Several 1-aryloxy-2-substituted aminomethyltetrahydronaphthalenes (7–21) as conformationally rigid analogues of fluoxetine were synthesized and evaluated for their anorexigenic and antidepressant activities. For SAR studies the related acyclic analogues (22–27) were also prepared. Out of the 2...

Transmembrane protein 16A (TMEM16A) channels are recently discovered membrane proteins that functions as a calcium activated chloride channel (CaCC). CaCCs are major regulators of various physiological processes, such as sensory transduction, epithelial secretion, smooth muscle contraction and o...

The hydrolysis of cellulose catalyzed by sulfonated poly(styrene-co-divinylbenzene) (SPS–DVB) was carried out in the ionic liquid 1-n-butyl-3-methylimidazolium bromide (BMIMBr), in which the reaction medium BMIMBr and sulfate polymer catalyst can be recovered. The influence of the amount of cat...

Octreotide, a disulfide-cyclized eight amino acids long analogue of somatostatin, has been used to treat the symptoms associated with metastatic carcinoid tumors (flushing and diarrhea), and vasoactive intestinal peptide secreting adenomas (watery diarrhea). As composed by D-amino acids, C-termi...

The synthesis of poly(styrene-co-divinylbenzene) microparticles by the suspension polymerization technique requires the use of some protective agents to reduce the coalescence/agglomeration of the microparticles during the polymerization process. Since the effect of each protective agent may var...

A simple, rapid, selective and sensitive monitoring method for the simultaneous determination of the widely-prescribed antidepressants agomelatine, bupropion, citalopram, fluoxetine, mirtazapine, paroxetine, trazodone in just a human blood drop is here developed and validated. This methodology i...

Molecular dynamics (MD) and Grand Canonical Monte Carlo (GCMC) simulation were employed to investigate the relationship between the crosslinking degree and structure, hydrophobic behavior for poly (styrene-co-divinylbenzene) （P(S-DVB)）copolymer. The structure properties of P(S-DVB) with differ...

With the extensive applications of gold nanoparticles (AuNPs) and the confirmation of their toxicity on human health and environment, it was urgent to remove AuNPs from environment. The hierarchically porous poly(ethylenimine) modified poly(styrene-co-divinylbenzene) microsphere (PEI-PS-DVB) was...

Catalyst performance is highly relevant to its mass transport performance. In the present study, seven styrene-co-divinylbenzene polymer samples were synthesized by varying the amounts of crosslinker and porogen, so as to elucidate mass transport mechanism in poly (styrene-co-divinylbenzene) mic...

The way of application is an important issue in thermal energy storage (TES) materials. Phase change materials are encapsulated to prevent leakage and to get application advantage. At the last decade, microencapsulated phase change materials (MEPCMs) are produced with functional outer surfaces. ...

Reaction of 4′-chloro-2,2′:6′,2″-terpyridine with 3-phenyl-n-propanol or n-propanol in the presence of excess KOH in dmso, respectively, yields 4′-(3-phenylpropoxy)-2,2′:6′,2″-terpyridine (L2) and 4′-(3-propoxy)-2,2′:6′,2″-terpyridine (L3). The following complexes of these two ligand...

A simple methodology to design metal-free porphyrin (meso-tetra-(1-naphthyl)porphyrin) and their corresponding transition metal complexes (Zn(II), Cu(II), Ni(II), Co(III) and Mn(III)) is described. These porphyrins were fully characterized by elemental analysis, HRMS-ESI, UV–vis absorption, ste...

Nonlinear optical (NLO) properties of N-substituted p-nitroaniline molecule, N-[(Naphthalen-5-yl)methyl]-4 nitrobenzamine has been calculated theoretically. The theoretical calculations were performed at B3LYP/6-31G(d,p) level. It exhibits large first static hyperpolarizability. The optical resp...

Many known 5-HT7 ligands contain either a serotonin-like or an arylpiperazine structure that, in published SAR studies, are generally supposed to bind the same receptor pocket. Conversely, we explored the hypothesis that two such moieties can co-exist in the same ligand, binding to different poc...

The effects of a solvent on the position of the long-wavelength electronic absorption band of N-[4-(9-acridinylamino)-3-methoxyphenyl]methanesulfonamide hydrochloride [m-AMSA.HCl], an antitumor drug, were investigated. To assess the nature of molecular interactions of protonated m-AMSA (1) with ...

Linear amphiphilic diblock copolymers of polylactide (PLA) and poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) were synthesized by atom transfer radical polymerization (ATRP) of DMAEMA followed by ring-opening polymerization (ROP) of LLA using the bifunctional initiator, 2′-hydroxyethyl 2-bro...

A new type of stimuli-responsive organic/inorganic nanocomposite hydrogels and cryogels was prepared by introducing Laponite into poly(N,N-dimethylaminoethyl methacrylate-co-2-acrylamido-2-methyl-propanosulfonic acid) copolymeric network. The effect of Laponite concentration on the equilibrium w...

The biomass kraft lignin was modified into lignin-based macroinitiators (LnMI) through esterification of the alcohol and phenol functional groups on lignin backbone with 2-bromo-isobutyric bromide under mild condition. Then a series of cationic amphiphilic lignin-based graft copolymers were synt...

Living poly[(2-dimethylamino)ethyl methacrylate] (PDMAEMA) has been synthesized by Atom Transfer Radical Polymerization (ATRP) of (2-dimethylamino)ethyl methacrylate in bulk at 30 °C using CuCl/N,N,N′,N″,N″-pentamethyldiethylenetriamine catalyst. Addition of catalytic amount of tricaprylylme...

In this work, CdSe quantum dots (CdSe QDs) were successfully synthesized and embedded in a biopolymer based on poly((2-dimethylaminoethyl) methacrylate) grafted onto kappa-Carrageenan (κC) via a facile process. The synthesized samples were studied by transmission electron microscopy (TEM) and i...