Studies concentrating on non-covalent interactions between the organic base of 2,6-diaminopyridine, and carboxylic acids have led to an increased understanding of the role 2,6-diaminopyridine in binding with carboxylic acid derivatives. Here anhydrous and hydrated multi-component organic acid-ba...

A neutron powder-diffraction analysis of uranium tribromide has been carried out with the profile-fitting technique and has confirmed that UBr3 is of the UCl3 structure type. The final value of R = ∑i(|Ioi − Ici|)/∑iIoi was 0.10, where Ioi is one of the 395 background-corrected measured intens...

The thermal decomposition of uranium pentabromide has been studied; and the free energy and standard heat of formation of this compound have been measured. The standard heat of formation of UBr5 was found to be ΔH298f = −197·5 ± 1·3 kcal/mole. Only at temperatures below 80°C was an apparent...

Analysis of the neutron powder pattern of uranium pentabromide shows its structure to be of the triclinic β-UCl5 type, and not the α-PaBr5 type as proposed by earlier workers. Refinement by the profile fitting technique shows it to consist of U2Br10 dimers, the anions being in a simple hexagon...

We present an exploration of the chemiluminescence from reactions of benzylpiperazines and phenylpiperazines with tris(2,2′-bipyridine)ruthenium(III). The selectivity of the reagent towards these compounds was found to be highly dependent upon the pH of the solution, and the relative emission i...

This study presents the synthesis and biological evaluation of a new series of arylalkyl/arylalkylsulfonyl piperazine and piperidine-based derivatives as sigma receptor ligands. It was found that a number of halogen substituted sulfonamides display relatively high and low affinities to σ1 and σ...

Recently numerous non-fluoroquinolone-based bacterial type II topoisomerase inhibitors from both the GyrA and GyrB classes have been reported as antibacterial agents. Inhibitors of the GyrA class include aminopiperidine-based novel bacterial type II topoisomerase inhibitors (NBTIs). However, inh...

A series of galactosyl naphthalimide-piperazine derivatives have been synthesized as intracellular pH and lysosome-targeting imaging probes for live human hepatoma cells. The probes show good sensitivity in both aqueous buffer and intracellular environments. Incorporation of the galactose moiety...

Six novel push–pull azo disperse dyes were synthesized via classical azo coupling reaction using 2-amino-thiazolyl derivatives as the diazo components and 1-(4-bromobenzyl)-4-phenylpiperazine as a key coupling intermediate. The structures of the dyes and synthesized intermediate were confirmed ...

In this work we offer linear regression models on a set of aryl-piperazine derivatives that are obtained by exploring a pool containing 1497 Dragon molecular descriptors, in order to establish the best relationships linking the molecular structure characteristics to their exhibited potencies aga...

Twelve derivatives of artemisinin-piperazine-dithiocarbamate have been synthesised, and some of them showing good in vitro cytotoxic activity. Compound 3g exhibits the best inhibitory activity against SMMC-7721 cell lines with an IC50 of 0.0025 ± 0.04 μM for 72 h, but the toxicity was lower ag...

A general and practical Lewis acids catalyzed synthesis of aryl formates has been established. With catalytic amount of cheap metal as the catalyst, good to excellent yields of aryl formates can be isolated with good functional group tolerance. Formic acid has been applied as the formyl source a...

Two new adamantylnaphthalene derivatives 1-(2-hydroxy-2-adamantyl)-4-methoxynaphthalene (5) and 1-(2-hydroxy-2-adamantyl)-5-methoxynaphthalene (6) were synthesized and characterized by NMR spectroscopy. In addition, 5 was characterized by single crystal X-ray structural analysis and DFT calculat...

This paper reports a synthetic and NMR spectroscopic studies of two new series of 4-fluorinated 1,3,5-substituted 1H-pyrazoles. Firstly, an efficient synthesis of new series of 3-aryl-4-(di)fluoromethyl-1H-1-phenylpyrazoles, where [aryl = Ph, 4-NO2C6H4, 4-CH3OC6H4] is described, from fluorinatio...

Two new classes of antitubercular agents, namely 5-alkylsulfanyl-1-(3,5-dinitrophenyl)-1H-tetrazoles and 2-alkylsulfanyl-5-(3,5-dinitrophenyl)-1,3,4-oxadiazoles, and their structure-activity relationships are described. These compounds possessed excellent activity against Mycobacterium tuberculo...

UV irradiation of hitherto unknown 4,5-bis-benzo[b]thiophen-3-yl-[1,3]dithiol-2-one gave 3-(3-benzo[b]thienyl)-thieno[3,4-c]benzo[e][1,2]dithiine by loss of carbon monoxide and rearrangement, whereas 4,5-bis-(2-bromo-phenyl)-[1,3]dithiol-2-one gave a polymeric material containing S–S bridges. T...

Representatives of a new family, 1-aryl-3H-pyrrolo[2,1-d][1,2,5]triazepin-4(5H)-ones have been synthesized at our laboratory as bioisosters of biologically active 1-aryl-2,3-benzodiazepine-4-ones. The efficient synthetic route described applies the synthesis of 2-(2-aroylpyrrol-1-yl)acyl hydrazi...

Steroidal and non-steroidal aromatase inhibitors target the suppression of estrogen biosynthesis in the treatment of breast cancer. Researchers have increasingly focused on developing non-steroidal derivatives for their potential clinical use avoiding steroidal side-effects.Non-steroidal derivat...

The title compound (DPTA) synthesized by Knoevenagel Condensation process, was developed from a single crystal by slow evaporation method. This compound was then confirmed by FT-IR and FT-Raman spectroscopic analyses in order to identify the function groups. UV–visible spectral studies and fluo...

A new effective approach to the synthesis of some novel series of (Z)-2-((4-oxo-5-(thiophen-2-ylmethylene)-4,5-dihydrothiazol-2-yl)amino) substituted acid is reported at room temperature, less reaction time with good to excellent yields.