Bitter sensation is mediated by various bitter taste receptors (T2Rs), thus T2R antagonists are actively explored. Our objective was to look for novel T2R blockers in hen protein hydrolysate (HPH). We screened the least bitter HPH fractions using electronic tongue, and analyzed their peptide seq...

Unfriendly temperature profiles and costs of carbon coupling catalysis, which pose challenge to both synthetic organic chemists as well as industrial applicability, motivated our design of new monodentate N-donors as support ligands for the purpose of constructing ambient temperature precatalyst...

3-Methyl-1a,7b-dihydro-1H-cycloprop[c]isoquinoline is formed from trans-2-(2-acetylphenyl)cyclopropylamine generated in situ. The mechanism for this reaction appears to involve the formation of a cis-arylcyclopropylamine via a homoconjugated intermediate.

The asymmetric 1,3-disubstituted biaryl triazene 1-(4-amidophenyl)-3-(4-acetylphenyl)triazene (1) and the corresponding complex [1-(4-amidophenyl)-3-(4-acetylphenyl)triazenido-κN3](triphenylphosphane-κP)gold(I) (2) were characterized by single-crystal X-ray structure analysis and, the antibact...

The electrochemical behaviour of 3-cyano-5-methoxycarbonyl-2,6-dimethyl-4(o-nitrophenyl)-1,4-dihydropyridine and the corresponding N-methyl derivative have been investigated in hydroalcoolic medium. The 4 electron reduction leads to an amino-benzonaphtyridine N-oxide (cyclization from the reacti...

A comprehensive study of the electrochemical reduction in protic media of parent C-4 nitrophenyl 1,4-DHPs and their corresponding nitrosophenyl 1,4-DHPs was carried out. The reduction potentials of synthesized aromatic nitro compounds were compared with those of the corresponding nitroso compoun...

Si-MCM-41, Ga-MCM-41 and Al-MCM-41 mesoporous catalysts (with Si/Al = 80 and Si/Ga = 80) were prepared by direct synthesis under hydrothermal crystallization method using sodium aluminate or gallium sulfate and tetraethyl orthosilicate (TEOS) as aluminum or gallium and silica sources, respective...

This paper reports the synthesis of 2-(4-hydroxyphenyl)ethyl and 2-(4-nitrophenyl)ethyl substituted benzimidazolium salts. The benzimidazolium salts were synthesized by N-substituted benzimidazolium and aryl halides. The 2-(4-hydroxyphenyl)ethyl and 2-(4-nitrophenyl)ethyl substituted benzimidazo...

Routes to single enantiomers of hydroxy, methoxy and ketomycolic acids containing an α-methyl-trans-alkene unit as well as related trehalose, glucose, arabinose and glycerol esters are described. In serodiagnostic assays to detect antibodies to mycobacterial lipids, the trehalose esters give hi...

The synthesis of mycobacterial mycolic acid related wax esters and of their trehalose di- and mono-esters is described. The trehalose dimycolates (TDMs) synthesised activated bone marrow derived dendritic cells (BMDCs) in vitro more strongly than trehalose dibehenate or the trehalose monomycolat...

Twenty-eight newer 3-benzofuran-5-aryl-1-pyrazolyl-pyridylmethanone and 3-benzofuran-5-aryl-1-pyrazolylcarbonyl-4-oxo-naphthyridin analogs were synthesized by microwave irradiation method and evaluated for in-vitro and in-vivo antitubercular activity against multidrug-resistant M. tuberculosis s...

Acid washing is an alternative and promising approach for biomass to produce high-quality bio-oil. The hydrochloric acid washing pretreatment of sweet sorghum bagasse was performed in this study. The effects of acid washing on the ultrastructure of sweet sorghum bagasse were investigated using s...

Inorganic pyrophosphatases are potential targets for the development of novel antibacterial agents. A pyrophosphatase-coupled high-throughput screening assay intended to detect o-succinyl benzoic acid coenzyme A (OSB CoA) synthetase inhibitors led to the unexpected discovery of a new series of n...

The alkaloid juliflorine (1) from Prosopis juliflora inhibited acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) enzymes in a concentration-dependent fashion with IC50 values 0.42 and 0.12 μM, respectively. Lineweaver–Burk as well as Dixon plots and their sec...

Solid polymer electrolytes consisting of poly(propylene glycol) diacrylate and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) were deposited onto Cu2O-coated 3D Cu nano-pillars through cathodic electropolymerization. Electropolymerization, using constant and pulsed current techniques, was u...

Monooxides of 2,2′-bis(alkylthio)biphenyl undergo facile monodealkylation on treatment with triflic anhydride to afford the corresponding thiasulfonium salts except bis(methylthio) derivative. The reaction proceeds via an initial formation of the corresponding dithiadications.

Condensation of carboxaldehydes with appropriate secondary propargylamines furnishes iminium ions which undergo regioselective deprotonation at the propargylic methylene group to generate azomethine ylides. Interception of the latter by N-methyl or N-phenyl maleimide furnishes 2- and 2,5-dialkyn...

Low temperature infrared absorption spectra of yttrium orthoaluminate and lutetium orthoaluminate bulk crystals and liquid phase epitaxy grown single crystalline films doped with Ce3+ are presented. In the region of intra-configurational 4f – 4f transitions the spectra indicate the existence of...

We report on the optical properties of Ce:LLF excited by the 61-nm wavelength emission of the SPring-8 compact self amplification of spontaneous emission source (SCSS) test accelerator, which is a prototype self-amplified stimulated emission (SASE)-type free electron laser (FEL) that emits extre...

Lutetium oxyorthosilicate (LSO) exists in two different crystallographic phases, both with the monoclinic structure. The low-temperature polymorph, referred to as A-type LSO (A-LSO), crystallizes in space group P21/c, whereas the high-temperature polymorph, referred to as B-type LSO (B-LSO), cry...