Poly(1-dodecene-co-para-methylstyrene) copolymers with a broad composition range were prepared by an MgCl2 supported TiCl4 catalyst. The effects of temperature and hydrogen on catalyst activity were investigated. It was found that catalyst activity reached a maximum at around 60 °C, and then de...

A new nanoporous N-heterocyclic carbene-based cross-linked aromatic polymer (NHC-CAP-1) incorporated with highly nucleophilic bromide anions and with a large surface area was synthesized by a simple Friedel-Crafts reaction of imidazolium salt, triphenylbenzene, and formaldehyde dimethyl acetal. ...

The cis, square planar NiII complexes NiX2[d(py)pe], where d(py)pe is the 2-pyridyl-diphosphine ligand py2P(CH2)2Ppy2, and X = Cl (1a), Br (1b), I (1c), NCS, and NO3, and the corresponding d(py)pcp complexes, where d(py)pcp is with a cyclopentane ring bridge, are synthesized via use of the NiX2...

Many synthetic glucocorticoids from medical applications occur in the aquatic environment. Whether they pose a risk for fish health is poorly known. Here we investigate effects of glucocorticoids fluticasone propionate (FLU) and triamcinolone acetonide (TRI) as single steroids and as ternary mix...

Cholesteryl-containing ionic liquid crystals (ILCs) 1-cholesteryloxycarbonylmethyl(propyl)-3-methyl(butyl)imidazolium chlorides ([Ca-Me-Im]Cl, [Ca-Bu-Im]Cl, [Cb-Me-Im]Cl and [Cb-Bu-Im]Cl) and corresponding imidazolium tetrachloroaluminates ([Ca-Me-Im]AlCl4, [Ca-Bu-Im]AlCl4, [Cb-Me-Im]AlCl4 and [...

Bifunctional silanes ClCH2SiF3 and ClCH2SiF2Me react with N-trimethylsilyl-N-methylacetamide and its tautomer О-trimethylsilyl-N-methylacetimidate as ambident substrates to give the products of trans-silylation N-{[chloro(difluoro)silyl]methyl}-N-methylacetamide and N-{[chloro(fluoro)methylsily...

3-Chloro-4-(chloromethyl)5-hydroxy-2(5H)-furanone (CMCF), a chlorine disinfection by-product in drinking water, was mutagenic in the Salmonella/his (Ames) assay for both base-pair substitution strains (TA1535, TA100 TA102) and frameshift strains (TA97, TA98) with the highest mutagenic response o...

Three reactions occurring on the C3H4Cl potential energy surface (PES) were studied computationally using quantum chemistry and master equation/RRKM: CH2Cl + C2H2 → Products (1), CH2CHCHCl → Products (2), and CH2ClCHCH → Products (3). The results indicate low importance of the 1,3-Cl shift ch...

Lipase B from Candida antarctica efficiently catalysed the kinetic resolution of ethyl (±)-4-chloro-3-hydroxybutanoate through an ammonolysis reaction. Using this methodology, both enantiomers of 4-chloro-3-hydroxybutanamide were prepared and converted into pyrrolidin-3-ol and 5-(chloromethyl)-...

SummaryADP-ribosylation refers to the addition of one or more ADP-ribose groups onto proteins. The attached ADP-ribose monomers or polymers, commonly known as poly(ADP-ribose) (PAR), modulate the activities of the modified substrates or their binding affinities to other proteins. However, progre...

A simple, fast and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Montelukast Sodium (MONT) and Fexofenadine hydrochloride (FEXO). The chromatographic separation was achieved on X-bridge C18 column (250 mm × 4.6 mm, ...

The design of a series of thromboxane receptor antagonists based on 3-(2-[{(4-chlorophenyl)sulfonyl}amino]ethyl)benzenepropanoic acid (1) is described. Addition of an arylmethyl group at the 5-position of 1 gave exceptionally potent agents in vitro and in vivo, with 13a (UK-147,535) giving compl...

The screening tests of N-hydroxybenzamides for their HDAC-inhibitory activities led to the discovery of the promising compounds with a 2-naphthylcarbonyl group and with a 1,4-biphenylcarbonyl group. These compounds were further modified to optimize their physico-chemical profile. As a result, th...

A highly diastereoselective synthesis of trichoverrol B (1) is described. Critical to the success of this work is the development of a method for esterification of (Z,E)-dienoic acid derivatives without olefin isomerization.

We have developed an easy and practical method for the synthesis of α,β-unsaturated oximes and nitriles from readily available propargylic alcohols with hydroxylamine hydrochloride (NH2OH·HCl) under metal-free conditions. By using or not using p-toluenesulfonyl chloride (p-TsCl) as the dehydr...

Heterogeneous acid catalysts were obtained based on the functionalization of reduced graphene oxide. The synthesis involves i) the obtaining of graphene oxide by the modified Hummers method ii) the reduction of graphene oxide by three different routes, through the use of hydrazine dihydrochlorid...

In an attempt to find a new class of antimicrobial agents, a series of thiazole, thiophene, pyrazole and other related products containing benzothiazole moiety were prepared via the reaction of N-(benzothiazol-2-yl)-2-cyanoacetamide (1) with appropriate chemical reagents. These compounds were sc...

A new complex trans-anti-[Cr(Me2tn)2(N3)2]ClO4·2H2O, where Me2tn = 2,2-dimethyl-1,3-propanediamine was synthesized and characterized, and its molecular structure was established by single-crystal X-ray diffraction at 95 K. The complex crystallized in the space group C2/c of the monoclinic syste...

The structure of [CrF2([15]aneN4)]ClO4·H2O ([15]aneN4 = 1,4,8,12-tetraazacyclopentadecane) has been determined by a single-crystal X-ray diffraction study at 173 K. The complex crystallizes in the space group P1− of the triclinic system with two mononuclear formula units in a cell of dimensions...

Inorganic oxidizing energetic salts including nitrates, chlorates and perchlorates are widely used in the manufacture of not only licit pyrotechnic compositions, but also illicit homemade explosive mixtures. Their identification in forensic laboratories is usually accomplished by either capillar...