentrated sucrose solutions into palatinose wa...
Sucrose isomerase (SIase) has been used to produce palatinose, a structural isomer of sucrose, which has many beneficial health properties, such as low-glycemic and low-insulinemic indices. A gene corresponding to SIase from Enterobacter sp. FMB-1 was expressed in Lactococcus lactis MG1363 using...
Response surface methodology (RSM), based on multivariate non-linear model, was applied to study the interactions and optimization of the immobilization parameters for cell entrapment, namely alginate concentration, cell loading and bead diameter using Erwinia rhapontici NCPPB 1578 that produced...
Palatinose is a non-cariogenic disaccharide obtained from the enzymatic conversion of sucrose, used in food industries as a sugar substitute. Free and Ca-alginate immobilized cells of Erwinia sp. D12 were used to produce palatinose from sucrose. Palatinose production was studied in a repeated-ba...
Palatinose (isomaltulose, 6-O-α-d-glucopyranosyl-d-fructose) is a structural isomer of sucrose with very similar physico-chemical properties. Due to its non-cariogenicity and low calorific value it is an ideal sugar substitute for use in food production. Palatinose is produced on an industrial ...
ObjectiveDietary interventions with a low glycemic index have shown to be successful for the prevention and therapy of the metabolic syndrome. In the present study, we investigated the postprandial metabolic response at rest and during physical activity the low glycemic carbohydrate isomaltulose...
Addition of sweetening agents, particularly carbohydrates has been the common approach to enhance food taste. Sucrose is an extensively used since ages. However, sucrose consumption is associated with raising health concerns in the consumers of modern world. As a result, food researchers are loo...
Acceptor specificity for intermolecular transglucosylation reaction of amylomaltase from Corynebacterium glutamicum was investigated using starch as glucosyl donor and various saccharide acceptors. Maltooligosaccharides (G1–G4), mannose, palatinose and sucrose were efficient acceptors; the best...
Palatinose is a sucrose analog with a slower digestion rate than that of sucrose. For this reason, palatinose shows better effects on hepatic lipogenesis and cholesterol homeostasis compared with sucrose. We hypothesized that supplementation with palatinose instead of sucrose improves postprandi...
Two novel dioxygen heptaoxomolybdates K5[Mo7O22(O2)(OH)]Cl·6H2O (1) and K5[Mo7O22(O2)(O2)]·8H2O (2) were isolated from the solution of peroxo molybdate accidently. The solids were characterized by IR, EPR and X-ray single crystal analysis. Complex 1 contains a superoxo group with a short bond ...
A novel combination of magnetic adsorptive and coagulative strategy which was applied to remove molybdenum (Mo) ions from surface water was investigated in this study. The ferromagnetic nanoclusters and ferromagnetic nanoclusters-ferric flocs composite coagulant were characterized in terms of ty...
FeMoTeO mixed oxides have been synthesized and tested as catalysts for the oxidation of propene into acrolein. In order to determine the role of their constituent metallic elements, these catalysts were characterized using bulk techniques such as TEM, XANES and Mössbauer spectroscopy, as well as...
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