Microcolumn ion chromatography of inorganic monovalent and divalent cations has been investigated by using 1,1′-dimethyl-4,4′-bipyridinium dichloride as a visualization agent. The separation of sodium, ammonium, potassium, magnesium and calcium ions was completed within 20 min, and the analyte...

Rubidium and caesium may be efficiently separated in macro-quantities on columns of zirconium phosphate, at loadings up to 10 per cent, by elution with solutions of ammonium salts or of nitric acid. High yields of pure materials are obtained if the separation is performed at elevated temperature...

An organic nonlinear optical material “1-[4-(methylsulfanyl) phenyl]-3-(4-nitrophenyl) prop-2-en-1-one” (4MPNP) has been synthesized by Claisen–Schmidt condensation and crystallized by slow evaporation technique at ambient temperature. The functional groups present in 4MPNP molecule were iden...

FT-IR spectrum of 3-Methyl-4-{(E)-[4-(methylsulfanyl)-benzylidene]amino}1H-1,2,4-triazole-5(4H)-thione was recorded and analysed. The vibrational wavenumbers were computed and at HF and DFT levels of theory. The data obtained from wavenumber calculations are used to assign the vibrational bands ...

Two alternative methods for the preparation of new pyrimidine Diels–Alder cycloadducts from the readily available 2,4-bis(methylsulfanyl)-5,6-dihydrocyclobuta[d]pyrimidine are presented. In the first method, the in situ generated pyrimidine ortho-quinodimethane reacts with various dienophiles t...

The effects of substitution and charge transfer on linear and nonlinear optical absorption (especially two photon absorption) properties of aza-BODIPY containing triphenylamine, 4-ethynyl-N,N-dimethylaniline and methoxy moieties were investigated by ultrafast pump probe spectroscopy technique. F...

A novel series of silyl-yne containing chalcone derivatives 5a-5j was synthesized by exploiting Sonogashira coupling reaction and Claisen-Schimdt condensation reaction. The synthesized derivative were characterized by spectroscopic and elemental analysis. The selective inhibition of carbonic anh...

Effects of substituents on transformations of 4-(phenylethynyl)benzaldehydes and related benzaldehydes were analyzed in aldol and thiazolidine formation reactions. The aldol reaction of 4-cyanobenzaldehyde was 54-fold faster than that of 4-methoxybenzaldehyde. In contrast, the aldol reaction of ...

A [Cu(maloNHC)]-catalyzed synthesis of 2-aryl pyrazolo[5,1-a]isoquinolines via annulation of N′-(2-((trimethylsilyl)ethynyl)benzylidene)hydrazides with terminal aromatic alkynes was developed.

At 60 °C in DMSO, the iodine-catalyzed reaction of 3-aminopyrazine-2-carbohydrazide and 2-(arylethynyl)benzaldehydes led hydrazones. Increasing the reaction temperature to 100 °C, the amino and amido still indicated inactive, only the imine took part in the addition of acetylene bond to give 2...

From a series of 4’-[(trifluoromethyl)pyrazol-1-yl]carboxanilides derived from 4-methyl-4’-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide, one inhibited thapsigargin-induced Ca2+ influx in Jurkat T cells (IC50 = 77 nM) and exhibited high selectivity for the CRAC c...

For the first time, gas chromatographic (GC) stationary phases consisting of zwitterionic liquids (ZILs) possessing sulfonate functional groups were utilized for the analysis of volatile carboxylic acids (VCAs). The highly polar and acidic nature of VCAs significantly limits the number of curren...

Novel regioisomers of trifluoromethylated cyclopropanes have been synthesized by Michael addition and nucleophilic cyclization process. The reaction was carried out with the trifluoromethylcrotonate 6 and nucleophilic reagents. Fluorinated cyclopropanes were obtained with good to excellent diast...

The 2-unsubstituted imidazole N-oxides with a 3,3,3-trifluoro-2-hydroxypropyl group at N(1) in the presence of acetic anhydride undergo cyclization via the intramolecular nucleophilic attack of the hydroxyl group onto C(2) of the imidazole ring to give trifluoromethylated derivatives of 2,3-dihy...

The voltage gated sodium channel NaV1.8 has been postulated to play a key role in the transmission of pain signals. Core hopping from our previously reported phenylimidazole leads has allowed the identification of a novel series of benzimidazole NaV1.8 blockers. Subsequent optimization allowed t...

A strong relationship between abnormal functions of Aurora kinases and tumorigenesis has been reported for decades. Consequently, Aurora kinases serve as potential targets for anticancer agents. Here, we identified aminobenzothiazole derivatives as novel inhibitors of Aurora B kinase through bio...

A series of 1,3-disubstituted 2-iminobenzimidazolines as well as a number of their tautomeric analogs were synthesized. The synthesized compounds were tested for their cytotoxicity against MDCK cells and for inhibiting activity against influenza virus A/California/07/09 (H1N1)pdm09. Based on the...

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in cancer angiogenesis. In the current study, a series of novel pyrrolo[2,3-d]pyrimidine based-compounds was designed and synthesized as VEGFR-2 inhibitors, in accordance to the structure activity relationship (SAR) stu...

A series of 4-aryl-thieno[1,4]diazepin-2-one were synthesized and evaluated for their antiproliferative activities against the A375P melanoma and U937 hematopoietic cell lines. Several compounds showed very potent antiproliferative activities toward both cell lines and the activities were better...

Extremely simple syntheses of americanol A (1) and isoamericanol A (2) having intriguing neurotrophic properties have been accomplished by HRP catalyzed oxidative coupling of caffeic acid.