Bovine parathyroid hormone (PTH) 1–34 [bPTH(1–34)] and human PTH related protein [hPTHrP(1–34)] stimulated cAMP accumulation in opossum kidney (OK) cells with Km of 5 × 10−9M, but inhibition of phosphate uptake was obtained with 17-fold lower Km of 3 × 10−10M. Phosphate uptake was partially...

Synthetic bovine parathyroid hormone containing the NH2 terminal 34 amino acids [bPTH-(1–34)] was recently demonstrated to inhibit oxytocin stimulated uterine contraction in vitro. The parathyroid hormone analogues [Nle8, Nle18, Tyr34]bPTH-(3–34)amide [NTA-(3–34)] and [Tyr34]bPTH-(7–34)amide...

A new class of 3′-deoxy-3β′-fluoro-3α′-C-hydroxymethyl-pyrimidine 1a-c and purine 1d nucleosides were synthesized using modified Corey-Link reaction with 3-oxo-d-glucofuranose derivative to get C-3 quaternary carbon with 3β′-fluoro-3α′-C-hydroxymethyl groups, in the sugar frame work. Co...

Cocrystallization of the commonly available organic primary amine, tris(hydroxymethyl)aminomethane (L), with 2-furoic acid (Hfura), isonicotinic acid (Hinic), 4-aminobenzoic acid (Haba), 2,4-dichlorobenzoic acid (Hdcba), 4-chlorophenoxyacetic acid (Hcpa), 1,4-cyclohexanedicarboxylic acid (H2cha)...

The reaction of dimethyl (1-aryl-1-hydroxymethyl)phosphonates with 1-chloro-3-phospholene 1-oxides, diphenylphosphinic chloride or diphenyl chloridophosphonate affords the corresponding (1-phosphoryloxymethyl)phosphonates. The products with two different >P(O)– moieties exhibit characteristic δ...

Herein we report the synthesis and X-ray characterization of a neutral mercury(II) complex of composition [Hg(L)2]n (1), [L = N1-(3-hydroxypropyl)-5-fluorouracilate]. The Hg(II) is bound to the N(3) atoms of both ligands in an essentially linear geometry. Mercury also interacts through short con...

Comprehensive structure activity relationship (SAR) studies were conducted on a focused screening hit, 2-(methylthio)-3-(phenylsulfonyl)-4H-pyrido[1,2-a]pyrimidin-4-imine (1, IC50: 4.0 nM), as 5-HT6 selective antagonists. Activity was improved some 2–4 fold when small, electron-donating groups ...

Exposure to high or repeated doses of methamphetamine can cause hyperthermia and neurotoxicity, which are thought to increase the risk of developing a variety of neurological conditions. Sigma receptor antagonism can prevent methamphetamine-induced hyperthermia and neurotoxicity, but the underly...

A series of thirty-six novel 5-(2-(4-(benzo[d]isoxazol-3-yl)piperazin-1-yl)acetyl)indolin-2-one and 5-(2-(4-substitutedpiperazin-1-yl)acetyl)indolin-2-one analogues were synthesized, characterized and screened for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv s...

Reaction of 2-amino-4, 6- dimethyl pyrimidine with carboxylic acid such as gallic acid and pimelic acid, yielded a salt and co-crystal, respectively. The new crystal forms were obtained from slow evaporation technique. The crystal structure and hydrogen bond interaction of the two crystals were ...

The structures of several azo-benzoic acids, 4-[((E)-1-{2-hydroxy-5-[(E)-2-(aryl)-1-diazenyl]phenyl}methylidene)amino]benzoic acid along with their precursors 2-hydroxy-5-[(E)-(aryldiazenyl)]benzaldehydes were confirmed using 1H, 13C NMR, UV–VIS and IR spectroscopic techniques. UV–VIS absorpti...

Potassium amyl xanthate (PAX) and sodium isobutyl xanthate (SIBX) are commonly used collectors in both the bulk and selective froth flotation of sulfide ores. These thiol xanthate collectors are conventionally mixed together as well as with more selective thiol collectors such as dithiophosphate...

The extraction of phenols from coal chemical industry wastewater with methyl propyl ketone was studied in this work by experimental determination and process simulation. Phenol and hydroquinone were separately selected as the representatives of phenolic pollutants in the phenols-containing coal ...

The role of gangue minerals including quartz and calcite slimes in the sulfidization flotation of malachite was investigated by micro-flotation tests, sedimentation analysis, zeta potential distribution measurements and DLVO calculations. The micro-flotation results showed that calcite slime dep...

In order to eliminate the adverse effects of calcite slimes on the sulfidization-xanthate flotation of malachite, water glass was used as a depressant for calcite slimes. Micro-flotation results indicated that the floatability of malachite was restored in mixed malachite and calcite by adding wa...

Effects of sodium chloride on the sulfidization flotation of cerussite (PbCO3) were investigated by micro-flotation tests, adsorption tests and zeta potential measurements. The micro-flotation test results indicated that sodium chloride effectively improved the sulfidization flotation performanc...

The effect of calcite on malachite sulfidization flotation was investigated by micro-flotation tests, adsorption, sedimentation and zeta potential test. The micro-flotation results showed that the finer the calcite particles size is, the lower the malachite recovery will be in the sulfidization ...

Although flotation and bio-extraction of metals from its products are extensively investigated, there are few studied which evaluated the effects of reagents on bioleaching process. Both structure and concentration of flotation reagents are effective factors on microorganism activities. In this ...

The synthesis of a novel scaffold for the simple and high-yielding polymer-assisted solution phase preparation of arrays of 2′-amido-2′-deoxy-N6-(1-naphthylmethyl)adenosine derivatives 10a–h as analogues of a known inhibitor of trypanosomatid glycosomal glyceraldehyde-3-phosphate dehydrogenas...

d-Glucose, l-xylose, and d- and l-arabinose were sources of chirality to obtain four enantiomerically pure 3-hydroxy-2-methylbutanoic acids, which were reacted with 2-naphthyldiazomethane to furnish their fluorescent 2-naphthylmethyl esters.