Excessive phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) plays a major role in the dysregulation of mRNA translation and the activation of tumor cell signaling. eIF4E is exclusively phosphorylated by mitogen-activated protein kinase interacting kinases 1 and 2 (MNK1/2) on...

It is shown that on intersection of 2-methyl-5-vinylpyridine (I) and dimethylaminoethylmethacrylate (II) with the quarternary of salt dimethylaminoethylmethacrylate with ethyl bromide (III) in an ethanolic medium at 313 K alternant copolymerization takes place. The interaction of compounds (I) a...

The emulsion polymerization of 2-methyl-5-vinylpyridine (MVP) initiated by potassium persulphate in the presence of two anionic emulsifiers, sodium lauryl sulphate (NaLS) and sodium oleate, was investigated. The effects of persulphate and emulsifier concentration on the rate of polymerization ar...

Cu(II) complexes of poly-2-vinylpyridine (P2VP) and poly-2-methyl-5-vinylpyridine (P2M5VP), partially quaternized by dimethylsulphate, and of the analogues (2-methyl-5-ethylpyridine, 2-ethylpyridine) were studied by EPR spectroscopy in a mixture of methanol and water. Peculiarities of the comple...

The molecular and compositional heterogeneity of polyampholytes formed by acrylic acid and 2-methyl-5-vinylpyridine having various compositions and molecular masses have been assessed by spectroturbidimetric titration. Fractionation of the copolymers has been carried out in the system methanol-t...

The interaction of polyampholyte based on 2-methyl-5-vinylpyridine and acrylic acid with copper(II) ions in aqueous solution has been investigated. Several types of complexes were formed, dependent on pH. The catalytic action of polyampholyte-copper(II) complex in hydrogen peroxide decomposition...

Thermodynamics of mixing two-component mixtures consisting of cellulose diacetate and poly(2-methyl-5-vinylpyridine) with dimethyl formamide has been studied over broad intervals of temperature and composition. The mixtures separate into two phases upon both heating and cooling, demonstrating th...

Copolymers of 2-methyl-5-vinylpyridine with acrylic acid have been studied by spectrophotometric titration in the UV region. It was found that the basic strength of the methylvinylpyridine groups increases as the proportion of acrylic acid units in the copolymer is increased, and the molar extin...

The basic laws governing phase separation in solutions of the synthetic polyampholytes formed by acrylic acid and 2-methyl-5-vinylpyridine have been studied. A reversible equilibrium transition from true solution to a polymeric dispersion is observed when the pH of the medium or the polymer conc...

A process of the graft polymerisation of 2-methyl-5-vinylpyridine induced by plasma on the surface of poly(ethylene terephthalate) track membranes (PET TM) was investigated. The surface properties and hydrodynamic properties of the composite membranes produced in this case have been studied. It ...

The variety of catalysts based on macroporous ion exchange resins using 2-methyl-5-vinylpyridine cross-linked with divinylbenzene (2M5VP/DVB) was investigated in the disproportionation of trichlorosilane (TCS) in a continuous-flow reactor. The effects of the reaction temperature and surface area...

The solid phase microextraction (SPME) has been the most used technique for the extraction of volatile compounds from rice because of its easy operation and solvent-free. The extraction parameters, sample mass and incubation temperature, were optimized through a central composite rotational desi...

Protein kinase casein kinase 2 (PKCK2) is a constitutively active, growth factor-independent serine/threonine kinase, and changes in PKCK2 expression or its activity are reported in many cancer cells. To develop a novel PKCK2 inhibitor(s), we first performed cell-based phenotypic screening using...

Ultrasound accelerates the formation of α-benzoylbenzyl cyanide and benzoic acid in the reaction of benzyl cyanide with potassium superoxide in the presence of 18-crown-6. Similarly, 4-methylbenzyl cyanide, 4-methoxybenzyl cyanide and 4-chlorobenzyl cyanide gave the corresponding α-(4-methylbe...

The chemical behaviour of alkyl substituted 2H-isoindoles towards dialkyl-azodicarboxylates has been investigated and the structure of the resulting 1:1- and 1:2-adducts elucidated. The reaction of the o-quinonoid hetarenes with the activated dienophiles can be considered as a Michael addition.

An enzyme assay for the metabolism of the carcinogenic aza-aromatic polycyclic compound 7-methylbenz[c]acridine has been developed using a modification of a radiochemical assay described for the polycyclic aromatic hydrocarbon benzo[a]pyrene by DePierre et al. [J. W. DePierre, M. S. Moron, K. A....

The potential K-region metabolites, trans- and cis-5,6-dihydroxy-7-methyl-5,6-dihydrobenz[c]acridine, 5,6-epoxy-7-methyl-5,6-dihydrobenz[c]acridine and 5-hydroxy-7-methylbenz[c]acridine, of 7-methylbenz[c]acridine have been synthesised.

A sensitive gas chromatographic procedure for the determination of 7-methylbenz[c]acridines (7-methyl-BAcs) is presented. The 7-methyl-BAcs are easily oxidized to 7-formylbenz[c]-acridines (7-formyl-BAcs) with periodic acid in dimethyl sulfoxide. The 7-formyl-BAcs are then reacted directly with ...

A synchronous fluorescence assay for the cochromatographing metabolites of 7-methylbenz[c]acridine, 7-hydroxymethylbenz[c]acridine and trans-7-methylbenz[c]-acridine-10,11-dihydrodiol is described and applied to the analysis of these metabolites formed by rat liver microsomes.

This program was designed to address the issue of the formation and toxicity of brominated dioxins and/or furans when formed as part of the soot and char in real fire environments. Results are reported from analytical and comparative animal toxicity studies conducted on soot and char samples gen...