The composition of cutin from stem tissue of Pisum sativum var. Meteor in normal plants and those in which stem extension had been induced with gibberellic acid was determined by capillary GC-chemical ionization mass spectrometry, the first application of the technique to this lipid phytopolymer...

Sequential microwave assisted HCl hydrolysis and tetramethylammonium hydroxide (TMAH) hydrolysis (in MeCN at 140 and 190 °C) were used to analyze the hydrolysable constituents of soil organic matter (SOM) from a forest soil. At each step, the organic or aqueous extracts were analyzed using gas ...

A general method was developed for the diastereoselective resolution of α-methoxy fatty acids utilizing (S)-(−)-1-(1-naphthyl)ethylamine as resolving agent. The diastereomeric amides can be easily separated by silica gel column chromatography and/or capillary gas chromatography, thus allowing f...

Numerous FLT3 inhibitors have been explored as a viable therapy for the treatment of acute myeloid leukemia (AML). However, clinical data have been underwhelming due to incomplete inhibition of FLT3 or the emergence of resistant mutations treated with these older agents. We previously developed ...

A divergent regioselective palladium (II) catalyzed approach through post Ugi cyclization is described. The Ugi adduct underwent intramolecular ortho-hydroarylation via 6-endo-dig cyclization for the direct access to 4-aryl-2-quinolones. Incorporation of iodine at the C-3 position of 2-quinolone...

Levamisole, the imidazo[2,1-b]thiazole derivative has been reported as a potential antitumor agent. In the present study, we synthesized, characterized and evaluated biological activity of its novel analogues with substitution in the aralkyl group and on imidazothiadiazole molecules with same ch...

The synthesis of several 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4-methyl-1,3-thiazolines (2a–t) was carried out by base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)-3-(fluorophenyl)thioureas (1a–t) with 2-bromoacetone in aqueous medium. The structures of th...

A novel fluorinated aromatic diamine monomer, 1,1-bis[4-(4′-aminophenoxy)phenyl]-1-[3″,5″-bis(trifluoromethyl)phenyl]-2,2,2-trifluoroethane(9FTPBA), was synthesized by coupling 3′,5′-bis(trifluoromethyl)-2,2,2-trifluoroacetophenone with 4-nitrophenyl phenyl ether under the catalysis of trif...

The separation characteristics of the trimethylsilyl ether derivatives of various naturally occurring and synthetic pteridines on a apolar glass capillary column, together with their mass spectra, permit their identification and quantitation in biological samples. Examples are given of the deter...

A novel series of etravirine–VRX-480773 hybrids were designed using structure-guided molecular hybridization strategy and fusing the pharmacophore templates of etravirine and VRX-480773. The anti-HIV-1 activity and cytotoxicity was evaluated in MT-4 cell cultures. The most active hybrid compoun...

3,6-Dimethyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one 3 was prepared by an intramolecular cyclization of N-(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl) acetamide 2 in ethanol in the presence of piperidine. N-allylation and N-propargyl alkylation of N-substituted pyrazolo[3,4-d] pyrimidin-4(...

We developed a new one-pot reaction of phenolic acids to afford the corresponding esters and amides through acyl-protected and activated phenolic acid intermediates. The simultaneous protection/activation of phenolic acids with alkylchloroformates proceeded readily in the presence of DMAP at roo...

To improve the properties of cytotoxic triterpenoid acids 1–5, a large set of hydrophilic esters was synthesized. We choose betulinic acid (1), dihydrobetulinic acid (2), 21-oxoacid 3 along with highly active des-E lupane acids 4 and 5 as a model set of compounds for esterification of which the...

In this paper we report the preparation of 5,7-dimethylpyrazolo [1,5-a] pyrimidines substituted in position 2 by a long linear perfluoroalkyl chain (C7F15). These compounds are obtained by action of acetylacetone with 5(3)-F-alkyl 3(5)-aminopyrazoles. In some cases the reaction intermediate may ...

3(5)-Amino-5(3)-hydrazinopyrazole dihydrochloride (8) reacts with pentane-2,4-dione (9a) to afford 2-(3′,5′-dimethylpyrazol-1′-yl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine (10a) instead of the 3-(3′,5′-dimethylpyrazol-1′-yl)-4,6-dimethyl-1H-pyrazolo[3,4-b]pyridine isomer (11). Similarly, the ...

The reduced form of longer-wavelength cytochrome b (b566) was identified in rat liver mitochondria in State 5 on addition of ferricyanide. Addition of menadione caused oxidation of b566 and reduction of cytochrome c1 (+ c). In the presence of menadione, ferricyanide induced reduction of b566 and...

1.Circular dichroism spectra of the cytochromes in membrane fragments derived from sonicated beef heart mitochondria have been obtained in the wavelength region 400–480 nm in which the major absorbance maxima of the heme prosthetic groups are found.2.2. Cytochrome oxidase in the mitochondrial m...

Cytochrome B is an important polypeptide of the mitochondria helpful in energy metabolism through oxidative phosphorylation. Cytochrome B plays an immense role in the reproduction of animals and due to its mutation prone nature, it can affect the basic physiology of animals. Cytochrome B affects...

Cytochrome B is the mitochondrial protein, which functions as part of the electron transport chain and is the main subunit of transmembrane cytochrome bc1 and b6f complexes affecting energy metabolism through oxidative phosphorylation. The present study was conducted to study the effect of mutat...

Nitration of N,N-diethylaniline in concentrated sulphuric acid afforded a readily separable mixture of the 3- and 4-nitro derivatives, the former being the major product. Reduction and subsequent reaction of 3-amino-N,N-diethylaniline with acid chlorides, chloroformates, isocyanates and sulphony...