Two novel Schiff bases 2-((pyridin-4-yl)methelenamino)-3-aminomaleonitrile (L1) and 2,3-bis((pyridin-yl)methylenamino)maleonitrile (L2) were synthesized by the condensation of 2,3-diaminomaleonitrile and 4-pyridine carboxaldehyde using the reflux in absolute methanol. The light yellow crystallin...

The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) induces nephrotoxicity as its major toxicity in rats. Previous studies have shown that NDPS induces nephrotoxicity following oxidation of the succinimide ring to form N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and the hy...

In vivo metabolism, nephrotoxicity and covalent binding to proteins were evaluated in male Fischer 344 rats that received [2,3-14C]-N-(3,5-dichlorophenyl)succinimide (14C-NDPS). Some animals were pretreated with the enzyme inducer phenobarbital (PB, 80 mg/kg per day, for 3 days, i.p. in saline) ...

Amlodipine besylate (AMB) is a synthetic dihydropyridine calcium channel blocker with antihypertensive and anti-anginal effects. Quantum computational investigations on AMB were done using DFT/B3LYP/6-311++G (d, p) level of theory, to study the molecular structural properties, nonlinear properti...

Increasing numbers of elderly people require multi-drug therapies. One route to improve adherence rates is to prepare fixed dose combinations (FDCs), in which multiple active ingredients are loaded into a single formulation. Here, we report the use of electrospinning to prepare fast-dissolving o...

Digoxigenin-labeled RNA probes and in situ hybridization histochemistry were used to examine choline acetyltransferase gene expression in the rat central nervous system. Hybridization signal was present only in brain sections processed with the antisense riboprobe. The sense probe did not yield ...

Digoxigenin-labeled riboprobes and in situ hybridization of choline-O-acetyltransferase mRNA, both alone and in combination with immunohistochemical procedures for the synthetic enzyme of acetylcholine, were used to map the topography of putative cholinergic neurons in the rat central nervous sy...

N4-(2-Acetoxyethoxymethyl)-2-acetylpyridine thiosemicarbazone (AATSC) belongs to a series of molecules known to have broad antimicrobial inhibitory activity. These molecules contain the 2-acetoxyethoxy moiety which could conceivably take up a conformation analogous to that of the ribosyl group. ...

A series of thiosemicarbazones and thioureas having an open-chain analogue of the ribosyl group, the 2-acetoxyethoxymethyl moiety, has been synthesized. Significant growth inhibitory activity versus gram-positive and gram-negative organisms, a yeast, and a mold has been found with the 2-acetoxye...

The Diels-Alder reaction between 3-fluorobenzyne (1) and 2-alkylfurans (2) gives a mixture of syn adduct 3 and anti adduct 4. The syn cycloadduct invariably predominates and the regioselectivity increases in the order: R = Me

1-(2-Hydroxyethyl)-3-substituted-2-methyl-2-thiopseu-dourea hydriodides, when heated in polar solvents, were found in many instances to result in the formation of 2-amino-2-oxazoline derivatives with the simultaneous evolution of methyl mercaptan. The rate of the reaction is apparently influence...

Immobilized CAL-B catalyzed kinetic resolution of syn-7-bromo-3-(1′-hydroxyethyl)-1-methyl-5-(2′-pyridyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one syn-(±)-2 and its anti-diastereomer (±)-3 were achieved with E-values over 200. Completely enantioselective acetylation of (1′R)-enantiomers in di...

The main aim of the work is to investigate ionic liquids (ILs) or zwitterionic compound (ZI) as anti-crystallization additives for {LiBr (1) + water (2)} system, conventionally used as a working pair in absorption refrigeration technology. In this study, solubility of lithium bromide in water ha...

Inflammation is a primary event in atherogenesis. Oleoylethanolamide (OEA), a naturally occurring fatty-acid ethanolamide, lowers lipid levels in liver and blood through activation of the nuclear receptor, peroxisome proliferator-activated receptor-alpha (PPARα). We designed and synthesized (Z)...

Various ionic liquids (ILs) were prepared via metathesis reaction from two kinds of 1-(2-hydroxyethyl)-3-methyl imidazolium ([HEMIm]+) and N-(2-hydroxyethyl)-N-methyl morphorinium ([HEMMor]+) cations and three kinds of tetrafluoroborate ([BF4]−), bis(trifluoromethanesulfonyl)imide ([TFSI]−) and ...

The reaction of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole (Metronidazole) with salts of biologically active arylchalcogenylacetic acids affords novel perspective physiologically active metal complexes.

The liquid–liquid equilibrium behavior is important when describing the separation of components involved in alkyl ester production during the glycerol-settling step. Therefore, this study presents original data on a liquid–liquid equilibrium system composed of glycerol + ethanol + ethyl ester...

Reaction of lithium diphenylphosphinocyclopentadienide with YCl3 or YCl3(THF)3 and working lead to the formation of three yttrocene phosphines: the lithium metal adduct isolated as (Ph2PC5H4)2Y(μ-Cl)2Li(THF)2 · 0.5 LiCl (1), the chloride-bridged dimeric species {(Ph2PC5H4)2Y(μ-Cl)}2 (2), and ...

A kind of less platinum hydrogen evolution reaction (HER) catalyst, 3%Pt/WC/C10, is successfully synthesized using a simple in-situ platinum reduction method of directly mixing WC/C10 and chloroplatinic acid in deionized water and then drying. The structure and morphology are mainly characterize...

MGAT2 (monoacylglycerol acyltransferase 2) is expected to be an attractive target for the drug treatment of obesity, diabetes, and other disease. We describe our exploration and structure–activity relationship (SAR) study of 2,3-dihydro-1H-isoindole-5-sulfonamide derivatives. In this study, we ...