The total synthesis of (−)-codonopsinine (1) from the readily available (S)-3-chloropropan-1,2-diol is described. The key steps for the preparation of (−)-codonopsinine (1) involve the regioselective and diastereoselective amination of anti-1,2-dibenzyl ether 11 using chlorosulfonyl isocyanate a...

Circulating tumor cell (CTC) assay is one of the emerging “liquid biopsy” for cancer's diagnostic, an easy-to-operate and state-of-the-art CTC sensor is the imperative need of clinical medical laboratory. A label-free and solid-state sensor for clinical sample's CTC detection based o...

Photodynamic therapy (PDT) employing exogenous photosensitizers is currently being approved for treatment of basal cell carcinoma (BCC). 2-(4-Aminophenyl)benzothiazoles (6) consist of chromophoric structure and absorb light in the UVA (315–400 nm). These results encouraged us to design and synt...

Novel polar, electroactive N4 macrocycle with four benzimidazole units covalently substituted to the periphery of the Cobalt(II)phthalocyanine complexes have been reported for the first time. Cobalt phthalocyanine with tetra[β-(2-benzimidazole)] and tetra[β-(2-(1-(4-aminophenyl))benzimidazole)...

In the present study antitumor effect of 2-(4-aminophenyl) benzothiazole (BTZ) was evaluated against human U251 and rat C6 glioma cell lines using MTT assay. It was observed that BTZ exhibited significant antitumor effect with IC50 of 3.5 and 4 µM against human U251 and rat C6 glioma cells resp...

As a potential pandemic threat to human health, there has been an urgent need for rapid, sensitive, simpler and less expensive detection method for the highly pathogenic influenza A virus. For this purpose, Quartz Crystal Microbalance (QCM) and Surface Plasmon Resonance (SPR) sensors have been d...

The β-carboline alkaloids are a large group of naturally occurring and synthetic indole alkaloids with remarkable pharmacological properties. Furthermore, these alkaloids have also been reported to be effective agents for controlling many pests and plant pathogenic nematodes. However, studies o...

A convenient microwave-assisted methodology is developed for the generation of 5-chloro-3-(dimethylamino)pyrazin-2(1H)-ones. The method entails a chemoselective desulfitative removal of a phenylthioether bond upon DMF/H2O treatment in the presence of sodium carbonate, yielding the desired compou...

We report here the preparation of 2-hydroxy-4-(picolinamido)benzoic acid and its aspirin analogue 2-acetoxy-4-(picolinamido)benzoic acid. Both ligands were used to synthesize organoruthenium and -osmium complexes. The compounds were characterized by NMR spectroscopy, electrospray ionization mass...

PurposeTo assess the predictability, efficacy, safety, and complications of the PRL (CIBA Vision) phakic intraocular lens (pIOL) in the correction of high myopia.

Some C5 mono- and diester-substituted 1-pyrroline-1-oxides have been prepared via reductive cyclisation of the corresponding γ-nitro carbonyl compounds. Ethyl 2-phenyl-1-pyrroline-1-oxide-5-carboxylate 5c was regioselectively alkylated at C5. Acylation of this molecule occurs exclusively on the...

Ion–ion and ion–solvent interactions for N,N/-ethylene-bis(salicylideneiminato)-diaquochromium(III) chloride, [Cr(salen)(H2O)2]Cl, dissolved in solutions of 1-butyl-2,3-dimethylimidazolium tetrafluoroborate, [bdmim]BF4 (0.005 to 0.020 mol · dm−3) in methanol (MeOH) were investigated by a comb...

The aggregation behavior of an anionic surfactant sodium dodecylsulphate (SDS) in aqueous system in the presence of 1-butyl-2,3-dimethylimidazolium tetrafluoroborate [bdmim][BF4], a trisubstituted ionic liquid (IL) has been studied. Critical micelle concentrations (cmcs) were determined from con...

The aggregation behavior of a conventional cationic surfactant, tetradecyltrimethylammonium bromide (TTAB), in a trisubstituted imidazolium based hydrophilic ionic liquid (IL), 1-butyl-2,3-dimethylimidazolium bromide [bdmim][Br]/water systems was investigated by conductance, fluorescence, 1H NMR...

Electrochemical behaviour of Ti(IV) species in the ionic liquid (IL) 1-butyl-2,3-dimethylimidazolium tetrafluoroborate (BMMImBF4) was studied by means of chronopotentiometry (CP) and cyclic voltammetry (CV) in melts with different concentrations of TiF4 (2–35 mol%) within a temperature range of...

Micellization behaviour of cetyltrimethylammonium bromide (CTAB) in the presence of ionic liquid (IL), 1-butyl-2,3-dimethylimidazolium bromide [bdmim][Br] in aqueous medium has been investigated by conductance, fluorescence, 1H NMR, dynamic light scattering (DLS) and transmission electron micros...

The micellization behaviour of cationic surfactant dodecyltrimethylammonium bromide (DTAB) has been studied upon addition of 1-butyl-2,3-dimethylimidazolium chloride, [bdmim][Cl], a trisubstituted imidazolium based ionic liquid (IL) in aqueous media. The critical micelle concentration (cmc) and ...

Effect of 1-butyl-2,3-dimethylimidazolium chloride [bdmim][Cl], a trisubstituted ionic liquid on the critical micelle concentration (cmc) of sodium dodecylsulphate (SDS) in aqueous medium have been studied using conductometry from 298.15 to 318.15 K and pyrene fluorescence probe analysis at 298....

Conductivities, densities and speeds of sound of 1-butyl-2,3-dimethylimidazolium chloride in aqueous solutions were measured at 15, 25, and 35 °C. These data have been used to characterize the aggregation process of imidazolium based ionic liquid in the aqueous solution. The critical aggregatio...

Although FPR2 receptor is distributed in the endometrium and placenta, its function in human extravillous trophoblastic (TEV-1) cells still remains enigmatic. In this study, overexpression of FPR2 was performed in TEV-1 cells. Then, CCK8 transwell and wound healing assays were used to assess the...