Aryl succinic and maleic acid derivatives are potent inhibitors of bovine acetylcholinesterase in vitro. Succinic acid aminophenol derivatives 1b–e and 2b–d act as reversible inhibitors of acetylcholinesterase, while maleic acid aminophenol derivatives 3b–d and 4c–e act as choline subsite-di...

Spencermartinsia viticola is one of the most widespread Botryosphaeriaceae species isolated from grapevines in South Australia and New South Wales vineyards in Australia. A new phytotoxic dipyridine-butane-1,4-diol and a new diacrylic acid derivatives, here named spencertoxin (1) and spencer aci...

A new category of bis- and tris-amides was synthesized using succinic acid, succinic anhydride and maleic anhydride in the Ugi reaction. It provides a simple approach for the synthesis of novel Ugi adducts with additional functional groups such as carboxylic acid, carboxamide and α,β-unsaturat...

The present study was carried out to investigate the physicochemical and structural properties of pectic polysaccharide extracted from Ulmus davidiana (UDP) and to determine the physicochemical, structural, and rheological properties of esterified UDP with succinic acid (ES-UDP). The results ind...

Many cellular and sub-cellular biomarkers associated with mussel (Mytilus edulis) digestive gland and kidney have been characterised. The lysosomal compartment of these tissues have been recognised as being particularly sensitive, exhibiting pollutant induced responses which could be potentially...

A new series of benzofuran substituted chalcone derivatives was synthesized by the base-catalyzed Claisen-Schmidt reaction of the 1-(7-methoxy-1-benzofuran-2-yl) ethanone with different aromatic aldehydes to yield 1-(7-methoxy-1-benzofuran-2-yl) substituted chalcone derivatives 3a-e. We investig...

The reactions of two selected ethers, methyl n-butyl ether (MnBE) and methyl s-butyl ether (MsBE), with three atmospheric oxidants (OH/NO3/Cl) have been investigated at 298 ± 2 K using the relative rate method and gas chromatography-mass spectrometry. The reaction trends of these short chain al...

Bromination of cobalt(III) and chromium(III) 2,4-pentanedionates has been thoroughly investigated by GC and HPLC. GC was found to be unsuitable for analysis of the cobalt complexes and HPLC was recommended for monitoring electrophilic substitutions of metal β-diketonates, especially chelates wh...

Cross-linked polymer-bound lithium dialkylamides were employed in crossed aldol reaction of various carbonyl compounds with aldehydes to afford the corresponding β-hydroxycarbonyl compounds. The introduction of spacer chains to the polymer-bound lithium dialkylamide between the base moiety and ...

Methomyl (MET) is a carbamate insecticide that has been widely used to protect the crop against insects as an alternative for organophosphorus insecticide. Thus the present study aims to evaluate the potential toxic effects of MET on the developmental stages of Bufo arabicus. Tadpoles were class...

Methomyl (S-methyl-1-N-[(methylcarbamoyl)oxy]thioacetimidate) is a carbamate pesticide. It has been noted that in some cases of methomyl poisoning, methomyl is either not detected or detected only in low concentrations in the blood of the victims. However, in such cases, methomyl is detected at ...

Oil loss is a common problem in high oil volume fraction fat-structured foods, where trans fatty acids are absent and saturated fatty acids minimized. Usually a stabilizer “fat”, rich in behenic and stearic acids is added to these products. This stabilizer significantly reduces oil migration a...

2-Fluoro-3-phenyl-allyltrimethylsilane, prepared from β-fluorinated allylic acetate via a π-allylpalladium intermediate, reacted with various aldehydes and acetals in the presence of TiCl4 to afford the corresponding homoallyl alcohols and homoallyl ethers, respectively, in good to moderate yi...

Prion diseases are fatal neurodegenerative disorders of the central nervous system characterized by the accumulation of a protease resistant form (PrPSc) of the cellular prion protein (PrPC) in the brain. Two types of cellular prion (PrPC) compounds have been identified that appear to affect pri...

A new series of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamide hybrids 8a-l have been designed and synthesized using peptide coupling agents with substituted N-phenyl piperazines and piperidines with good to excellent yields. The synthesized compounds were evaluated for their in vit...

The reverse transcriptase (RT) of the human immunodeficiency virus type-1 (HIV-1) is still a prime target for drug development due to the continuing need to block drug-resistant RT mutants by new inhibitors. We have previously identified 1-(4-chloro-2,5-dimethoxyphenyl)-3-(3-propoxypropyl)thiour...

The triterpene esters ᴪ taraxasterol-3-O-myristate (1) and arnidiol-3-O-myristate (2) were tested for their ability to protect epithelial intestinal barrier in an in vitro model. Their effects on ROS production and on trans-epithelial resistance were investigated on CaCo-2 cell monolayers both i...

In this paper, we describe the synthesis of (+)-(1R∗,2R∗)-2-[(1S∗)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarboxylic acid (+)-16a, a compound, that is, fluorinated at the alpha position of the carboxylic acid in the cyclopropane ring of a group II mGluRs antagonist, 1 (...

4-(1,2,3,4,10,10a-Hexahydro-3,3-dimethyl-1-oxophenazin-10a-yl)-2,6-di-tert-butylphenol [10a-(3,5-di-tert-butyl-4-hydroxyphenyl)-3,3-dimethyl-1,2,3,4,10,10a-hexahydro-1H-phenazin-1-one] was obtained by the condensation of 3-(2-aminophenylamino)-5,5-dimethyl- 2-cyclohexen-1-one and 2,6-di-tert-but...

Liquid phase oxidation of olefins with nitrous oxide is a promising synthetic route to ketones. The effect of cis/trans isomerism on the reactivity of olefins towards N2O and on the reaction mechanism was studied for the first time using 3-heptene oxidation as an example. Our experimental study ...