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Yangzhou Qinyuan Pharmatech Co.,Ltd

Cas no. 585-50-2 3-(3-Trifluoromethylphenyl)propionic acid API or Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufactu

3-(3-Trifluoromethylphenyl)propionic acid

Cas:585-50-2

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

3-(3-Trifluoromethylphenyl)propionic acid

Cas:585-50-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

3-(3-Trifluoromethylphenyl)propionic acid CAS No.:585-50-2 Name: 3-(3-Trifluoromethylphenyl)propionic acid Molecular Structure Molecular

High purity 3-(3-Trifluoromethylphenyl)propionic acid CAS No.:585-50-2

Cas:585-50-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

3-(3-TrifluoroMethylphenyl)propionic Acid

Cas:585-50-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-[3-(Trifluoromethyl)-phenyl]-propionic acid

Cas:585-50-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Chengdu words and import and export co., LTD is one specialized is engaged in pharmaceutical intermediates, fine chemical industry in the field of research. Development and production of high-tech enterprises.We can provide Ephedrine products to ne

3-(3-(Trifluoromethyl)phenyl)propanoic acid

Cas:585-50-2

Min.Order:500 Gram

FOB Price: $900.0 / 1200.0

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1172.html Product Name 3-(3-Trifluoromethylphenyl)propionic acid CAS No.

3-(3-Trifluoromethylphenyl)propionic acid

Cas:585-50-2

Min.Order:1 Gram

FOB Price: $11.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--585-50-2--3-(3-Trifluoromethylphenyl)propionic acid factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established

TIANFUCHEM--585-50-2--3-(3-Trifluoromethylphenyl)propionic acid factory price

Cas:585-50-2

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

3-(3-Trifluoromethylphenyl)propionic acid

Cas:585-50-2

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 585-50-2 with fast shipping

Cas:585-50-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

3-(3-Trifluoromethylphenyl)propionic acid Product name 3-(3-Trifluoromethylphenyl)propionic acid Synonyms Hydrocinnamicacid, m-(trifluoromethyl)- (7CI,8CI) CAS No. 585-50

3-(3-Trifluoromethylphenyl)propionic acid

Cas:585-50-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

3-(3-Trifluoromethylphenyl)propionic acid 585-50-2

Cas:585-50-2

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla

High purity 3-(3-Trifluoromethylphenyl)propionic acid cas no 585-50-2

Cas:585-50-2

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzenepropanoic acid,3-(trifluoromethyl)- 585-50-2

Cas:585-50-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply 3-(3-Trifluoromethylphenyl)propionic acid CAS 585-50-2 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Ma

3-(3-Trifluoromethylphenyl)propionic acid CAS 585-50-2

Cas:585-50-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzenepropanoic acid,3-(trifluoromethyl)-

Cas:585-50-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:585-50-2

Cas:585-50-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 3-(3-Trifluoromethylphenyl)propionic acid Synonyms: RARECHEM AL BO 1070;3-(3'-TRIFLUOROMETHYLPHENYL)-PROPIONIC ACID;3-Trifluoromethylbenzenepropanoic acid;3-(3-Trifluoromethylphenyl)propionic acid ,97%;3-(3-TRIFLUOROMETHYLPHENY

3-(3-Trifluoromethylphenyl)propionic acid Manufactuered in China best quality

Cas:585-50-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance: White or off-white Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:S

3-(3-Trifluoromethylphenyl)propionic acid

Cas:585-50-2

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-(3-Trifluoromethylphenyl)propionic acid

Cas:585-50-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

3-(3-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID 585-50-2

Cas:585-50-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Acetic acid,2,2'-[carbonothioylbis(thio)]bis-

Cas:585-50-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

3-(3-Trifluoromethylphenyl)propionic acid

Cas:585-50-2

Min.Order:1 Gram

Negotiable

Type:Other

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Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci

3-(3-Trifluoromethylphenyl)propionic acid CAS 585-50-2

Cas:585-50-2

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3-(3-TrifluoroMethylphenyl)propionic Acid

Cas:585-50-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 3-(3-Trifluoromethylphenyl)Propionic Acid CAS No.:585-50-2 Molecule Formula:C10H9F3O2 Molecule Weight:218.17 Purity: 99.0% Package: 200kg/drum Description:Yellow liquid Manufacture Standards:Enterprise Standard TEST

High Quality 3-(3-Trifluoromethylphenyl)Propionic Acid in stock

Cas:585-50-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3-(3-Trifluoromethylphenyl)propionic acid

Cas:585-50-2

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

3-(3-Trifluoromethylphenyl)propionic acid Chemical Properties Melting point 35°C(lit.) Boiling point 149°C/11mmHg(lit.) density 1.307±0.06 g/cm3(Predicted) storage temp. Sealed in dry,Room Temperature pka 4.56&plusmn

3-(3-Trifluoromethylphenyl)propionic acid

Cas:585-50-2

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3-(3-Trifluoromethylphenyl)propionic acid

Cas:585-50-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3-(3-Trifluoromethylphenyl)propionic acid

Cas:585-50-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Synthetic route

3-(trifluoromethyl)cinnamic acid
779-89-5

3-(trifluoromethyl)cinnamic acid

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

Conditions
ConditionsYield
With hydrogen; palladium dihydroxide at 40 - 60℃; under 2250.23 Torr;100%
With palladium on activated charcoal; hydrogen; sodium carbonate In water at 25℃; under 1500.15 - 2250.23 Torr; for 3h;99.4%
With hydrogen; palladium on activated charcoal In methanol at 20 - 25℃; under 30.003 Torr;95.2%
3-(trifluoromethyl)cinnamic acid
779-89-5

3-(trifluoromethyl)cinnamic acid

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

Conditions
ConditionsYield
With hydrogen; 5% Pd(II)/C(eggshell) In methanol at 25℃; under 735.572 Torr; for 10h;100%
Stage #1: 3-(trifluoromethyl)cinnamic acid With palladium diacetate; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In dichloromethane at 25℃; for 12h; Schlenk technique; Inert atmosphere;
Stage #2: With hydrogenchloride In water
97%
With palladium diacetate; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In dichloromethane at 25℃; for 12h; Sealed tube; Inert atmosphere; chemoselective reaction;97%
3-(3-(trifluoromethyl)phenyl)propanenitrile
95096-06-3

3-(3-(trifluoromethyl)phenyl)propanenitrile

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

Conditions
ConditionsYield
With hydrogenchloride; water for 4.5h; Product distribution / selectivity;94%
With sodium hydroxide; water In ethylene glycol at 125℃; for 9h; Product distribution / selectivity;
2-vinyl-1,3-dioxolane
3984-22-3

2-vinyl-1,3-dioxolane

3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

Conditions
ConditionsYield
Stage #1: 2-vinyl-1,3-dioxolane; 3-bromo-1-trifluoromethylbenzene With potassium carbonate; Pd-Tedicyp catalyst In N,N-dimethyl-formamide at 110℃; for 20h; Heck reaction;
Stage #2: With sodium hydroxide; water In N,N-dimethyl-formamide at 50 - 80℃;
93%
(E)-2-Oxo-4-(3-trifluoromethyl-phenyl)-but-3-enoic acid

(E)-2-Oxo-4-(3-trifluoromethyl-phenyl)-but-3-enoic acid

A

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

B

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
With edetate disodium; thiamine diphosphate; sodium citrate; magnesium chloride In water; acetonitrile at 20℃; Rate constant; pH 6.0, brewers' yeast pyruvate decarboxylase (PDC, EC 4.1.1.1), also in the presence of pyruvamide;
3-<2-chloro-ethyl>-trifluoromethyl-benzene

3-<2-chloro-ethyl>-trifluoromethyl-benzene

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

Conditions
ConditionsYield
With carbon dioxide; magnesium
m-trifluoromethyl-α-chlorohydrocinnamic acid

m-trifluoromethyl-α-chlorohydrocinnamic acid

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

Conditions
ConditionsYield
Stage #1: m-trifluoromethyl-α-chlorohydrocinnamic acid With acetic acid; zinc In water at 20 - 35℃; for 1h;
Stage #2: With hydrogenchloride In water at 20℃; Product distribution / selectivity;
methyl 3-(3-(trifluoromethyl)phenyl)propanoate
294856-02-3

methyl 3-(3-(trifluoromethyl)phenyl)propanoate

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

Conditions
ConditionsYield
Stage #1: methyl 3-(3-(trifluoromethyl)phenyl)propanoate With sodium hydroxide; isopropyl alcohol at 20℃; for 6h;
Stage #2: With hydrogenchloride; water
Stage #1: methyl 3-(3-(trifluoromethyl)phenyl)propanoate With lithium hydroxide monohydrate In tetrahydrofuran; water at 20℃; for 48h;
Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether; water
With water; sodium hydroxide In methanol at 20℃; for 4h;3.9 g
3-Trifluoromethylbenzaldehyde
454-89-7

3-Trifluoromethylbenzaldehyde

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: piperidine / pyridine / 50 - 75 °C / Inert atmosphere
1.2: 0 °C / Cooling with ice
2.1: hydrogen / palladium 10% on activated carbon / methanol / 2.5 h / 750.08 Torr
View Scheme
Multi-step reaction with 2 steps
1.1: pyridine; piperidine / 4.25 h / 20 - 120 °C / Inert atmosphere
1.2: pH 2
2.1: sodium hydroxide / water / 20 °C
2.2: 7 h / 25 - 30 °C / 750.08 Torr
2.3: pH 2
View Scheme
3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: palladium diacetate; potassium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 15 h / 110 °C / Inert atmosphere
1.2: 15 h / 20 °C / 760.05 Torr
2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 48 h / 20 °C
View Scheme
3-Trifluoromethylbenzyl chloride
705-29-3

3-Trifluoromethylbenzyl chloride

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 5 °C
1.2: 2 h
2.1: sodium chloride / water; N,N-dimethyl-formamide / 6 h / 150 °C
3.1: sodium hydroxide; water / methanol / 4 h / 20 °C
View Scheme
dimethyl 2-(3-(trifluoromethyl)benzyl)malonate

dimethyl 2-(3-(trifluoromethyl)benzyl)malonate

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium chloride / water; N,N-dimethyl-formamide / 6 h / 150 °C
2: sodium hydroxide; water / methanol / 4 h / 20 °C
View Scheme
methanol
67-56-1

methanol

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

methyl 3-(3-(trifluoromethyl)phenyl)propanoate
294856-02-3

methyl 3-(3-(trifluoromethyl)phenyl)propanoate

Conditions
ConditionsYield
With sulfuric acid Reflux;99%
With thionyl chloride for 4h; Inert atmosphere; Reflux;97%
With sulfuric acid at 30 - 45℃;
2-Amino-5-(4-methyl-phenyl)-thiophene-3-carboxylic Acid Amide

2-Amino-5-(4-methyl-phenyl)-thiophene-3-carboxylic Acid Amide

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

C22H17F3N2OS
1393911-92-6

C22H17F3N2OS

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In chloroform at 120℃; Microwave irradiation;98%
3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

(R)-<1-(1-Naphthyl)ethyl>ammonium chloride
82572-04-1

(R)-<1-(1-Naphthyl)ethyl>ammonium chloride

(R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide
1005450-55-4

(R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide

Conditions
ConditionsYield
Stage #1: (R)-<1-(1-Naphthyl)ethyl>ammonium chloride With sodium hydroxide In toluene
Stage #2: 3-(3-trifluoromethylphenyl)propanoic acid In toluene at 140 - 150℃; Further stages.;
95%
3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

3-[3-(trifluoromethyl)phenyl]propan-1-ol
78573-45-2

3-[3-(trifluoromethyl)phenyl]propan-1-ol

Conditions
ConditionsYield
Stage #1: 3-(3-trifluoromethylphenyl)propanoic acid With borane-THF In tetrahydrofuran at 0 - 20℃; for 25h;
Stage #2: With water In tetrahydrofuran; methanol
94%
With borane In tetrahydrofuran at 0 - 20℃; for 25h; Inert atmosphere;94%
Stage #1: 3-(3-trifluoromethylphenyl)propanoic acid With 4-methyl-morpholine; chloroformic acid ethyl ester In 2-methyltetrahydrofuran at -10 - -5℃; for 0.00166667h;
Stage #2: With sodium tetrahydroborate In 2-methyltetrahydrofuran; water at 0 - 5℃; for 0.5h; Solvent; Reagent/catalyst;
92.2%
3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

3-(trifluoromethyl)benzenepropanoic acid chloride
455-03-8

3-(trifluoromethyl)benzenepropanoic acid chloride

Conditions
ConditionsYield
With thionyl chloride; N,N-dimethyl-formamide In Isopropyl acetate at 43℃; Temperature;93%
With thionyl chloride
With thionyl chloride In toluene for 2h; Heating;
(R)-1-(1-Naphthyl)ethylamine
3886-70-2

(R)-1-(1-Naphthyl)ethylamine

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

cinacalcet
226256-56-0

cinacalcet

Conditions
ConditionsYield
With tris(pentafluorophenyl)borate; phenylsilane In dibutyl ether at 120℃; for 24h; Solvent; Reagent/catalyst; Concentration; Inert atmosphere; Schlenk technique;89%
With tris(pentafluorophenyl)borate; phenylsilane In dibutyl ether at 120℃; for 20h; Schlenk technique; Inert atmosphere;87%
With potassium phosphate; 18-crown-6 ether; phenylsilane In tetrahydrofuran at 80℃; for 36h; Glovebox; Molecular sieve; Schlenk technique;
(S)-2-(p-tolylsulfinyl)aniline

(S)-2-(p-tolylsulfinyl)aniline

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

(S)-3-(3-trifluoromethylphenyl)-N-(2-(p-tolylsulfinyl)phenyl)propanamide

(S)-3-(3-trifluoromethylphenyl)-N-(2-(p-tolylsulfinyl)phenyl)propanamide

Conditions
ConditionsYield
With dmap; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h;86%
(R)-1-(1-Naphthyl)ethylamine
3886-70-2

(R)-1-(1-Naphthyl)ethylamine

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

(R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide
1005450-55-4

(R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 15h; Inert atmosphere;83%
Stage #1: 3-(3-trifluoromethylphenyl)propanoic acid With 1,1'-carbonyldiimidazole In dichloromethane for 1h;
Stage #2: (R)-1-(1-Naphthyl)ethylamine In dichloromethane at 25 - 35℃; Solvent; Temperature;
82.94%
Stage #1: 3-(3-trifluoromethylphenyl)propanoic acid With thionyl chloride; N,N-dimethyl-formamide In toluene at 25 - 75℃; for 2h;
Stage #2: (R)-1-(1-Naphthyl)ethylamine With triethylamine In dichloromethane; toluene at 0 - 5℃; for 1.5 - 2h;
70.87%
3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

diisopropylamine
108-18-9

diisopropylamine

C16H22F3NO

C16H22F3NO

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 12h;79%
3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

3-[3-(trifluoromethyl)phenyl]propanal
21172-41-8

3-[3-(trifluoromethyl)phenyl]propanal

Conditions
ConditionsYield
With succinic acid anhydride; 4,4'-dibromo-2,2'-bipyridine; diphenylsilane; nickel(II) hydroxide In tetrahydrofuran at 70℃; for 10h; Schlenk technique; Inert atmosphere;75%
Multi-step reaction with 2 steps
1: 85 percent / LAH
2: 65 percent / (COCl)2/DMSO; Et3N
View Scheme
Multi-step reaction with 2 steps
1.1: sulfuric acid / 30 - 45 °C
2.1: diisobutylaluminium hydride / toluene; hexane / 2.5 h / -80 - -78 °C
2.2: -80 - -78 °C
View Scheme
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere; Schlenk technique
2: Dess-Martin periodane / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Schlenk technique
View Scheme
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
(R)-1-(1-Naphthyl)ethylamine
3886-70-2

(R)-1-(1-Naphthyl)ethylamine

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

cinacalcet hydrochloride
364782-34-3

cinacalcet hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-1-(1-Naphthyl)ethylamine; 3-(3-trifluoromethylphenyl)propanoic acid With platinum(0)-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex; phenylsilane; 1,2-bis-(diphenylphosphino)ethane In dibutyl ether at 120℃; for 18h; Schlenk technique; Inert atmosphere;
Stage #2: With hydrogenchloride In diethyl ether at -20℃; Schlenk technique; Inert atmosphere;
74%
2-methyl-1H-indole
95-20-5

2-methyl-1H-indole

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

C19H18F3N

C19H18F3N

Conditions
ConditionsYield
With aluminium(III) triflate; Co(acac)3; hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] at 140℃; under 22502.3 Torr; for 18h; Autoclave; Sealed tube;72%
3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

aniline
62-53-3

aniline

N-(3-(3-(trifluoromethyl)phenyl)propyl)aniline

N-(3-(3-(trifluoromethyl)phenyl)propyl)aniline

Conditions
ConditionsYield
With cobalt(II) tetrafluoroborate hexahydrate; (p-anisyl)triphos; hydrogen In 1,4-dioxane at 140℃; under 30003 Torr; for 24h; Autoclave; Green chemistry;69%
Succinimide
123-56-8

Succinimide

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

3-(3-trifluoromethylphenyl)propanoyl succinimide

3-(3-trifluoromethylphenyl)propanoyl succinimide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 18h; Inert atmosphere;53%
Stage #1: 3-(3-trifluoromethylphenyl)propanoic acid With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran for 0.5h; Inert atmosphere;
Stage #2: Succinimide In tetrahydrofuran for 48h;
44%
3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

N-(6-(3-amino-4-fluorophenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide

N-(6-(3-amino-4-fluorophenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide

N-(6-(4-fluoro-3-(3-(3-(trifluoromethyl)phenyl)propionylamino)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide

N-(6-(4-fluoro-3-(3-(3-(trifluoromethyl)phenyl)propionylamino)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide

Conditions
ConditionsYield
With HATU In pyridine at 85℃; for 8h; Inert atmosphere;39%
2-amino-1-(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethanone
1020656-57-8

2-amino-1-(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethanone

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

N-(2-oxo-2-(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide
1020656-11-4

N-(2-oxo-2-(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide

Conditions
ConditionsYield
Stage #1: 3-(3-trifluoromethylphenyl)propanoic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1h;
Stage #2: 2-amino-1-(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethanone In dichloromethane at 20℃; for 16h;
38%
3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

3-[3-(trifluoromethyl)cyclohexyl]propanoic acid
329-02-2

3-[3-(trifluoromethyl)cyclohexyl]propanoic acid

Conditions
ConditionsYield
With acetic acid; platinum Hydrogenation;
3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

methyl 3-(3-(trifluoromethyl)phenyl)propanoate
294856-02-3

methyl 3-(3-(trifluoromethyl)phenyl)propanoate

Conditions
ConditionsYield
With methanol Esterification;
4-{2-[(1S)-((S)-tert-butanesulfinylamino)-3-methylbutyl]-4-(trifluoromethyl)phenyl}-1-piperazine
851484-80-5

4-{2-[(1S)-((S)-tert-butanesulfinylamino)-3-methylbutyl]-4-(trifluoromethyl)phenyl}-1-piperazine

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

2-Methyl-propane-2-sulfinic acid [(S)-3-methyl-1-(5-trifluoromethyl-2-{4-[3-(3-trifluoromethyl-phenyl)-propionyl]-piperazin-1-yl}-phenyl)-butyl]-amide

2-Methyl-propane-2-sulfinic acid [(S)-3-methyl-1-(5-trifluoromethyl-2-{4-[3-(3-trifluoromethyl-phenyl)-propionyl]-piperazin-1-yl}-phenyl)-butyl]-amide

Conditions
ConditionsYield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane; N,N-dimethyl-formamide
3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

[(S)-1-(7,8-Dihydro-naphthalen-1-yl)-ethyl]-[3-(3-trifluoromethyl-phenyl)-propyl]-amine

[(S)-1-(7,8-Dihydro-naphthalen-1-yl)-ethyl]-[3-(3-trifluoromethyl-phenyl)-propyl]-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 85 percent / LAH
2: 65 percent / (COCl)2/DMSO; Et3N
View Scheme
3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

[(R)-1-(7,8-Dihydro-naphthalen-1-yl)-ethyl]-[3-(3-trifluoromethyl-phenyl)-propyl]-amine

[(R)-1-(7,8-Dihydro-naphthalen-1-yl)-ethyl]-[3-(3-trifluoromethyl-phenyl)-propyl]-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 85 percent / LAH
2: 65 percent / (COCl)2/DMSO; Et3N
View Scheme
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