A new series of fluorescent chemosensors (7a-7f) based on a core skeleton of 2-(benzylideneamino)-4,5,6,7-tetrachloro-3′,6′-dihydroxyspiro-[isoindoline-1,9′-xanthen]-3-one was synthesized and characterized by FT-IR, NMR and mass spectrometric techniques. The sensitivity and selectivity of pro...

This work present a new approach for the detection of relatively new herbicide pethoxamid (POA), a first electrochemical behavior and determination based on its oxidation on boron-doped diamond electrode in Britton-Robinson buffer solution at pH 4. Square wave voltammetric technique was used for...

Soil is a non-renewable resource, and its degradation compromises human health, natural ecosystems, and even the climate. The application of organic amendments and herbicides is commonplace in agriculture, and their impact on soil fertility needs to be evaluated. Therefore, the objective was to ...

The development of 8-(2,3,3a,4,5,6-hexahydro-1H-phenalen1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones 3 starting from (RS)-8-acenaphten-1-yl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 1 is reported. The synthesis and the binding affinities at human OFQ and opioid (μ, κ, δ) receptors of t...

Tetrahydrobiopterin (BH4) is a crucial cofactor for nitric oxide synthase, acylglycerol mono-oxygenase and aromatic amino acids hydroxylases. Its significant function for redox pathways in vivo attracted much attention for long. However, because of the oxidizable and substoichiometric nature, an...

Quantitative analysis of glycans is an emerging field in glycomic research. Herein we present a rapid and effective dual-labeling strategy, in the combination of isotopic derivatization of N-glycosylamine-based glycans by d0/d5-benzoyl chloride and methylamidation of sialic acids, to relatively ...

A 6-month calf was treated with 1 mg kg−1 wet weight of 17-β-boldenone undecanoate and urine and faeces were collected for a period of 30 days after the treatment to follow the depletion of the different substances related to boldenone. Hair was collected for just a few days. Multiresidue extra...

One potential explanation for the presence of β-boldenone in calf urine is contamination of the sample with feces containing β-boldenone. It has been demonstrated that after oral and intramuscular administration of β-boldenone esters, several metabolites are formed and excreted in urine. One ...

Boldenone is an androgenic steroid that improves the growth and food conversion in food producing animals. In most countries worldwide, this anabolic steroid is forbidden for meat production. Until recently, the control of its illegal use was based either on 17β-boldenone or 17α-boldenone (its...

Collaborative microbial communities are ubiquitous in nature and exhibit appealing functions for enhanced production of natural products, which provides new possibility for biotechnology development. In this study, we bridged Mycobacterium neoaurum with Pichia pastoris to establish a step-wise b...

A new potent Pseudomonas aeruginosa isolate capable for biotransformation of corn oil phytosterol (PS) to 4-androstene-3, 17-dione (AD), testosterone (T) and boldenone (BOL) was identified by phenotypic analysis and 16S rRNA gene sequencing. Sequential statistical strategy was used to optimize t...

Boldenone is one of the most frequently detected anabolic androgenic steroids in doping control analysis. Boldenone misuse is commonly detected by the identification of the active drug and its main metabolite, 5β-androst-1-en-17β-ol-3-one (BM1), by gas chromatography–mass spectrometry (GC–MS...

Boldenone (BOLD), one of androgenic anabolic steroids (AAS), although banned in humans, is still available illegally. AAS abuse has previously been associated with various cardiovascular adverse events including acute myocardial infarction, arrhythmia, and sudden death. In this study, the concen...

Boldenone is an anabolic-androgenic steroid that is prohibited in equine sports. Urine from the uncastrated male horse contains boldenone that is thought to be of endogenous origin and thus a threshold (‘cut-off’) concentration has been adopted internationally for free and conjugated boldenone...

New mesoionic compounds (2H, 3H-thiazolo[3,2-c]oxazol-7-ones) (β) or ketenes ((3-acyl-1,3-thiazolidin-2-ylidene)methanone) (β′) were generated from N-acetyl and N-benzoyl-thiazolidine-2-carboxylic acids (7a,b) using different methods, and their reactivity towards N-(phenylmethylene)benzenesul...

The applicability of 4-methylumbelliferyl-p-guanidinobenzoate hydrochloride (MUGB) as active-site titrant for tissue-type plasminogen activator (t-PA) was studied in comparison to urokinase. Although t-PA was capable of cleaving MUGB, active-site titration of t-PA (one-chain form as well as two-...

The Today® Contraceptive Sponge was evaluated as a vehicle for the delivery of aryl 4-guanidinobenzoates (AGs) which are highly active sperm acrosin inhibitors. Studies in animals have shown that several AGs are more potent vaginal contraceptives and less irritating to the vagina than nonoxynol-...

Methylthio-substituted allenylmethylsilane, a kind of allylsilane, undergoes only [2 + 2] cycloaddition reaction with alkenes mediated by a Lewis acid to afford the corresponding methylenecyclobutanes which are readily converted to di-exo-methylenecyclobutanes by the sequential oxidation-1,2-eli...

In the course of a study on 1H-imidazol-1-amine derivatives as antifungal agents, we found that N-[(1,1′-biphenyl)-4-ylmethyl]-N-[(2,4-dichlorophenyl)methyl]-1H-imidazol-1-amine (1a) exhibited promising activities. In order to explore more in detail the structure–activity relationship of this ...

Vapour–liquid equilibrium data in the three binary 2,2,4-trimethylpentane + 2-methyl-1-propanol, 2-methyl-1-propanol + 4-methyl-2-pentanone, 2,2,4-trimethylpentane + 4-methyl-2-pentanone systems, and in the ternary 2,2,4-trimethylpentane + 2-methyl-1-propanol + 4-methyl-2-pentanone system are r...