Vapour–liquid equilibrium data in the three binary tert-butyl methyl ether + 3,3-dimethyl-2-butanone, 3,3-dimethyl-2-butanone + 2,2-dimethyl-1-propanol, tert-butyl methyl ether + 2,2-dimethyl-1-propanol systems, and in the ternary tert-butyl methyl ether + 3,3-dimethyl-2-butanone + 2,2-dimethyl...

Five new lanthanide coordination polymers, [Ln2(HPA)6(phen)2·solvent] (Ln = Eu, solvent = 4H2O for 1, Ln = Tb, solvent = 2CH3OH for 2, Ln = Pr, solvent = 2H2O for 3, Ln = Nd for 4 and Ln = Er for 5), (HHPA = 3-(4-Hydroxyphenyl)propanoic acid and phen = 1,10-phenanthroline), were successfully sy...

We report a 2-(4-amino-2-hydroxyphenyl)benzothiazole based Schiff-base, a potential excited state intramolecular proton transfer (ESIPT) chromophore, exhibits aggregation induced emission enhancement (AIEE) in the solvent mixture of DMSO:HB. The presence of Cu2+ ions promote imine hydrolysis res...

4-Hydroxyphenyl substituted thiopyrimidine derivatives have been synthesized with the starting compound 5-benzoyl-6-phenyl-4-(4-hydroxyphenyl)-1,2,3,4-tetrahydro-2-thioxopyrimidine (1). The compounds optimized geometrically with DFT in Gaussian at the B3LYP/6-31G (d, p) level in order to obtain ...

The anti-diabetic activity of the methanolic extract of Uvaria afzelii (Annonaceae) root bark was investigated in normoglycaemic, glucose and alloxan-induced diabetic rats using glibenclamide (5 mg/kg) and normal saline as positive and negative controls respectively. The acute oral toxicity test...

To determine of irradiation effect on 4-hydroxyphenyl-acetic acid polycrystalline, electron paramagnetic resonance (EPR) measurements were carried out. Two samples were used, which were given dose of 22.8 and 49 kGy by gamma rays using 60Co-source. EPR signals were not observed from irradiated s...

Two new compounds N′-[bis(methylsulfanyl) methylene]-2-hydroxybenzohydrazide {Hbmshb (1)} and N′-(4-methoxy benzoyl)-hydrazinecarbodithioic acid ethyl ester {H2mbhce (2)} have been synthesized and characterized with the aid of elemental analyses, IR, NMR and single crystal X-ray diffraction da...

Synthesis of (±)-4′-ethynyl-5′,5′-difluoro-2′,3′-dehydro-3′-deoxy-carbocyclic-thymidine (8) was carried out. The difluoromethylylidene group of 8 was constructed by the electrophilic fluorination to the cyclopentenone 11 by using Selectfluor®. Introduction of thymine base was investigated...

Flavonoids are a class of compounds that exist in nature with the structure of 2-phenyl-chromone. In Chinese traditional medicine, herbal drugs containing flavonoids are widely used for the treatment of inflammation, cardiovascular disease, tumor and so on. In this study, we investigated the ant...

Dihydropyrimidine derivatives have great potential in the treatment of various kinds of cancers. The main problem associated with these medicines is the poor solubility of these drugs in an aqueous media. Hence, in the current research work, the solubility of dihydropyrimidine derivative i.e. 4-...

The epoxidation and the OsO4-catalyzed bishydroxylation of cyclic tert-butyl allyl peroxides 1 – 6 have been investigated. The epoxidation of 1, 2, 3, 5 carried out with four different oxidants proceeded mainly with high anti-selectivity referred to the tBuOO group leading to the epoxides 12–1...

The tetracarbonyl complexes cis-[Mo(CO)4{2-[3(5)-pyrazolyl]pyridine}] (1) and cis-[Mo(CO)4{ethyl[3-(2-pyridyl)-1-pyrazolyl]acetate}] (2) were obtained in excellent yields by microwave-assisted heating of a mixture of Mo(CO)6 and the organic ligand in toluene at 110 °C for 30 min. Complexes 1 an...

In this study, new Mannich bases, 2-(4-hydroxy-3-methoxy-5-((substitutedpiperazin-1-yl)methyl)benzylidene)-2,3-dihydro-1H-inden-1-one (1, 2, 4, 5, 8), 2-(3-((substituted)piperazin-1-yl)methyl)-4-hydroxy-5-methoxybenzylidene)-2,3-dihydro-1H-inden-1-one (3, 6, 7) were synthesized with the reaction...

5-(2-(4-Methoxyphenyl)ethyl)-2-amino-3-methylcarboxylate thiophene (TR560) is the prototype drug of a recently discovered novel class of tumor-selective compounds that preferentially inhibit the proliferation of specific tumor cell types (e.g. leukemia/lymphoma). Here, we further increased tumor...

A general, highly effective two-step approach for direct synthesis of (1H-tetrazol-5-yl)furoxan ammonium salts with various functional substituents based on initial effective synthesis of cyanofuroxans by dehydration of furoxancarboxylic acid amides by the action of (CF3CO)2O/Py followed by [3+2...

With multidrug resistant bacteria on the rise, novel antibiotics are becoming highly sought after. In 2008, eleven compounds were identified by high throughput screening as inhibitors of BasE, a key enzyme of the non-ribosomal peptide synthetase pathway found in Acinetobacter baumannii. Herein, ...

o-Phthalic anhydride/Zn(OTf)2 co-catalyzed Beckmann rearrangement was developed, producing the corresponding amide in up to 99% yield with acid-sensitive functionalities tolerated well, and the scale of the reaction could be enlarged to 77 mmol and the excellent yield was maintained. A successiv...

The reaction between [CuCl2·2H2O] and N,N′-bidentate N-(pyridin-2-ylmethyl)amines (Ln = LA–LE) in methanol yielded new Cu(II) complexes; namely mononuclear [LACuCl2] and dinuclear [LnCu(μ-Cl)Cl]2 (Ln = LB–LE) complexes, respectively. Monomeric [LACuCl2] showed a distorted square planar geom...

In this paper, two di-substituted triazine-based ligands, 6-chloro-N,N,N′N′-tetrakis-pyridin-2-ylmethyl-[1,3,5]triazine-2,4-diamine (L1), and 6-chloro-N,N′-bis-pyridin-2-ylmethyl-N,N′-bis-thiophen-2-ylmethyl-[1,3,5]triazine-2,4-diamine (L2), have been prepared. Reaction of CuCl2·2H2O and Cu...

A new Schiff base, (E)-3,5-dimethoxy-2-((6-methoxybenzo[d]thiazol-2-ylimino)methyl)- phenol, was prepared from the reaction of 2-amino-6-methoxybenzothiazole and 2-hydroxy-4,6-dimethoxybenzaldehyde and characterized with elemental analysis, FTIR, UV-VIS, NMR and single crystal X-ray diffraction ...