Polyfunctional tetrahydro-2H-pyrano[3,2-c]pyridazin-3(6H)-one derivatives were synthesized and biologically evaluated as novel anticancer agents. These motifs were produced by a five-step reaction sequence in which the Achmatowicz oxidative cyclization, is the basic core for such synthesis. Comp...

A simple approach to 1,1′,2,2′,3,3′,4,4′-octahydro-1,1′-biisoquinolines is described. Reaction of phenethylamines with oxalyl chloride led to N,N′-bis(phenethyl) oxamides (1). Cyclization of oxamides by using Bischler – Napieralski conditions gave 3,3′,4,4′-tetrahydro-1,1′-biisoquinoli...

The photochemistry of (±)-3,4,4a,5,6,7-hexahydro-4a-methyl-7,7-diphenyl-1(2H)-naphthalenone (1) and (±)-3,4,4a,5,6,7-hexahydro-4a-7,7-trimethyl-1(2H)-napthalenone (2) is presented. Both molecules incorporate a rigid s-cis enone extended over two rings. In benzene, substrates 1 and 2 were photo...

6H-Naphtho[2,3-c]chromene-7,12-diones, to be considered as tetracyclic derivatives of the natural product pentalongin, were conveniently synthesized for the first time via palladium-catalyzed intramolecular cyclization of 2-bromo-3-aryloxymethyl-1,4-naphthoquinones.

Trichlorocyclotrithiazene (NSCl)3, reacts without ring cleavage with ethyloxirane, chloromethyloxirane and 7-oxabicyclo[4.1.0]heptane to give esters of the hypothetical parent acid (NS·OH)3, while impure products were obtained with oxirane, bromomethyloxirane and 3[4-chlorophenoxymethyl] oxirane.

1-Arylmethyl-2-(bromomethyl)azirdines were converted into the corresponding 2-(aryloxymethyl)aziridines upon treatment with the appropriate potassium phenoxides in DMF/acetone in excellent yields, followed by regioselective ring opening towards N,N-di(arylmethyl)-N-(2-bromo-3-aryloxypropyl)amine...

Self-diffusion and sorption of seven gases (He, H2, O2, N2, CH4, CO2, and Xe) in poly[bis(2,2,2-trifluoroethoxy)phosphazene] (PTFEP) have been investigated by molecular dynamics and Grand Canonical Monte Carlo (GCMC) simulations of two amorphous cells and an α-orthorhombic crystalline supercell...

Highly regioselective substitution reaction of 2,4-bis(2,2,2-trifluoroethoxy)-5-(trifluoromethyl)pyrimidine (TFEFP) with aniline derivatives smoothly proceeded firstly at the 2-postion. For the subsequent nucleophilic substitution at the 4-position with alkoxides, trifluoroethoxy group at the 4-...

With steroid as a carrier nucleus and introducing a pyridine heterocycle as a pharmacophore on the D ring, a series of steroidal pyridine derivatives were designed and studied for their antitumor activity by molecular docking software. The compounds were synthesized as small molecule inhibitors ...

The structure of 3-benzyloxy-2-nitropyridine has been investigated both experimentally and theoretically. The X-ray crystallography results show that the nitro group is tilted out of the pyridine ring plane by 66.4(4)°, which is mainly attributed to the electron–electron repulsions of the lone...

A practical and rapid preparation of 3-benzyloxy-4-bromo and 3-benzyloxy-5-bromopicolinate esters 10 and 16 was developed in four steps, respectively, in 38% and 31% overall yield. Then their viability as partners for cross-coupling reactions has been evaluated in Suzuki–Miyaura, Hartwig–Buchw...

Human Diphtheria toxin-like ADP-ribosyltranferases (ARTD) 10 is an enzyme carrying out mono-ADP-ribosylation of a range of cellular proteins and affecting their activities. It shuttles between cytoplasm and nucleus and influences signaling events in both compartments, such as nuclear factor kapp...

Biodegradable lubricants (esters) are a logical solution to avoid the environmental threat of mineral lubricants disposal. This research reports the enzymatic synthesis and characterization of new biodegradable lubricants obtained via the transesterification of different methyl fatty acids ester...

A new polyfunctional acrylate monomer (COPERAA) was synthesized from castor oil and utilized as a sustainable reactive diluent for UV-curable materials. Firstly, experimental conditions for the synthesis of the monomer were optimized and its chemical structures were confirmed by FT-IR, 1H NMR, a...

We performed two-step enzymatic biolubricant production: castor oil hydrolysis and esterification of castor oil free fatty acids (COFFA) rich in ricinoleic acid. The hydrolysis step utilized castor seeds as catalyst yielding 93.13 ± 5.9% COFFA in only 1 h. In the esterification step, C. rugosa ...

The i.r. spectra of forty-one 1,2,3-dioxaphophorinans have been studied. The dependence of the phosphoryl frequency upon the conformation of the heterocycle is discussed. The characteristic absorption frequencies associated with P → S, P—Cl, P—C6H5 and P—O—C6H5 bonds are given.

A series of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)pyrazoles 14a–e, 15a–e, 17a–c, and 18a–d have been synthesized and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. The 6-quinolinyl pyrazole analogue 14b inhi...

A series of 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5(3)-(6-methylpyridin-2-yl)imidazoles and -pyrazoles 14a–c, 15a–c, 16a, 16b, 19a–d, 21a, and 21b has been synthesized and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. Among the...

A series of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles 14a–d, 15a–d, 17a, 17b, 18a–d, 19a, and 19b has been synthesized and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. The 2-[3-(6-methylpyridin-2-yl...

In order to evaluate the actual pros and cons in the use of new nitroamines for solid rocket applications, the combustion properties of double-base propellants containing nitrogen heterocyclic nitroamines such as RDX, TNAD, HMX and DNP are investigated by means of high-speed photography techniqu...