Cinacalcet Cas no. 226256-56-0 Cinacalcet Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional team
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:226256-56-0
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:226256-56-0
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:226256-56-0
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:226256-56-0
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Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:226256-56-0
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.
Cas:226256-56-0
Min.Order:1 Kilogram
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:226256-56-0
Min.Order:10 Gram
FOB Price: $146.0 / 176.0
Type:Trading Company
inquiryProduct name Cinacalcet CAS NO. 226256-56-0 Synonyms Cinacalcet hydrochloride Category Pharmaceutical Raw Materials,Active Pharm
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:226256-56-0
Min.Order:1 Kilogram
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inquiryWuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides
Cas:226256-56-0
Min.Order:100 Kilogram
FOB Price: $1.0 / 5.0
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:226256-56-0
Min.Order:1 Kilogram
FOB Price: $2000.0 / 2500.0
Type:Trading Company
inquiryCINACALCET CAS:226256-56-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat
Cas:226256-56-0
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:226256-56-0
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:226256-56-0
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Type:Lab/Research institutions
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:226256-56-0
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inquiryProduct Detail Minimum Order Qty. 10 Gram
Cas:226256-56-0
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:226256-56-0
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Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:226256-56-0
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryHigh Quality API 99% Cinacalcet CAS 226256-56-0 powder price IN STOCKAppearance:powder Storage:dry and cool place Package:according to customers' requirements Application:Pharmaceutical,Used as pharmaceutical intermediates Transportation:By air(EMS o
Cas:226256-56-0
Min.Order:1 Gram
Negotiable
Type:Other
inquirySuperior quality Appearance:Yellow Oil Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:Cinacalcet is the first calcimimetic drug approved by the
Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Product name: Cinacalcet CAS No.: 226256-56-0 Molecule Formula:C22H22F3N Molecule Weight:357.41 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTIN
Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
CINACALCET Basic information Product Name: CINACALCET Synonyms: CINACALCET;(aR)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine;AMG 073;(aR)-a-Methyl-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine;N-((
(1R)-1-(naphthalen-1-yl)ethanamine (R)-mandelate
methylsulfonyl-3-(3-trifluoromethylphenyl)propyl ester
cinacalcet
Conditions | Yield |
---|---|
With potassium carbonate In water at 60 - 65℃; for 20h; | 100% |
(R)-1-(1-Naphthyl)ethylamine
3-[3-(trifluoromethyl)phenyl]propan-1-ol
cinacalcet
Conditions | Yield |
---|---|
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; D-sorbitol; choline chloride at 60℃; for 12h; | 98% |
Stage #1: 3-[3-(trifluoromethyl)phenyl]propan-1-ol With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene In dichloromethane at 20℃; for 2h; Stage #2: (R)-1-(1-Naphthyl)ethylamine With sodium tris(acetoxy)borohydride In dichloromethane optical yield given as %ee; | 84% |
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydrogencarbonate In toluene at 110℃; for 17h; Inert atmosphere; Sealed tube; | 75% |
With C19H22MnN3O3P(1+); potassium hydride In 1,2-dimethoxyethane at 100℃; for 48h; Glovebox; Sealed tube; Inert atmosphere; | 50% |
cinacalcet hydrochloride
cinacalcet
Conditions | Yield |
---|---|
With sodium carbonate In dichloromethane; water | 96% |
With water; sodium carbonate In di-isopropyl ether at 25℃; for 2.25h; pH=9.5; |
cinacalcet
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water for 0.5h; pH=9 - 10; | 96% |
α,α,α-trifluorotoluene
cinacalcet
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at 0℃; for 2h; | 95.6% |
cinacalcet
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In ethanol under 1520.1 Torr; for 2h; Pressure; | 95% |
With hydrogen; palladium on activated carbon In methanol for 14h; Product distribution / selectivity; | 90% |
With hydrogen; 5%-palladium/activated carbon In toluene at 10 - 30℃; under 152.01 - 1140.08 Torr; Industry scale; | 79.4% |
(R)-N-[3-[3-(trifluoromethyl)phenyl]-2-propenylimino]-N-[1-(1-naphthyl)ethylamine]
cinacalcet
Conditions | Yield |
---|---|
With hydrogen In ethanol at 80℃; under 7500.75 Torr; for 3h; High pressure; | 95% |
1-(3-iodopropyl)-3-(trifluoromethyl)benzene
(R)-1-(1-Naphthyl)ethylamine
cinacalcet
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 70℃; for 12h; | 95% |
cinacalcet
Conditions | Yield |
---|---|
With hydrogenchloride; zinc In water at 20℃; pH=< 1; | 94.1% |
With hydrazine hydrate; potassium hydroxide In ethanol at 90 - 180℃; for 2h; Solvent; | 83.5% |
1'-naphthacetophenone
3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine
cinacalcet
Conditions | Yield |
---|---|
With titanium(IV) isopropylate; hydrogen; 1,8-diazabicyclo<5.4.0>undec-7-ene hidrochloride In acetic acid methyl ester at 50℃; under 38002.6 Torr; for 20h; Reagent/catalyst; Solvent; stereoselective reaction; | 94% |
(E)-N-((R)-1-naphthalen-1-yl-ethyl)-3-(3-trifluoromethyl-phenyl)-acrylamide
cinacalcet
Conditions | Yield |
---|---|
Stage #1: (R)-N-(1-naphthalen-1-yl-ethyl)-3-(3-trifluoromethyl-phenyl)-(E)-acrylamide With dimethylsulfide borane complex In toluene at 50℃; for 3h; Stage #2: With hydrogenchloride; water In toluene at 50℃; for 1h; Product distribution / selectivity; | 93% |
With diisobutylaluminium hydride In dichloromethane; toluene at 50℃; for 1.5h; Product distribution / selectivity; | 60% |
Stage #1: (R)-N-(1-naphthalen-1-yl-ethyl)-3-(3-trifluoromethyl-phenyl)-(E)-acrylamide With lithium aluminium tetrahydride In tetrahydrofuran at 64℃; for 23.3333h; Stage #2: With water; ethyl acetate In tetrahydrofuran at 0 - 10℃; for 0.25h; Product distribution / selectivity; | |
Stage #1: (R)-N-(1-naphthalen-1-yl-ethyl)-3-(3-trifluoromethyl-phenyl)-(E)-acrylamide With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene at 30 - 55℃; for 8h; Stage #2: With water; Rochelle's salt In toluene at 5℃; for 0.75h; Product distribution / selectivity; |
3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine
cinacalcet
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 5h; | 93% |
(R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide
cinacalcet
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 10h; | 92% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 10h; Schlenk technique; Inert atmosphere; | 92% |
With borane-ammonia complex; boron trifluoride diethyl etherate; tris(pentafluorophenyl)borate In 1,2-dichloro-ethane at 60℃; | 83% |
(R)-1-(1-Naphthyl)ethylamine
3-[3-(trifluoromethyl)phenyl]propanal
cinacalcet
Conditions | Yield |
---|---|
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 3-[3-(trifluoromethyl)phenyl]propanal With tris(pentafluorophenyl)borate In toluene at 20℃; Molecular sieve; Stage #2: With ammonia borane In toluene at 20℃; for 12h; Molecular sieve; enantioselective reaction; | 92% |
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 3-[3-(trifluoromethyl)phenyl]propanal In tetrahydrofuran for 0.25h; Stage #2: With sodium tris(acetoxy)borohydride; acetic acid In tetrahydrofuran for 2h; Stage #3: With sodium carbonate In dichloromethane; water Product distribution / selectivity; | 89% |
With triethylsilane; palladium on carbon; TPGS-750-M In water at 45℃; for 7h; | 88% |
1'-naphthacetophenone
3-(3-trifluoromethyl-phenyl)-propylamine hydrochloride
cinacalcet
Conditions | Yield |
---|---|
With titanium(IV) isopropylate; hydrogen In ethyl acetate at 50℃; under 38002.6 Torr; for 20h; stereoselective reaction; | 91% |
3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine
cinacalcet
Conditions | Yield |
---|---|
With triethylamine In methanol at 20℃; for 3h; | 90% |
(R)-1-(1-Naphthyl)ethylamine
3-(3-trifluoromethylphenyl)propanoic acid
cinacalcet
Conditions | Yield |
---|---|
With tris(pentafluorophenyl)borate; phenylsilane In dibutyl ether at 120℃; for 24h; Solvent; Reagent/catalyst; Concentration; Inert atmosphere; Schlenk technique; | 89% |
With tris(pentafluorophenyl)borate; phenylsilane In dibutyl ether at 120℃; for 20h; Schlenk technique; Inert atmosphere; | 87% |
With potassium phosphate; 18-crown-6 ether; phenylsilane In tetrahydrofuran at 80℃; for 36h; Glovebox; Molecular sieve; Schlenk technique; |
(1R)‐1‐(naphthalen‐1‐yl)ethyl methanesulfonate
3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine
cinacalcet
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 8.5h; | 86% |
cinacalcet
Conditions | Yield |
---|---|
With sodium tetrahydroborate; boron trifluoride diethyl etherate In tetrahydrofuran at 50 - 60℃; for 3h; Reagent/catalyst; Temperature; Flow reactor; | 83.5% |
1-vinylnaphthalene
B
cinacalcet
Conditions | Yield |
---|---|
With diethoxymethylane; (S)-DTBM-SEGPHOS; copper diacetate; triphenylphosphine In tetrahydrofuran at 20℃; for 16h; Inert atmosphere; Glovebox; enantioselective reaction; | A n/a B 82% |
cinacalcet
Conditions | Yield |
---|---|
With lithium hydroxide monohydrate In N,N-dimethyl-formamide; toluene at 25℃; for 2h; | 81% |
With lithium hydroxide monohydrate; mercaptoacetic acid In acetonitrile Inert atmosphere; Reflux; Autoclave; Large scale; |
cinacalcet
Conditions | Yield |
---|---|
With C46H36BF10P; hydrogen In toluene at 40℃; under 150015 Torr; for 8h; Autoclave; Inert atmosphere; | 80% |
1-(3-bromopropyl)-3- (trifluoromethyl)benzene
(1R)-1-(1-naphthyl)-N-(phenylmethylene)ethanamine
cinacalcet
Conditions | Yield |
---|---|
Stage #1: 1-(3-bromopropyl)-3- (trifluoromethyl)benzene; (1R)-1-(1-naphthyl)-N-(phenylmethylene)ethanamine With potassium iodide at 120 - 130℃; Stage #2: With hydrogenchloride; water In acetonitrile at 25 - 35℃; for 1h; pH=1 - 2; Stage #3: With ammonia In water pH=9 - 10; Product distribution / selectivity; | 71% |
(R)-1-(1-Naphthyl)ethylamine
cinacalcet
Conditions | Yield |
---|---|
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 3-(3-trifluoromethylphenyl)propanoyl succinimide In tetrahydrofuran at 20℃; Inert atmosphere; Stage #2: With lithium aluminium tetrahydride In tetrahydrofuran for 48h; Reflux; | 57% |
3-(trifluoromethyl)styrene
carbon monoxide
(R)-1-(1-Naphthyl)ethylamine
cinacalcet
Conditions | Yield |
---|---|
With hydrogen; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In methanol; toluene at 125℃; for 8h; Product distribution / selectivity; | 53.8% |
3-(3-trifluoromethyl-phenyl)-propynoic acid ((R)-1-naphthalen-1-yl-ethyl)-amide
cinacalcet
Conditions | Yield |
---|---|
Stage #1: 3-(3-trifluoromethyl-phenyl)-propynoic acid ((R)-1-naphthalen-1-yl-ethyl)-amide With dimethylsulfide borane complex In toluene at 50℃; for 7h; Stage #2: With hydrogenchloride; water In methanol; toluene at 90℃; for 4h; Product distribution / selectivity; | 22% |
(2E)-N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine
cinacalcet
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon at 20℃; under 760.051 Torr; for 16h; | |
With formic acid; palladium dichloride In ethanol for 5h; Product distribution / selectivity; Reflux; |
(R)-1-(1-Naphthyl)ethylamine
1-(3-chloropropyl)-3-(trifluoromethyl)benzene
cinacalcet
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 81.7℃; for 5 - 22h; Product distribution / selectivity; Heating / reflux; | |
With potassium carbonate In water; toluene at 85℃; for 20h; Product distribution / selectivity; | |
With potassium carbonate In toluene for 14h; Product distribution / selectivity; Heating / reflux; | |
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 1-(3-chloropropyl)-3-(trifluoromethyl)benzene With potassium carbonate In toluene at 80℃; for 12h; Stage #2: With tetrabutylammomium bromide In toluene at 80℃; for 1h; Product distribution / selectivity; |
cinacalcet
Conditions | Yield |
---|---|
With sodium tetrahydroborate; iodine In tetrahydrofuran for 4h; Heating; |
cinacalcet
acetic acid
N-[1-(R)-(-)-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane acetate
Conditions | Yield |
---|---|
In 2-methylpropyl acetate; water at 20℃; for 5.5h; | 99.8% |
In water; isopropyl alcohol Product distribution / selectivity; | 88% |
In water; toluene at 30℃; for 3.5h; |
cinacalcet
cinacalcet hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In n-heptane; ethyl acetate at 20℃; | 95% |
With hydrogenchloride In acetonitrile at 25 - 55℃; for 0.2h; | 93.1% |
With hydrogenchloride In n-heptane; water; toluene at 25 - 30℃; pH=1 - 2; Product distribution / selectivity; | 92.55% |
cinacalcet
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 50℃; for 5h; Temperature; | 94.7% |
cinacalcet
carbonochloridic acid 1-chloro-ethyl ester
1-chloroethyl carbamate cinacalcet
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 3h; | 94% |
Conditions | Yield |
---|---|
Stage #1: 1-Adamantanethiol With C20H18N2O4S4 In dichloromethane at 0℃; for 0.0833333h; Stage #2: cinacalcet With dmap In dichloromethane at 0 - 20℃; for 1h; | 90% |
cinacalcet
carbon dioxide
(R)-N-methyl-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine
Conditions | Yield |
---|---|
With 3-benzyl-5-(2-hydroxy-ethyl)-4-methyl-thiazolium betaine In N,N-dimethyl acetamide at 100℃; under 760.051 Torr; | 83% |
With diphenylsilane; [1,3-bis(2,4,6-trimethylphenyl)imidazol]-2-ylidene In N,N-dimethyl-formamide at 50℃; under 760.051 Torr; chemoselective reaction; | 78% |
With cyclopentadienyl iron(II) dicarbonyl dimer; phenylsilane; triphenylphosphine In acetonitrile at 100℃; under 760.051 Torr; for 24h; Schlenk technique; Sealed tube; | 70% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 100℃; under 760.051 Torr; for 48h; Schlenk technique; | 54% |
Conditions | Yield |
---|---|
With caesium carbonate In dimethyl sulfoxide at 20℃; chemoselective reaction; | 82% |
Conditions | Yield |
---|---|
In ethanol at 5 - 65℃; for 0.5h; | 80.22% |
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