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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(E)-3-(3-(TRIFLUOROMETHYL)PHENYL)ACRYLALDEHYDE

Cas:262268-58-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

3-(Trifluoromethyl)cinnamaldehyde

Cas:262268-58-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3-(trifluoromethyl) Cinnamaldehyde CAS:262268-58-6

Cas:262268-58-6

Min.Order:1 Kilogram

FOB Price: $5.0 / 20.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

3-(trifluoromethyl) Cinnamaldehyde CAS:262268-58-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali

3-(trifluoromethyl) Cinnamaldehyde CAS:262268-58-6

Cas:262268-58-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Propenal,3-[3-(trifluoromethyl)phenyl]-, (2E)-

Cas:262268-58-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3-(Trifluoromethyl)cinnamaldehyde

Cas:262268-58-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

3-(Trifluoromethyl)cinnamaldehyde

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

3-(trifluoromethyl) Cinnamaldehyde

Cas:262268-58-6

Min.Order:1 Kilogram

Negotiable

Type:Other

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3-Trifluoromethyl Cinnamaldehyde cas no. 262268-58-6 98%

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

(2E)-3-[3-(trifluoromethyl)phenyl]prop-2-enal

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

2-Propenal,3-[3-(trifluoromethyl)phenyl]-, (2E)-

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

3-(trifluoromethyl) Cinnamaldehyde

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2-Propenal,3-[3-(trifluoromethyl)phenyl]-, (2E)-

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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DB BIOTECH CO., LTD

best seller Application:API

3-(trifluoromethyl) Cinnamaldehyde

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

3-(trifluoromethyl) CinnamaldehydeAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

3-(trifluoromethyl) Cinnamaldehyde

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-(trifluoromethyl) Cinnamaldehyde

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

262268-58-6

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei Muhuang Technology Co., Ltd

best seller Application:API

3-(trifluoromethyl) Cinnamaldehyde

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

3-(trifluoromethyl) Cinnamaldehyde

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers.Appearance:White powder Storage:keep sealed and keep from direct light Package:According client's requirements Application:pharmaceutica

3-(trifluoromethyl) Cinnamaldehyde manufacturer

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-(trifluoromethyl) Cinnamaldehyde

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

3-(Trifluoromethyl)cinnamaldehyde

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

(E)-3-(3-(Trifluoromethyl)phenyl)acrylaldehyde

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Other

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

3-(Trifluoromethyl)cinnamaldehyde

Cas:262268-58-6

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Changzhou Extraordinary Pharmatech co.,LTD

Changzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa

trans 3-trifluoromethyl cinnamaldehyde

Cas:262268-58-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

(E)-3-(3-(TRIFLUOROMETHYL)PHENYL)ACRYLALDEHYDE CAS NO.262268-58-6

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

suzhou BetterBioChem Co., Ltd.

Betterbiochem is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in

3-(TRIFLUOROMETHYL) CINNAMALDEHYDE;(2E)-3-[3-(TRIFLUOROMETHYL)PHENYL]PROP-2-ENAL

Cas:262268-58-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

HuBei Ipure Biotech CO.,ltd

HuBei ipure is a diversified product production and operation enterprise, with API, pharma intermediates, and other fine chemicals as well as R&D and pigments development and sales as one of the large enterprises, with more than 130 acres of pl

3-(Trifluoromethyl)cinnamaldehyde CAS: 262268-58-6 in stock

Cas:262268-58-6

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Nanjing Chemlin Chemical Co., Ltd.

Compound sourcing ServicesAgency of testing serviceFactory audit serviceFounded in Dec. 1999, Nanjing Chemlin Chemical Industrial Co.,Ltd(CHEMLIN) has been covering the business scope from trading of chemicals to custom-synthesis & Manufacturing. Co

262268-58-6

Cas:262268-58-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

AOPHARM

Aopharm is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in modes of tran

3-(trifluoromethyl) Cinnamaldehyde

Cas:262268-58-6

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Synthetic route

3-Trifluoromethylbenzaldehyde
454-89-7

3-Trifluoromethylbenzaldehyde

acetaldehyde
75-07-0

acetaldehyde

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20 - 25℃; for 48h; Reagent/catalyst; Solvent;75%
1-(3-Trifluoromethyl-phenyl)-prop-2-yn-1-ol

1-(3-Trifluoromethyl-phenyl)-prop-2-yn-1-ol

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
With methyl trifluoromethanesulfonate In 2,2,2-trifluoroethanol at 70℃; for 1h;68%
With toluene-4-sulfonic acid In 1,2-dichloro-ethane at 60℃; for 5h; Meyer-Schuster Rearrangement; stereoselective reaction;50%
3-Trifluoromethylbenzaldehyde
454-89-7

3-Trifluoromethylbenzaldehyde

formylmethyltriphenylphosphonium chloride
62942-43-2

formylmethyltriphenylphosphonium chloride

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 48h;30%
(E)-2-Oxo-4-(3-trifluoromethyl-phenyl)-but-3-enoic acid

(E)-2-Oxo-4-(3-trifluoromethyl-phenyl)-but-3-enoic acid

A

3-(3-trifluoromethylphenyl)propanoic acid
585-50-2

3-(3-trifluoromethylphenyl)propanoic acid

B

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
With edetate disodium; thiamine diphosphate; sodium citrate; magnesium chloride In water; acetonitrile at 20℃; Rate constant; pH 6.0, brewers' yeast pyruvate decarboxylase (PDC, EC 4.1.1.1), also in the presence of pyruvamide;
(E)-3-(3-trifluoromethylphenyl)prop-2-en-1-ol
113048-69-4

(E)-3-(3-trifluoromethylphenyl)prop-2-en-1-ol

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
With manganese(IV) oxide In dichloromethane at 20℃; for 2h; Oxidation;
With dipyridinium dichromate In N,N-dimethyl-formamide at 20℃; for 1.5h;
With manganese(IV) oxide In hexane; ethyl acetate at 20℃; Inert atmosphere;
acrylaldehyde diethyl acetal
3054-95-3

acrylaldehyde diethyl acetal

m-trifluoromethylphenyl iodide
401-81-0

m-trifluoromethylphenyl iodide

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
Stage #1: acrylaldehyde diethyl acetal; m-trifluoromethylphenyl iodide With potassium chloride; tetrabutylammonium acetate; palladium diacetate; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 2h; Heck Reaction;
Stage #2: With hydrogenchloride In water
3-Trifluoromethylbenzaldehyde
454-89-7

3-Trifluoromethylbenzaldehyde

(triphenylphosphoranylidene)acetaldehyde
2136-75-6

(triphenylphosphoranylidene)acetaldehyde

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

1-((E)-3,3-Diethoxy-propenyl)-3-trifluoromethyl-benzene

1-((E)-3,3-Diethoxy-propenyl)-3-trifluoromethyl-benzene

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
With hydrogenchloride In N,N-dimethyl-formamide at 20℃; for 0.166667h;
With hydrogenchloride In water at 20℃; for 3h; Product distribution / selectivity;
acrylaldehyde diethyl acetal
3054-95-3

acrylaldehyde diethyl acetal

3-F3CC6H4-Hal

3-F3CC6H4-Hal

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
Stage #1: acrylaldehyde diethyl acetal; 3-F3CC6H4-Hal With potassium chloride; tetrabutylammonium acetate; potassium carbonate; palladium diacetate In N,N-dimethyl-formamide at 90℃; for 1.5h;
Stage #2: With hydrogenchloride at 20℃; for 0.166667h;
3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: n-Bu4NOAc; K2CO3; KCl / Pd(OAc)2 / dimethylformamide / 2 h / 90 °C
2: aq. HCl / dimethylformamide / 0.17 h / 20 °C
View Scheme
m-trifluoromethylphenyl iodide
401-81-0

m-trifluoromethylphenyl iodide

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: n-Bu4NOAc; K2CO3; KCl / Pd(OAc)2 / dimethylformamide / 3.5 h / 90 °C
2: aq. HCl / dimethylformamide / 0.17 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate; tetrabutylammonium acetate; palladium diacetate; potassium chloride / N,N-dimethyl-formamide / 4 h / 90 °C
2: hydrogenchloride / N,N-dimethyl-formamide; water / 2 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate; potassium chloride; palladium diacetate; triphenylphosphine / tetrahydrofuran / 4 h / 60 °C
2: hydrogenchloride; water / 2 h / 20 °C
View Scheme
3-(trifluoromethyl)cinnamic acid
779-89-5

3-(trifluoromethyl)cinnamic acid

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: K2CO3 / acetone / Heating
2: DIBAL / 1 h / 0 °C
3: PDC / dimethylformamide / 1.5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: thionyl chloride / methanol / 2 h / 65 °C
1.2: 2.5 h / -50 °C / Inert atmosphere
2.1: manganese(IV) oxide / hexane; ethyl acetate / 20 °C / Inert atmosphere
View Scheme
trans-methyl 3-(3-(trifluoromethyl)phenyl)acrylate
104201-66-3

trans-methyl 3-(3-(trifluoromethyl)phenyl)acrylate

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: DIBAL / 1 h / 0 °C
2: PDC / dimethylformamide / 1.5 h / 20 °C
View Scheme
3-Trifluoromethylbenzaldehyde
454-89-7

3-Trifluoromethylbenzaldehyde

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: NaH / 1,2-dimethoxy-ethane / 0.25 h / 0 °C
1.2: 1,2-dimethoxy-ethane / 0.25 h / 0 °C
2.1: DIBAL / toluene / 0.33 h / 0 °C
3.1: MnO2 / CH2Cl2 / 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: pyridine; piperidine / 100 °C
2.1: thionyl chloride / methanol / 2 h / 65 °C
2.2: 2.5 h / -50 °C / Inert atmosphere
3.1: manganese(IV) oxide / hexane; ethyl acetate / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
2: toluene-4-sulfonic acid / 1,2-dichloro-ethane / 5 h / 60 °C
View Scheme
(E)-ethyl 3-(3-trifluoromethylphenyl)prop-2-enoate
116577-12-9, 113048-68-3

(E)-ethyl 3-(3-trifluoromethylphenyl)prop-2-enoate

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: DIBAL / toluene / 0.33 h / 0 °C
2: MnO2 / CH2Cl2 / 2 h / 20 °C
View Scheme
3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

acrylaldehyde diethyl acetal
3054-95-3

acrylaldehyde diethyl acetal

A

ethyl 3-(3-trifluoromethylphenyl)-propionate
70311-33-0

ethyl 3-(3-trifluoromethylphenyl)-propionate

B

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
Stage #1: 3-bromo-1-trifluoromethylbenzene; acrylaldehyde diethyl acetal With potassium carbonate; 5%-palladium/activated carbon In N,N-dimethyl-formamide at 125 - 130℃; for 5.25h; Heck Reaction;
Stage #2: With hydrogenchloride In water at 20℃; for 0.333333 - 1h; Product distribution / selectivity;
C12H13F3O2

C12H13F3O2

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
With hydrogenchloride In water; N,N-dimethyl-formamide at 20℃; for 2h;
C12H13F3O2

C12H13F3O2

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

Conditions
ConditionsYield
With hydrogenchloride; water at 20℃; for 2h;
(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde-2-d

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde-2-d

Conditions
ConditionsYield
With deuteroacetic acid; water-d2; isopropylamine at 100℃; for 14h; regioselective reaction;96%
(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

(E)-3-(3-trifluoromethylphenyl)prop-2-en-1-ol
113048-69-4

(E)-3-(3-trifluoromethylphenyl)prop-2-en-1-ol

Conditions
ConditionsYield
With C46H49CoN3P4(2+)*2BF4(1-); hydrogen; potassium hydroxide In ethanol; acetonitrile at 60℃; under 22801.5 Torr; for 24h; Autoclave; Glovebox; chemoselective reaction;91%
With sodium tetrahydroborate In methanol at 0 - 20℃; for 1h;
With sodium tetrahydroborate In methanol at 0 - 20℃; for 0.5h;
With sodium tetrahydroborate In methanol at 0℃; for 0.5h;
With sodium tetrahydroborate In methanol at 0 - 20℃; for 1h;
3-Methyl-3-sulfanylbutan-1-ol
34300-94-2

3-Methyl-3-sulfanylbutan-1-ol

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

trans-4,4-dimethyl-2-(m-trifluoromethylstyryl)-1,3-oxathiane
561329-03-1

trans-4,4-dimethyl-2-(m-trifluoromethylstyryl)-1,3-oxathiane

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 1.16667h;85%
(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

bromomethanesulfonyl fluoride

bromomethanesulfonyl fluoride

(1Z,3E)-1-bromo-4-(3-(trifluoromethyl)phenyl)buta-1,3-diene-1-sulfonyl fluoride

(1Z,3E)-1-bromo-4-(3-(trifluoromethyl)phenyl)buta-1,3-diene-1-sulfonyl fluoride

Conditions
ConditionsYield
Stage #1: (E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde With pyrrolidine In tetrahydrofuran for 0.0833333h; Knoevenagel Condensation;
Stage #2: bromomethanesulfonyl fluoride In tetrahydrofuran at 20℃; for 0.333333h; stereoselective reaction;
69%
allyl alcohol
107-18-6

allyl alcohol

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

3-(3-trifluoromethyl-phenyl)-propionic acid allyl ester

3-(3-trifluoromethyl-phenyl)-propionic acid allyl ester

Conditions
ConditionsYield
With triethylamine; 2-hydroxy-2-methylpropanenitrile at 25℃; for 3h;66%
iodomethanesulfonyl fluoride
1426-04-6

iodomethanesulfonyl fluoride

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

(1Z,3E)-1-iodo-4-(3-(trifluoromethyl)phenyl)buta-1,3-diene-1-sulfonyl fluoride

(1Z,3E)-1-iodo-4-(3-(trifluoromethyl)phenyl)buta-1,3-diene-1-sulfonyl fluoride

Conditions
ConditionsYield
Stage #1: (E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde With pyrrolidine In tetrahydrofuran for 0.0833333h; Knoevenagel Condensation;
Stage #2: iodomethanesulfonyl fluoride In tetrahydrofuran at 20℃; for 0.333333h; stereoselective reaction;
64%
tert-butyl (2-nitroethyl)carbamate

tert-butyl (2-nitroethyl)carbamate

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

tert-butyl (3S,4S)-3-nitro-4-(3-(trifluoromethyl)phenyl)-3,4-dihydropyridine-1(2H)-carboxylate

tert-butyl (3S,4S)-3-nitro-4-(3-(trifluoromethyl)phenyl)-3,4-dihydropyridine-1(2H)-carboxylate

Conditions
ConditionsYield
Stage #1: tert-butyl-(2-nitroethyl)carbamate; (E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; benzoic acid In dichloromethane at 0 - 20℃;
Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 5h;
63%
(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

(2R,3R)-2-(2,4-difluorophenyl)-3-[[2-hydroxy-1-(hydroxymethyl)ethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol
183800-60-4

(2R,3R)-2-(2,4-difluorophenyl)-3-[[2-hydroxy-1-(hydroxymethyl)ethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol

(2R,3R)-2-(2,4-Difluoro-phenyl)-1-[1,2,4]triazol-1-yl-3-{2-[(E)-2-(3-trifluoromethyl-phenyl)-vinyl]-[1,3]dioxan-5-ylsulfanyl}-butan-2-ol

(2R,3R)-2-(2,4-Difluoro-phenyl)-1-[1,2,4]triazol-1-yl-3-{2-[(E)-2-(3-trifluoromethyl-phenyl)-vinyl]-[1,3]dioxan-5-ylsulfanyl}-butan-2-ol

Conditions
ConditionsYield
With 4 A molecular sieve; toluene-4-sulfonic acid In dichloromethane at 20℃; for 4h; Condensation;57%
(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

acetone
67-64-1

acetone

(3E,5E)-6-(3-(trifluoromethyl)phenyl)hexa-3,5-dien-2-one

(3E,5E)-6-(3-(trifluoromethyl)phenyl)hexa-3,5-dien-2-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; Schlenk technique; Inert atmosphere;56%
chloromethanesulfonyl fluoride
373-93-3

chloromethanesulfonyl fluoride

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

(1Z,3E)-1-chloro-4-(3-(trifluoromethyl)phenyl)buta-1,3-diene-1-sulfonyl fluoride

(1Z,3E)-1-chloro-4-(3-(trifluoromethyl)phenyl)buta-1,3-diene-1-sulfonyl fluoride

Conditions
ConditionsYield
Stage #1: (E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde With pyrrolidine In tetrahydrofuran for 0.0833333h; Knoevenagel Condensation;
Stage #2: chloromethanesulfonyl fluoride In tetrahydrofuran at 20℃; for 0.333333h; stereoselective reaction;
56%
2-oxo-propionic acid
127-17-3

2-oxo-propionic acid

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

glycine
56-40-6

glycine

(2R,3S,4R,5S)-3-Formyl-2-methyl-4-(3-trifluoromethyl-phenyl)-pyrrolidine-2,5-dicarboxylic acid

(2R,3S,4R,5S)-3-Formyl-2-methyl-4-(3-trifluoromethyl-phenyl)-pyrrolidine-2,5-dicarboxylic acid

Conditions
ConditionsYield
Stage #1: 2-oxo-propionic acid; glycine With copper diacetate Condensation; Complexation;
Stage #2: (E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde With sodium hydroxide In methanol pH=9.5; Cyclocondensation;
55%
toluene-4-sulfonamide
70-55-3

toluene-4-sulfonamide

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

(E)-4-methyl-N-((E)-3-(3-(trifluoromethyl)phenyl)allylidene)benzenesulfonamide

(E)-4-methyl-N-((E)-3-(3-(trifluoromethyl)phenyl)allylidene)benzenesulfonamide

Conditions
ConditionsYield
With tetraethoxy orthosilicate at 160℃; Dean-Stark;52%
Methyltriphenylphosphonium bromide
1779-49-3

Methyltriphenylphosphonium bromide

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

(E)-1-(buta-1,3-dien-1-yl)-3-(trifluoromethyl)benzene
98451-42-4

(E)-1-(buta-1,3-dien-1-yl)-3-(trifluoromethyl)benzene

Conditions
ConditionsYield
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 0.333333h; Inert atmosphere;
Stage #2: (E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde In tetrahydrofuran; hexane at 20℃; Inert atmosphere;
51%
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1.5h; Inert atmosphere;
Stage #2: (E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde In tetrahydrofuran; hexane at 0 - 20℃; for 1h; Wittig Olefination; Inert atmosphere;
allyltriphenylphosphonium bromide
1560-54-9

allyltriphenylphosphonium bromide

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

C13H11F3

C13H11F3

Conditions
ConditionsYield
Stage #1: allyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran; hexane at 0 - 20℃; for 0.5h; Wittig Olefination; Inert atmosphere;
Stage #2: (E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde In tetrahydrofuran; hexane at 0℃; for 3h; Wittig Olefination; Inert atmosphere;
51%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

ethyl (2E,4E)-5-(3-trifluoromethylphenyl)penta-2,4-dienoate

ethyl (2E,4E)-5-(3-trifluoromethylphenyl)penta-2,4-dienoate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran; mineral oil for 0.166667h; Cooling with ice;
Stage #2: (E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde In tetrahydrofuran; mineral oil for 0.25h; Cooling with ice;
49%
trimethylsulphonium iodide
2181-42-2

trimethylsulphonium iodide

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

(E)-2-(3-(trifluoromethyl)styryl)oxirane

(E)-2-(3-(trifluoromethyl)styryl)oxirane

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; dimethyl sulfoxide; mineral oil at 0 - 20℃; for 12.5h; Inert atmosphere;43%
(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

(E)-2-[2-(Dimethoxy-phosphorylmethyl)-phenyl]-3-methoxy-acrylic acid methyl ester

(E)-2-[2-(Dimethoxy-phosphorylmethyl)-phenyl]-3-methoxy-acrylic acid methyl ester

(E)-3-Methoxy-2-{2-[(1E,3E)-4-(3-trifluoromethyl-phenyl)-buta-1,3-dienyl]-phenyl}-acrylic acid methyl ester

(E)-3-Methoxy-2-{2-[(1E,3E)-4-(3-trifluoromethyl-phenyl)-buta-1,3-dienyl]-phenyl}-acrylic acid methyl ester

Conditions
ConditionsYield
Stage #1: (E)-2-[2-(Dimethoxy-phosphorylmethyl)-phenyl]-3-methoxy-acrylic acid methyl ester With sodium hydride In tetrahydrofuran at 20℃; for 0.333333h; Metallation;
Stage #2: (E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde In tetrahydrofuran for 2h; Condensation; Wittig-Horner reaction; Heating; Further stages.;
(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

O,O-Diethyl 3-Trifluoromethylphenylmethylphosphonate
146780-08-7

O,O-Diethyl 3-Trifluoromethylphenylmethylphosphonate

E,E-1,4-di(m-trifluoromethyl)phenyl-1,3-butadiene
847186-64-5

E,E-1,4-di(m-trifluoromethyl)phenyl-1,3-butadiene

Conditions
ConditionsYield
With sodium hydride Horner-Wadsworth-Emmons olefination;
sodium trichloroacetate
650-51-1

sodium trichloroacetate

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

(E)-1,1,1-Trichloro-4-(3-trifluoromethyl-phenyl)-but-3-en-2-ol
351536-42-0

(E)-1,1,1-Trichloro-4-(3-trifluoromethyl-phenyl)-but-3-en-2-ol

Conditions
ConditionsYield
With trichloroacetic acid In N,N-dimethyl-formamide at 20℃;
(E)-4-methoxy-N-((E)-p-tolylethylidene)benzenesulfonamide
861145-19-9

(E)-4-methoxy-N-((E)-p-tolylethylidene)benzenesulfonamide

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

trans-1-(4-methoxyphenylsulfonyl)-5-p-tolyl-4-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one

trans-1-(4-methoxyphenylsulfonyl)-5-p-tolyl-4-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one

cis-1-(4-methoxyphenylsulfonyl)-5-p-tolyl-4-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one

cis-1-(4-methoxyphenylsulfonyl)-5-p-tolyl-4-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3-bis(mesityl)imidazolium chloride In tert-butyl alcohol at 60℃; for 4h; Title compound not separated from byproducts;
(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde
262268-58-6

(E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde

C36H24F12

C36H24F12

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaH
2: 15 h / 25 °C / UV-irradiation
View Scheme

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