Four different syntheses of the potent and selective muscarinic antagonist cyclohexy1(4- fluorophenyl)(3-piperidinopropyl)silanol (p-Fluoro-hexahydro-sila-difenidol, p-F-HHSiD (2b); isolated as hydrochloride 2b-HCI) are descirbed (starting materials: (CH3O)3SiCH2CH2CH2CI and Si(OCH3)4). In addit...

Cation CpFeC5H4–C+=CH2 was obtained by protonation of FcCCH with Nafion superacid in DMF or scCO2 and characterized by NMR spectroscopy. The protonation in the presence of SMe2 or PPh3 affords new onium derivatives, which were isolated as the tetrafluoroborate salts.

The electron-pair density distributions of a series of 25 Fischer carbene complexes of the type (CO)5CrC(X)R (X=H, OH, OCH3, NH2, NHCH3 and R=H, CH3, CHCH2, Ph, CCH) are analyzed using the Atoms in Molecules theory. Localization and delocalization indices are used to characterize the elect...

A study of the temperature dependence of the gas-phase reactions of OH radicals and Cl atoms with a series of hydrofluroolefins: 2-fluoropropene (CH3CFCH2), hexafluoroisobutylene ((CF3)2CCH2) and (E/Z)-1,2,3,3,3-pentafluoropropene ((E/Z)-CF3CFCHF) has been performed. The relative-rate technique ...

Three cationic Schiff surfactants namely; N,N-dimethyl-4-(((1-methyl-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino)methyl)-N-octylbenzenaminium bromide (APS-8); N,N-dimethyl-4-(((1-methyl-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino)methyl)-N-dodecyl benzenaminium bromide (APS-12) and N,N-dimethyl-4-...

We have synthesized (E)-1-(2, 6-bis (4-methoxyphenyl)-3, 3-dimethylpiperidine-4-ylidene)-2-(3-(3, 5-dimethyl-1H-pyrazol-1-yl) pyrazin-2-yl) hydrazine (PM6). It was characterized using FT-IR, FT-Raman, 1H NMR, 13C NMR techniques. To interpret the experimental data, ab initio computations of the v...

1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting ant...

A novel series of 3-(4, 5-dihydro-1-phenyl-5-substituted phenyl-1H-pyrazol-3-yl)-2H-chromen-2-one derivatives were synthesized. In the first step salicylaldehyde was reacted with ethylacetoacetate at room temperature by stirring which gives compound (I). Compound (I) when refluxed with substitut...

The effective synthesis of pharmacologically oriented heterocyclic ensembles, [2-(1H-pyrazol-1-yl)thiazol-4-yl]furoxans, comprising furoxan moiety as NO-donor and pharmacophoric pyrazolylthiazole fragment is based on the condensation of (2-hydrazinylthiazol-4-yl)furoxan hydrobromides with linear...

Novel tertiary butylisocyanide complexes of manganese(II) with unusual stoichiometry, MnX2(CNBut) (X = Cl, Br, I, NCS), have been prepared and characterised by magnetic susceptibility measurements and infrared and electron spin resonance spectroscopy. For X = Cl, Br, I the complexes have been as...

Novel dinuclear palladium complexes having two isocyanide ligands were synthesized by using a binucleating ligand, N,N′-bis[2-(diphenylphsphino)phenyl]formamidinate (dpfam). The structure of [Pd2(μ-dpfam)(tert-BuNC)2]Cl was confirmed by X-ray analysis, showing that the Pd–Pd bond length of 2....

Tert-butylisocyanide inserts into the carbon-sulfur bond of α-cyano sulfides 2-6 to give thioimidates 10-14. The thioimidates can also be obtained via the chlorine substitution of the tert-butylimino chloro sulfides 27-28, which is a more general method. These thioimidates rearrange to E and Z ...

Dihydrogen reacts slowly with [N3N]WH ([N3N]3−[(Me3SiNCH2CH2)3N]3−) in benzene at 22°C to form white, crystalline, diamagnetic [N3N]WH3 quantitatively. [N3N]WH in C6D6 reacts with ethylene to produced [N3N]WCMe quantitatively, while the reaction between [N3N]WH and propylene at 45°C for 24...

We have previously reported a molecular and cytogenetic characterization of three different 5S rDNA clusters in the sea urchin Paracentrotus lividus; this study, performed at DNA level only, lends itself as starting point to verify that these clusters could contain transcribed genes, then, to de...

The structural evolution, electronic and magnetic properties of the high-pressure nonpolar orthorhombic phase (orthorhombic, space group Pnma) and the LiNbO3-type (rhombohedral, space group R3c) InFeO3 have been explored via first-principles calculations. Furthermore, the ferroelectric propertie...

BackgroundMedication reconciliation (medrec) is a mandated patient safety strategy by national, including Australian, accreditation bodies. Yet there are no validated performance measures.

One cluster of 5S rDNA per haploid genome is the most common pattern among Heteroptera. However, in Chariesterus armatus, highly scattered signals were noticed. We isolated and characterized the entire 5S rDNA unit of C. armatus aiming to a deeper knowledge of molecular organization of the 5S rD...

This article examines the experience in 5S methodology implementation in order to optimize the work and safety of the university engineering laboratories, in such a way that the results obtained can be extended to other, similar centers. The research project developed has created an organization...

The 5S (sort, set, shine, standardize and sustain) lean tool has been known to improve system performance. In the current study, the short run dynamic implications of the sorting aspect of 5S is investigated using system dynamics. A system dynamics model is developed for a manufacturing case stu...

To reveal the evolutionary relationship of three mitten crabs (Eriocheir sinensis, E. hepuensis, and E. japonica), complete mitogenomes and nuclear 5S rDNA sequences were analyzed. Sequencing revealed that the mitogenomes analyzed shared conserved organization of the coding and non-coding region...