An electrode modified with pyridine functionalized gold nanoparticles and three-dimensional graphene was prepared and employed for the voltammetry determination of hexavalent chromium. Graphene oxide was electrochemically reduced on glassy carbon electrode. Gold nanoparticles were electrodeposit...

In 2008, the Mars Phoenix Lander discovered perchlorate at its landing site, and in 2012, the Curiosity rover confirmed the presence of perchlorate on Mars. The research reported here was designed to determine if certain methanogens could grow in the presence of three different perchlorate salt ...

A new double complex, [trans-Cr(N3)2(Me2tn)2]3[Cr(N3)4(Me2tn)]2ClO4 (Me2tn = 2,2-dimethylpropane-1,3-diamine), was prepared, and its structure determined through single-crystal X-ray diffraction at 100 K. The complex crystallizes in the space group C2/c of the monoclinic system with a = 34.255 (...

The penetration and metabolism of 2 - isopropoxyphenyl N-methyl-N-(2-methyl-4-tert - butylphenylsulfenyl)carbamate or sulfenyl-propoxur was examined in the house fly and honeybee. Reduced penetration was found to be a factor contributing to the lower toxicity of sulfenyl-propoxur to the honeybee...

New S-alkylated 5-(2-,3- and 4-methoxyphenyl)-4H-1,2,4-triazole-3-thiols (5a–c, 6a–c) and 5-(2-,3- and 4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols (7a–c, 8a–c, 9a–c) were synthesized by the alkylation of 3-(2-,3- and 4-methoxyphenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thiones (3a–c) ...

The stability of metabolically-generated N-(hydroxymethyl) compounds was investigated using a series of N-methylbenzamides as model substrates. N-(Hydroxymethyl)-benzamide was characterized as a major metabolite of N-methylbenzamide in vitro, and was also identified as a urinary metabolite of N-...

N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]-2-methoxy-5-methyl-benzamide (RHM-1) and N-[2-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)ethyl]-2-methoxy-5-methylbenzamide (RHM-2), two conformationally flexible benzamide analogues, were radiolabeled with tritium (specific activity...

The first enantioselective synthesis of the title neo-trans-clerodanes 3 and 4b from (−)-verbenone 5 has been accomplished using the ene reaction and stereoselective conjugate addition reaction to the enone 13 as the key step.

Using (1S,5S)-(−)-verbenone (8b), readily obtainable from (+)-nopinone (3), as the chiral source, we have established the general method for preparation of three kinds of key intermediates, conjugate enones 9 and 10 for the syntheses of neo-trans-clerodanes and 11 for those of neo-cis-clerodanes...

Expedient synthesis of Co(II) and Ni(II) complexes contriving the general molecular formula [M(L1)2Cl2] have been exemplified, where L1 = 4-((3-ethoxy-2-hydroxy benzylidene)amino)-N-(pyridin-2-yl)benzenesulfonamide. The structural feature of the complexes has been deduced from elemental analysis...

A series of twenty two novel 1-cyclopropyl-6-fluoro-4-oxo-7-(4-substitutedpiperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid analogues were synthesized, characterized (1H NMR, 13C NMR and LCMS) and screened for their in vitro anti-tubercular and antibacterial activity. Many of these compound...

A series of pleuromutilin derivatives bearing piperazine ring have been reported. The in vitro antibacterial activities of the synthetic derivatives against MRSA (ATCC 43300), Staphylococcus aureus (ATCC 29213), Enterococcus faecalis (ATCC 29212), Enterococcus faecium (ATCC35667) and Escherichia...

We synthesized a series of aryl/heteroarylpiperazinyl derivatives of 8-acetyl-7-hydroxy-4-methylcoumarin and evaluated their antidepressant-like activity. We used a fast, microwave-assisted synthesis protocol and 1H, 13C NMR and HRMS spectrometry to confirm the structure of all compounds. We als...

A series of novel 1,4-benzodioxane thiazolidinedione piperazine derivatives targeting FabH were designed and synthesized. The compounds exhibited better inhibitory activity against Gram-negative bacteria by computer-assisted screening, antibacterial activity test and E. coli FabH inhibitory acti...

A convenient method for synthesis of optically active azetidin-2-ones using electrochemical oxidation has been exploited. The method consists of a diastereoselective intramolecular C–C bond forming reaction between active methylene and methyne groups through an electrochemical system in which p...

We have previously reported the novel lead compound 1a as a CCR5 antagonist for treatment of HIV-1 infection. SAR studies on incorporating various acyl groups as a replacement for the 5-oxopyrrolidine-3-carbonyl group of the lead structure resulted in the discovery of N-[3-(4-benzylpiperidin-1-y...

Cinnamate 4-hydroxylase (C4H), a monooxygenase in the plant phenylpropanoid pathway, was assayed for its ability to hydroxylate 29 substrate analogues. Nine of the tested analogues with various aromatic side chains, including 3-coumaric acid, were metabolized by C4H. Seven products from these re...

This study was to investigate the inhibition effects of para-substituted cinnamic acid derivatives (4-chlorocinnamic acid, 4-ethoxycinnamic acid and 4-nitrocinnamic acid) on tyrosinase catalyzing the substrates, with the purpose of elucidating the inhibition mechanism of the tested derivatives o...

The synthesis, characterisation and stereochemical investigations were made for N-nitroso (2) and N-formyl (3) derivatives of t-3-isopropyl-r-2,c-6-bis(4-methoxyphenyl)piperidin-4-one (1) using IR, mass, 1D and 2D NMR spectral studies. The compound 1 prefers to adopt a chair conformation with eq...

The 5-(5-nitro furan-2-ylmethylen), 3-N-(2-methoxy phenyl), 2-N′-(2-methoxyphenyl) imino thiazolidin-4-one compound has been synthesized and fully characterized by FT-IR, 1H and 13C NMR spectroscopy. The crystal structure of the title compound was investigated by X-ray powder diffraction (XRPD)...