Reaction energetics of the double (2H+/2e−), i.e., the first 1H+/1e− (catechol → phenoxyl radical) and the second 1H+/1e− (phenoxyl radical → quinone) free radical scavenging mechanisms of quercetin and its six colonic catecholic metabolites (caffeic acid, hydrocaffeic acid, homoprotocatechuic...

A mild and efficient trifluoromethylselenolation of acid chlorides with [(bpy)Cu(SeCF3)]2 (1) in the presence of a catalytic amount of metallic iron powder is described. Easily available benzoyl chloride derivatives and alkyl acid chlorides are smoothly converted into the corresponding Se-triflu...

Six-, five-, four- and three-membered 1,1-cycloalkanedicarboxylic acid (2a–d) were synthesized by alkaline hydrolysis of the corresponding diesters (1a–d) and the reactions of the formers with SF4 were investigated. 1,1-Bis(trifluoromethyl)cycloalkanes (3a–d) were the products of the reaction...

Formation equilibria of copper(II) complexes of 2-(aminomethyl)-benzimidazole (AMBI) and the ternary complexes Cu(AMBI)L (L = amino acid, amide, dicarboxylic acid or DNA constituents) have been investigated. Ternary complexes of amino acids or amides are formed by a simultaneous mechanism. Amino...

An investigation on Bidens parviflora led to the isolation of three sucrose esters and a substituted truxillate. Their structures were elucidated as (6-O-(E)-p-coumaroyl)-β-d-fructofuranosyl-(2→1)-α-d-glucopyranoside, (6-O-(E)-p-coumaroyl)-β-d-fructofuranosyl-(2→1)-(6-O-(E)-p-coumaroyl)-α-...

In the present study, we report electrosynthesis of 4,5-bis(4-chloroanilino)-1,2-benzendiol (BCB) and its application as a selective electrochemical mediator at a surface of carbon paste electrode (CPE) modified ZnO/CNTs nanocomposite as a simple and rapid voltammetric sensor. The sensor showed ...

The chemiluminescence (CL) arising from reaction of bis(2,4,6-trichlorophenyl)oxalate (TCPO) with hydrogen peroxide in the presence of a brightener 5-(3-anilino-5-chloroanilino)-2-{(E)-2-[4-(3-anilino-5-chloroanilino)-2-sulfophenyl]-1-ethenyl}-1-benzenesulfonic acid (Bri) has been studied. The r...

We have synthesized a new narrow bandgap alternating polyfluorene copolymer (PFTTDIONE) based on 2,7-dibromo-9,9-dioctylfluorene, 2,5-bis-(tributyl-stannyl)thiophene, and 2,6-bis-(5-bromo-3-hexyl-thiophen-2-yl)-anthraquinone (M1), via a Stille polymerization reaction. The optical properties, ele...

The canonical Wnt signaling pathway plays a fundamental role in embryonic as well as in adult development. Consequently, dysregulation of the pathway has been linked to a wide spectrum of pathological conditions. In a program aimed at the identification of small molecule inhibitors of the canoni...

Dielectric elastomers (DEs) are a promising new transducer technology, but high driving voltages limit their current commercial potential. One method used to lower driving voltage is to increase dielectric permittivity of the elastomer. A novel silicone elastomer system with high dielectric perm...

Shigella flexneri serotypes 6 and 6a are closely related bacteria causing shigellosis in humans. Their O-antigens are {→4)-β-d-GalpA-(1→3)-β-d-GalpNAc-(1→2)-[3Ac/4Ac]-α-l-Rhap-(1→2)-α-l-Rhap-(1→}n acidic polysaccharides ({ABAcCD}n), which only differ in the degree of O-acetylation. A co...

The synthesis of the four optical isomers of known absolute configuration of O-2-butyl S-2-(dimethylammonium)ethyl ethylphosphonothioate hydrogen oxalate is described. Values for the affinity constant (Ka), phosphonylation constant (kp), and bimolecular inhibition rate constant (ki) for the inhi...

The synthesis of a series of thirty-eight new modified dinucleotides and dinucleotide conjugate analogues of d-5′ApC3′ is described. The inhibitory activity of these compounds toward HIV-1 integrase was examined in enzymatic assays using the natural dinucleotide as a reference. Among the compo...

The screening of the HIV-1 protease (PR) inhibitory activity (IC–50) of various substituted 3-phenyl-4-hydroxycoumarins, 3-benzyl-4-hydroxycoumarins, 3-phenoxy-4-hydroxy-coumarins, 3-benzenesulfonyl-4-hydroxycoumarins and 3-(7-coumarinyloxy)-4-hydroxycoumarins was performed. The data indicate t...

ObjectivesThis study genotyped oral isolates of Candida albicans and C. dubliniensis by analyzing 25S rDNA transposable intron and evaluated their virulence attributes in oral candidiasis.

BackgroundThe presence of intron 25S allows to divide the Candida albicans species into three subclasses (A, B, C). Intronless and intron harboring strains were reported to have different susceptibility to some drugs, for example to flucytosine and bleomycin.

In order to find an explanation of the low acute toxicity of di-(2-chloroethyl) aryl phosphates and their variable ataxic toxicity in sheep, the reactions of these compounds with various esterases found in sheep were studied, and compared with those of other, more toxic compounds.Di-(2-chloroeth...

The tri-n-butyltin(IV) complexes of 2-[(E)-2-(3-formyl-4-hydroxyphenyl)-1-diazenyl]benzoic acid and 4-[((E)-1-{2-hydroxy-5-[(E)-2-(2-carboxyphenyl)-1-diazenyl]phenyl}methylidene)amino]aryls (aryls = 4-CH3, 4-Br, 4-Cl, 4-OCH3) have been synthesized and characterized by 1H, 13C, 119Sn NMR, IR and ...

Three new copper (II) complexes viz. [Cu(L1)(bipy)]⋅2H2O 1, [Cu(L1)(dmp)]⋅CH3CN 2, [Cu(L1)(phen)] 3 where L1H2 = 2-{[(Z)-(5-bromo-2-hydroxyphenyl)methylidene]amino}benzoic acid, bipy = 2,2′-bipyridine; dmp = 2,9-dimethyl 1,10-phenanthroline, phen = 1,10-phenanthroline have been synthesized and ...

A series of new pyrazolo[3,4-b]pyridin-3-yl pyrimidine derivatives were synthesized and evaluated for the activation of sGC. Compared with riociguat, compound 13a exhibited equivalent in vitro activity on preconstricted rat thoracic aorta rings and in Rat heart Langendorff preparation. Compound ...