Dye sorbing mesoporous titania spheres (TS) are being reported in the present communication. TS were fabricated by polymerizing titanium (IV) isopropoxide under the templating and structure directing influence of sodium alginate-gum acacia composite beads. The TS synthesis was optimized by varyi...

The oxidation of C.I. Reactive Blue 4 (RB4) by photo-Fenton process mediated by ferrioxalate was investigated under artificial and solar irradiation. The RB4 degradation in acidic medium (pH 2.5) was evaluated by the decrease in Total Organic Carbon (TOC) content and color, measured by the decre...

This study investigated the degradation of anthraquinone reactive dye C.I. Reactive Blue 19 (RB-19) with initial concentration of 100 mg L−1 in aqueous solution by ozone oxidation. The results of UV/VIS and FTIR spectra showed that the anthraquinone structures, nitrogen linkages and amino groups...

In an effort to discover novel inhibitors of M. tuberculosis Caseinolytic proteases (ClpP1P2), a combination strategy of virtual high-throughput screening and in vitro assay was employed and a new pyrrole compound, 1-(2-chloro-6-fluorobenzyl)-2, 5-dimethyl-4-((phenethylamino)methyl)-1H-pyrrole-3...

Heme oxygenase-1 (HO-1) is a cytoprotective enzyme and a survival-enhancing factor in a number of cancers. Chronic myeloid leukemia (CML) is a blood cancer caused by pathological kinase activity of the BCR-ABL protein, currently treated with tyrosine kinase inhibitors (TKIs) such as Imatinib (IM...

A series of N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides were synthesized and tested for inhibition of PDGFR and FLT3 autophosphorylation. The novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides, obtained by replacement of the pyrimidine system in Imatinib (1) with an ...

A series of new imidazole based heterocycles (5-(4,5-diphenyl-1H-imidazol-2-yl)furan-2-yl)methyl acetate (Him-dp), (5-(1H-phenanthro[9,10-d]imidazol-2-yl)furan-2-yl)methyl acetate (HIm-pt), (5-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)furan-2-yl)methyl acetate (HIm-phen), 2-(2-nitrophenyl)-4,5-...

The uptake of 14C-labelled noradrenaline and mescaline into a synaptosome-rich preparation from the rat cerebral cortex was studied. Noradrenaline was accumulated by the synaptosome-rich preparation by a temperature-dependent process which was competitively inhibited by desipramine. Mescaline wa...

The psychological, neuropsychological, and neurometabolic effects of the hallucinogenic agent mescaline were investigated in 12 normal men who were volunteers. Mescaline produced an acute psychotic state 312–4 hr after drug intake, as measured by the Brief Psychiatric Rating Scale (BPRS) and Pa...

Microinjections of LSD (0.05 μg), mescaline (0.5 μg) and serotonin (10 μg) into the medial raphe nucleus of rats resulted in a strong potentiation of apomorphine (1 mg/kg i.p.)-induced hypermotility. The potentiating effect of LSD or serotonin was suppressed by simultaneous injections of meth...

To test the possible involvement of serotonin-containing cells of the midbrain in mediating the effects of mescaline on startle responding, electrolytic lesions were made in either the dorsal or median raphe nucleus in rats. Decreases in either striatal or hippocampal tryptophan hydroxylase acti...

The effects of mescaline and d-lysergic acid diethylamide (LSD) applied by microiontophoresis to single raphe neurons were compared to the effects of mescaline and LSD given systemically. LSD inhibited all raphe cells when given intravenously (i.v.) or microiontophoretically. No decrease in acti...

Mescaline sulfate infused iv in anesthetized dogs and cats produced dose-related systemic hypotension and bradycardia, whereas pressor responses were obtained in rats. Mescaline-induced hypotension and bradycardia were not significantly altered by prior atropinization and bilateral vagotomy in d...

1. The modifications of behavior caused in the rat by a chronic oral administration of mescaline have been studied in three experimental situations.2. In the staircase maze mescaline accelerated the spontaneous decay on the conditioned reflex (memory decay) during the period without daily traini...

1.1. The modifications of the rat behaviour caused by a chronic administration of mescaline were studied in two schedules of operant conditioning.2.2. In the “periodic conditioning” test, the schedule of reinforcement was changed from a fixed ratio to a fixed interval schedule. Mescaline (4 mg...

The effect of mescaline sulfate on the binding of aminoacyl-tRNA by brain cortex ribosomes was studied. The poly U-directed binding of 14C-phenylalanyl-tRNA in vitro was moderately inhibited by mescaline. The pretreatment of normal ribosomes with mescaline caused a decrease of their phenylalanyl...

The effects of mescaline and LSD on the flash-evoked cortical potential (FEP) were determined in unrestrained rats with chronically-implanted electrodes. Systemic administration of mescaline or LSD significantly attenuated the primary component of the FEP at three stimulus intensities with the g...

Amberlite IRA-410 anionic exchange resin was evaluated as the binding layer for sampling V(V) by using Diffusive Gradients in Thin Films (DGT). V(V) was determined by inductively coupled plasma mass spectrometry (ICP-MS). Mass vs. time DGT deployments (ionic strength = 0.03 mol L−1 NaNO3, pH = 5...

An efficient Amberlite IRA-400 Cl basic anion exchange resin mediated multicomponent reaction of 2-hydroxybenzaldehydes, 1, 3-diketone and nucleophiles under neat condition afforded a number of fluorescent 4H-chromene derivatives in excellent yield. The structure of the synthesized compounds 4k ...

Aiming to develop promising ALK inhibitors, two series of N2-(2-alkyoxy-6-aliphatic aminopyridin-3-yl)-2,4-diaminepyrimidine derivatives (22a-x and 23a-d) were designed according to scaffold hopping and bioisosterism principles. All compounds were efficiently synthesized by concise reactions and...