Large signals from α-cyano-4-hydroxycinnamic acid (CHCA) matrix complexes with sodium and potassium ions were found to interfere with sensitive matrix-assisted laser desorption/ionization (MALDI) analysis of a hydrochloric acid digest of gelatine preparations. The nature of some selected matrix...

The ionization of phosphorylated peptides is usually suppressed by non-phosphorylated peptides when α-cyano-4-hydroxycinnamic acid (CHCA) is used as a matrix for matrix-assisted laser desorption/ionization-time-of-Flight (MALDI-TOF) mass spectrometry analysis. In the present study, we examined ...

In the present study, a comparative Raman vibrational analysis of alpha-cyano-4-hydroxycinnamic acid (4CHCA) and its derivative, alpha-cyano-3-hydroxycinnamic acid (3CHCA), was performed. The Raman spectra of the 4CHCA and 3CHCA in solid form were obtained and analyzed to determine differences b...

We report a sub-picosecond time-resolved fluorescence spectroscopic study of different cinnamic acid crystals, model systems for solid-state photodimerization reactions. For α-cyano-4-hydroxycinnamic acid (α-CHC), we identify the emission spectra of both monomers and dimers, allowing us to dir...

Alpha-cyano-4-hydroxycinnamic acid (4-CIN, 100–200 mg/kg b.wt.), which impairs glucose oxidation by inhibiting pyruvate transport across the mitochondrial membrane, stimulated feeding in rats following intraperitoneal injection without affecting blood glucose level. Like 2-deoxy-d-glucose (2-DG...

The effects of α-cyano-4-hydroxycinnamic acid (HCCA) on the activity of mushroom tyrosinase have been studied. Results showed that HCCA could inhibit both the monophenolase activity and diphenolase activity of mushroom tyrosinase. For the monophenolase activity, the lag phase was obviously leng...

The surface adsorption of organic nitrile compounds on the silver colloidal and island surfaces has been studied using surface-enhanced Raman scattering (SERS). α-Cyano-4-hydroxycinnamic acid (CHCA) with nitrile and carboxyl groups shows various surface adsorption on the silver surfaces. In aci...

Chlorophyll compounds possessing an N-(un)substituted pyrazole ring at the C3 position were synthesized by the reaction of chlorophyll-a derivative having a trifluoromethyl-β-diketonate group with (substituted) hydrazines in 2,2,2-trifluoroethanol through the pyrazoline ring. The substituents o...

The highly enantioselective synthesis of (R)-isopropyl 3-(3′,4′-dihydroxyphenyl)-2-hydroxypropanoate and its enantiomer has been achieved starting from 3,4-dihydroxybenzaldehyde. The stereogenic centers were established through asymmetric dihydroxylation of (E)-isopropyl 3,4-bis(benzyloxy) cin...

The preparative scale kinetic resolution of racemic ethyl 2- and 3-furyl- and 2- and 3-thienyl-3-hydroxypropanoates has been performed by Candida antarctica lipases A and B with vinyl esters. A study based on the present work together with the literature has been carried out in terms of lipase e...

Herein we present the lipase catalyzed synthesis of four new enantiomerically pure (R)- and (S)-ethyl 3-(2-arylthiazol-4-yl)-3-hydroxypropanoates and their butanoates by enzymatic enantioselective acylation of the racemic alcohols rac-1a–d and by ethanolysis of the corresponding racemic esters ...

The generation of arsane by reaction of either NaBH4 (THB) or NaBD4 (TDB) in aqueous solution with AsIII (1 mg L-1) has been studied in the presence of several transition and noble metals at trace levels. A continuous flow generation system coupled with both atomic absorption spectrometry (AAS) ...

A statistically significant QSAR model describing the bioactivity of bronchodilatory active 4H-pyrano[3,2-c]pyridine-3-carbonitriles (N = 41, n = 8, R2 = 0.824, R2cv = 0.724, F = 18.749, s2 = 0.0018) was obtained employing CODESSA-Pro software. The bronchodilatory active 4H-pyrano[3,2-c]pyridine...

The structural parameters of 4-(4-chlorophenyl)-2-oxo-1,2,5,6-tetrahydrobenzo[h]quinoline-3-carbonitrile (CPC) and 4-[4-(dimethylamino) phenyl]-2-oxo-1,2,5,6-tetrahydrobenzo[h]quinoline-3-carbonitrile (MAPC) dyes were determined with DFT at three functionals, vis. B3LYP, CAM-B3LYP and ωB97XD wi...

A facile synthetic approach towards 6-alkyl-2-amino-4-aryl-4a,5,6,7,8,8a-hexahydro-8a-methoxy-4H-pyrano[3,2-c]pyridine-3-carbonitriles 3a–n was reported via reaction of 1-alkyl-4-piperidones 1a,b with ylidenemalononitriles 2a–h in methanol in the presence of sufficient amount of sodium. The st...

In the present study a new series of 3-hydroxy-7-isocyano-6-oxo-8-phenyl-2-(substitutedphenyl(piperidin-1-yl)methyl)-6H-thiazolo-[3′,2′:2,3][1,2,4]triazolo[1,5-a]-pyridine-9-carbonitrile (5a–j) and (Z)-2-(4-substitutedbenzylidene)-7-isocyano-3,6-dioxo-8-phenyl-3,6-dihydro-2H-thiazolo-[3′,2′...

The extraction of titanium (IV) from sulfate, and nitrate solutions has been studied using tri-n-butyl phosphate (TBP) in kerosene. Extraction of titanium was affected by acid concentration over the range of 0.5–4 mol L−1. The titanium distribution coefficient reached a minimum between 1 and 2 ...

In this study, we report the preparation of CuCrO2-TiO2 composite by a self-combustion glycine nitrate process. The effects of glycine-nitrate ratios on the phase evolution and surface area of CuCrO2-TiO2 composite nanopowders were investigated. The precursor solution was prepared by adding glyc...

Polypyrrole titanium(IV)sulphosalicylophosphate (PPy-TSP) cation exchange nanocomposite was synthesized by in situ oxidative polymerization method. PPy-TSP membrane was prepared by solution casting method shows good results for ion-exchange capacity (IEC 0.91 meq/g), water content, porosity, thi...

A novel Poly-1-napthylamine-titanium(IV)sulphosalicylophosphate (PNA-TSP) cation exchange nanocomposite was synthesized by in-situ chemical oxidative polymerization of 1-naphthylamine in the presence of titanium(IV)sulphosalicylophosphate (TSP) nanoparticles. PNA-TSP doped with silver nanopartic...