Consumption of foods rich in dietary antioxidants and anti-inflammatory compounds is becoming a key strategy to lower oxidative stress and inflammation. The objective of this work was to study the effect of fermentation and starter culture on ascorbigen (ABG) and vitamin C content, as well as an...

In addition to sawaranin previously reported, five new decarboxylated ascorbigens, 4-epi-sawaranin and sawaranospirolides A–D, have been isolated from the heartwood of Chamaecyparis pisifera, and their structures determined by spectral and chemical methods. A nor-lignan, agatharesinol, was also...

The structure of sawaranin which had been isolated from the heartwood of Chamaecyparis pisifera was reexamined. The structure as a decarboxylated ascorbigen, (3S,4R,6R,7S)-5,8-epoxy-3-p-hydroxyphenyl-5,6,7-trihydroxyoctan-1,4-olide, was determined by spectral analyses of sawaranin and its deriva...

The effect of processing of vegetables on ascorbigen formation, the ultimate fate of its transformation, their pharmacological evaluation are areas requiring detailed study using analytical methods capable of measuring various individual components. A reversed-phase chromatographic system for se...

The formation of 5,11-dihydroindolo[3,2-b]carbazole, a polyaromatic hydrocarbon responsiveness-receptor agonist as well as an anti-initiator and promoter of carcinogenesis, from ascorbigen under conditions of chemical synthesis and during incubation with gastric juice at physiological conditions...

Ascorbigen, one of the most important indole derivatives of Brassica vegetables, is formed by an enzymatic degradation of indole glucosinolate glucobrassicin followed by a subsequent spontaneous reaction between indole-3-carbinol and l-ascorbic acid. Experiments, carried out in model solutions s...

New methods of l-ascorbic acid derivatization with the use of polyfunctional indole-3-cabinols are described. Reaction of β-hydroxy-N-methyltryptamine and l-ascorbic acid gave lactame derivatives; (indol-3-yl)glycolic and l-ascorbic acids produced 2-hydroxy-4-hydroxymethyl-3-(indol-3-yl)-cyclop...

Ascorbigen (ABG) belongs to the glucosinolate family and occurs mainly in Brassica vegetables. It is formed by its precursor glucobrassicin. Glucobrassicin is enzymatically hydrolyzed to indole-3-carbinol, which in turn reacts with l-ascorbic acid to ABG. The degradation of glucobrassicin is ind...

Sodium arsenite at a non-toxic concentration was found to inhibit strongly mutagenesis induced by ultraviolet light (UV), 4-nitroquinoline-1-oxide (4NQO), furylfuramide (AF-2) and methyl methanesulfonate (MMS) as well as spontaneous mutation in the reversion assay of E. coli WP2uvrA/pKM101. The ...

Ligands may increase the yields of reactive oxygen species (ROS) in zero-valent iron (ZVI)/O2 systems. To clarify the relationship between the properties of ligands and their effects on the oxidative removal of contaminants, five common ligands (formate, acetate, oxalate, ethylenediaminetetraace...

A signal-on aptasensor was fabricated for highly sensitive and selective electrochemical detection of arsenite with a label-free Ars-3 aptamer self-assembled on a screen-printed carbon electrode (SPCE) via Au–S bond. The Ars-3 aptamer could adsorb cationic polydiallyldimethylammonium (PDDA) via...

Three new salen-type copper (II) and nickel (II) complexes viz. [Cu(L)2] (1); [Ni(L)2] (2); [Ni(L1) (DMF)] (3), where HL = 2-((E)-(4-bromo-2-chlorophenylimino) methyl)-6-bromo-4-nitrophenol and HL1= (E)-1-(3,5-dichloro-2-hydroxybenzylidene)-4,4-dimethylthiosemicarbazide; DMF = N, N-dimethylforma...

As a vital byproduct of chemical intermediates for pesticides and cytotoxin inhibitors, 2-bromo-4-nitrophenol (2B4NP) is toxic to aquatic life. However, bacterial cultures mineralizing 2B4NP have not been reported. In this study, Cupriavidus sp. strain NyZ375 was isolated from aromatics-polluted...

A simple and efficient Knoevenagel procedure for the synthesis of 2-arylidene indan-1,3-diones is herein reported. These compounds were prepared via ZrOCl2·8H2O catalyzed reactions of indan-1,3-dione with several aromatic aldehydes and using water as the solvent. The 2-arylidene indan-1,3-dione...

A series of 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine derivatives (7a–q, 10a–q) were designed, synthesized and their chemical structures were confirmed by 1H NMR, 13C NMR, MS and HRMS spectrum. All the compounds were evaluated for the inhibitory activity against mTOR kinase at 10 μM level. F...

As a part of our endeavor toward the synthesis of new heterocyclic bioactive agents, two series of thiazolidin-4-one fused s-triazines were synthesized by applying an efficient palladium catalyzed C–C Suzuki coupling using catalyst system Pd(OAC)2, Xphos and K3PO4 as a base in toluene solvent. ...

(Z)-4-(2-(3,5-dibromo-2-hydroxy-4-methoxybenzylidene)hydrazinyl)benzonitrile compound (DHMB) was synthesized by a condensation reaction of 4-cyanophenylhydrazine hydrochloride and 3,5-dibromo-2-hydroxy-4-methoxy benzaldehyde. For characterization of DHMB were used IR, UV visible, LC-MS NMR devic...

A new o-hydroxy Schiff base, (E)-2-[(2-hydroxy-6-methoxybenzylidene)amino]benzonitrile was isolated and investigated by experimental and theoretical methodologies. The solid state molecular structure was determined by X-ray diffraction method. The vibrational spectral analysis was carried out by...

The reaction of CuCl2·2H2O with Schiff base ligand, 4-[(2-hydroxy-3-methoxybenzylidene)amino-1,5-dimethyl-2-phenyl-1H-pyrazol-3-one] (hmdpH), in 1:1 molar ratio led to a novel and unprecedented oxo-bridged polymeric copper (II) complex, [Cu(μ-O) (hmdp)]n. The complex was isolated as crystallin...

In tumor cell lines with high content of DT-diaphorase (EC 1.6.99.2), the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its derivatives is exerted through DT-diaphorase-catalyzed formation of crosslinking species. However, little is known about other possible mechanisms of...