Sodium methoxide in tetrahydrofuran attacks silicon in allyl(chloromethyl)dimethylsilane and in (chloromethyl)dimethylvinylsilane with displacement of chloride and 1,2-migration of the allyl and the vinyl groups to give 1-(3-butenyl)methoxydimethylsilane and allylmethoxydimethylsilane.

The miscibility behaviour of poly(chloromethyl methacrylate) (PCMMA) with various polymethacrylates was examined by differential scanning calorimetry and for lower critical solution temperature behaviour. PCMMA is miscible with poly(methyl methacrylate) (PMMA), poly(ethyl methacrylate) (PEMA), p...

Publisher SummaryThis chapter focuses on the peptide chloromethyl ketones as labeling reagents. The synthesis of the chloromethyl ketone group generally involves the reaction of a blocked amino acid with a chloroformate to produce a mixed anhydride. In these reactions, the principal difficulties...

Pharmacological properties of native carrageenan (κ) extracted from Kappaphycus alvarezii and commercial carrageenan (Sigma-Aldrich) were evaluated using in vitro antioxidant, anticancer and antidiabetic studies. Phytochemical analysis of native and commercial carrageenans showed the presence o...

Polysaccharide-surfactant blends are widely used in foods. However, their possible mutual interactions have not been extensively studied. The purpose of this work was to examine how the anionic surfactant sodium stearoyl lactylate (SSL) affects different properties of κ-carrageenan solutions an...

The oxidized κ-carrageenans with different oxidation levels were prepared through the hydrogen peroxide and copper sulfate redox system. The oxidation level of oxidized κ-carrageenan was successfully controlled by adjusting the dosage of hydrogen peroxide. The results showed that the microtopo...

Novel multiresponsive hybrid biocompatible systems of κ-carrageenan-graft-poly(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)s with unique combination of responsiveness to external stimuli were synthesized and studied. The polymer thermoresponsive behavior proved the existence of both lower an...

Different hydrolysis conditions to produce κ-carrageenan oligosaccharide alditols were studied and the depolymerization process monitored by capillary electrophoresis (CE). Semisynthesis, ion-exchange and exclusion chromatography were used to obtain and isolate sulfated di-, tetra- and hexasacc...

Biopolymer, a natural biodegradable polymer has attracted much attention in recent years. Global environmental awareness and fossil fuel depletion urged researchers to work in the biopolymer field. Some of the biopolymers used for the fabrication of rechargeable batteries are cellulose, chitosan...

This study investigated the chain conformation, microstructure, and rheological properties of a quaternary ammonium salt of curdlan (Qcurd) in aqueous medium. Results showed that Qcurd exhibited typical polyelectrolyte behavior in pure water, and the normal viscosity character was observed in 0....

In this study, we analyzed the contribution of NH4I and glycerol on the ionic conductivity of carboxymethyl κ/ι-hybrid carrageenan-based solid bio-electrolytes. Electrochemical impedance spectroscopy was used to assess the electrochemical properties of the developed biopolymeric films and thei...

Bio-polymer electrolyte iota-carrageenan (Ι-carrageenan) with ammonium nitrate (NH4NO3) has been prepared by solution-casting technique. The increase in amorphous nature of the bio-polymer electrolyte due to the addition of salt has been confirmed by X-ray diffraction analysis. From the XRD spe...

Bio- polymer electrolytes based on iota- carrageenan with ammonium formate (NH4HCO2) in different concentrations have been prepared by solution casting technique. FTIR analysis confirms the complex formation between the polymer and salt. The highest conductivity at ambient temperature has been f...

The reaction of N-unprotected methylesters of phenylglycine derivatives (1a–1f) with electron-rich internal alkynes (2a–2e), catalyzed by [Ru(cymene)Cl2]2 (10%), gives the corresponding 3,4-disubstituted isoquinoline-1-carboxylates 3 through CH/NH oxidative coupling. The CH bond activation ste...

CuI/trans-4-hydroxy-l-proline catalyzed coupling of aryl iodides with tert-butyl β-keto esters proceeded smoothly at 40 °C in DMF, providing α-aryl ketones after acid-promoted deprotection and decarboxylation of tert-butyl ester group. While CuI/2-picolinic acid catalyzed coupling of aryl iod...

Triazolinedione quenches efficiently the 1,2-dipoles from Schiff bases of glycine esters which are formed via a [1,2-H]-prototropic shift of their α-hydrogens, and affords the respective α-aminated products in good yields. Competition experiments show a stabilization of the 1,2-dipole from the...

Selenium-containing amino acids play a pivotal role as biomaterials for the synthesis of Se-dependent enzymes and repair proteins. Especially, selenocysteine and selenoglutathione are prominently involved in fundamental biological processes. In this study, a series of selenocysteine (Sec) and se...

The reaction rates were determined at 25 and 37° of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) with a number of nucleophiles in water. The rate of the primary reaction step was dependent on the nucleophilicity and the basicity of the att...

Antimony(III) chloride (20 mol %) in refluxing acetonitrile efficiently catalyses the synthesis of dihydropyrimidinones (50–90% yields) by the Biginelli reaction of aromatic aldehydes, acetoacetate esters and urea. This reaction proceeds through 3-ureido-crotonates followed by cyclisation with ...

Screening a 3-aminopyridin-2-one based fragment library against a 26-kinase panel representative of the human kinome identified 3-amino-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2(1H)-one (2) and 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one (3) as ligand efficient inhibitors of the mitotic kinase Monopol...