In a wide research programme towards the study of piperidin-4-ones with efficient pharmacological effect, a new series of N-acyl r-2,c-6-bis(4-methoxyphenyl)-c-3,t-3-dimethylpiperidin-4-ones 2–5 are synthesized and characterized by IR spectra, 1H, 13C, DEPT - 135 and 2D (COSY and HSQC) NMR and ...

The Ni(II) complex of 1,1-diethyl-3-(2-chlorobenzoyl) thiourea (L) was synthesized and its crystal structure determined by X-ray crystallography. NiL2 is monoclinic, space group P2l/c(#14), with a=8.229, b=39.277, c=8.485 Å, β=96.8°. The Ni(II) is coordinated in a planar fashion by two S and t...

In the current work, new 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives (1–8) were synthesized via the ring closure reaction of 2-bromoacetophenone derivatives with 4-amino-5-[(5-methoxy-2-methyl-1-(4-chlorobenzoyl)-1H-indol-3-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-thione, which was obt...

.The benzo[b]furan derivative MU314 inhibits in vitro bone resorption as potently as β-estradiol (E2). Here, we examined the point of action on the anti-osteoporotic effects of MU314. MU314 (10 nM) suppressed lacunae formation by osteoclastic cells and ICI-182,780, a pure E2 antagonist, inhibit...

Mid and far-infrared vibrational spectra of Indometacin [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid], Diclofenac [[2-(2,6-dichlorophenyl)amino]-benzeneacetic acid] and Niflumic acid [2-3((3-trifluoromethyl)phenylamino)-3-pyridinecarboxylic acid] have been measured at room and...

A series of peptidomimetic human immunodeficiency virus (HIV) protease inhibitors containing substituted allophenylnorstatine (Apns: (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid) were designed and synthesized. From the structure–activity relationship of this series of compounds, SM-309515 was...

Few biological molecules have as far reaching and dynamic effects as abscisic acid (ABA). In this review, we draw together the often segregated fields of plant, animal, and human biology to highlight ABA biosynthesis, signaling and physiological effects with examples of host–pathogen interactio...

The conversion of [414C]corticosterone([14C]B) and 11-deoxy-[1,2-3H]corticosterone ([3H]DOC) to steroidal carboxylic acids was studied in the BALB/c mouse. There was rapid and preferential excretion of [3H]DOC metabolites into the gastrointestinal tract. Excretion of 14C through the kidney was h...

Acidic metabolites of injected progesterone have been isolated from rabbit urine. The acids were chromatographed on alumina and florisil columns, precipitated as salts, methylated and oxidised to give a simplified pure oxosteroid fraction. Gas chromatography on 3% SE-30 gave a major compound tha...

Corticosterone influences emotion and cognition via actions in a diversity of corticolimbic structures, including the amygdala. Since extracellular levels of corticosterone in brain have rarely been studied, we characterized a specific and sensitive enzymatic immunoassay for microdialysis quanti...

A simple convenient protocol for the synthesis of secondary amine N-(2-(substitutedphenyl)quinazolin-4(3H)-ylidene) carbothioamides and O-alkyl N-2-(substitutedphenyl)quinazolin-4(3H)-ylidene carbamothioates has been described. It involves the cascade reaction of various secondary amines or alco...

2-Cyanophenyl isothiocyanate reacted with Mn(III) acetate in acetic acid or acetonitrile to give fair yields of a new polycondensed heterocycle arising from the joining together of two molecules of the starting isothiocyanate with loss of a CS moiety. The yields were close to 90% when the reacti...

The equilibrium water vapor pressures, PH2O for the thermal dehydrations of some formate dihydrates, M(HCO2)2·2H2O, where M is Mg, Mn, Co, Ni and Zn, were measured by means of the transpiration method using a laboratory-made apparatus. These hydrates have a monoclinic isomorphous crystal struct...

The kinetics of the thermal dehydration of erbium formate dihydrate has been studied by means of isothermal gravimetry under various water vapour pressures from 5 × 10−4 to 8 Torr. The kinetics of the dehydration, on the whole, can be described by the contracting volume model, R3. The rate of d...

Two new zinc-terephthalate MOFs, (H2NEt2)[Zn3(BDC)3(HCO2)]·1.5DEF (1) and Zn4(BDC)3(HCO2)2(DEF)4 (2), based on trinuclear zinc secondary building units have been solvothermally synthesized from the well-studied MOF-5 system Zn–H2BDC–DEF (H2BDC = 1,4-benzenedicarboxylic acid or terephthalic ac...

Electron spin resonance (ESR) of Cu2+ doped cadmium formate dihydrate single crystal was studied at room temperature. Copper enters the lattice substitutionally and is trapped at two magnetically inequivalent sites. The observed spectra are fitted to a spin-Hamiltonian of rhombic symmetry with t...

The crystal structure of zinc acetate dihydrate was re-refined by X-ray diffraction analysis of the single crystal. The monoclinic cell dimensions were revised as a=14.394 (3), b=5.330 (2), c=10.962 (3) Å and β=99.8 (2)° with Z=4. The bond distances and bond angles were also refined. Based on ...

The kinetics of the thermal dehydration of zinc formate dihydrate, Zn(HCO2)2·2H2O, was studied by means of isothermal gravimetry and microscopic observations at atmospheric pressure under controlled water vapour partial pressure at 12.8 Torr. The rates of advancement of the interface establishe...

Hydrated zinc(II) formate reacts with 2,2′-bipyridine (2,2′-bpy) to form a novel zig-zag mono-dimensional coordination polymer (1D CP) [{Zn(μ-OCHO)(OCHO)(2,2′-bpy)(H2O)}·H2O]n, 1, which was structurally characterized by a single-crystal X-ray diffraction study. Title compound crystallizes i...

The isothermal dehydration of zinc formate dihydrate has been studied thermogravimetrically under various water vapour pressures from 5 × 10−4 to 6 Torr. The rate of dehydration exhibited an unusual dependence upon the water vapour pressure: with increasing water vapour pressure, the rate of de...