A protonated third-order nonlinear optical crystal, (4-Methoxyphenyl) methanaminium chloride (4MPMAC) has been synthesized by the low-temperature solvent evaporation method. Single crystal X-ray diffraction (SCXRD) analysis reveals the monoclinic crystal system with centrosymmetric space group, ...

Novel 1-amino-4-(ar)alkylaminoanthraquinone derivatives bearing different substituents (Br, CH2OH, CN, or CH3) at the 2-position of the anthraquinone scaffold were synthesized by copper-catalyzed Ullmann condensation. The 2-substituted 1-amino-4-bromoanthraquinone derivatives (bromaminic acid an...

Complex mixtures of natural dimycoloyl diarabinoglycerols isolated from mycobacteria have been shown to be both potent immune signalling agents and potentially valuable antigens in the serodiagnosis of mycobacterial infections. We now report the highly stereocontrolled synthesis of diacyl l-glyc...

This work reports the synthesis of a novel, aspirin-loaded, linear poly (anhydride ester) and provides mechanistic insights into the release of aspirin from this polymer for anti-inflammatory activity. As compared to conventional drug delivery systems that rely on diffusion based release, incorp...

Twenty maslinic acid and corosolic acid derivatives were obtained by coupling with l-amino acids at C-28 position. The α-glucosidase inhibitory activities of the present compounds were evaluated in vitro. Results reveal that some of the derivatives exhibit a better α-glucosidase inhibitory act...

A new pyrrole containing chalcone, ethyl 4-[3-(4-dimethylamino-phenyl)-acryloyl]-3,5-dimethyl-1H-pyrrole-2-carboxylate (EDPADPC) derived from ethyl 4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylate and 4-dimethylamino-benzaldehyde has been characterized by spectroscopic techniques (1H NMR, UV–Visi...

Quinoline is one of the most important heterocyclic systems in life sciences. Some derivatives are normal metabolites, and others are used as antibacterial, antimalarial, and anticancer agents. In this work, we describe the synthesis, physicochemical properties, and fluorescence features of a ne...

3H-[1,2,5]Triazepino[5,4-a]benzimidazol-4(5H)-ones were obtained in five steps involving C-acylation of benzimidazole, its N-alkylation with ethyl bromoacetate, the ester hydrolysis, condensation with BocNHNH2, and the acid-catalyzed heterocyclization of thus obtained 2-(2-aroyl-1H-benzimidazol-...

Polymer-supported Zn-salen (PS-Zn-salen) complexes were synthesized, characterized and used as a catalyst for one-pot oxidative esterification of aldehydes with alcohols. The PS-Zn-salen heterogeneous catalyst exhibited a high-performance for the oxidative esterification of aldehydes to the corr...

In the present investigation we have synthesized a novel series of N-substituted-5-phenyl-1H-pyrazole-4-ethyl carboxylates, which are characterized by 1H NMR, UV–Vis and FT-IR spectroscopy methods. The optical nonlinearity of the compounds in chloroform solution has been studied at 532 nm using...

Wheat straw, a typical lignocellulosic biomass, is difficult to be liquefied because of its complex structure, which limits its further conversion to valuable products. Ionic liquid can dissolve the cellulose, which can destroy the connection of biomass components. Ionic liquids, [BMIM][HSO4], [...

Using a new simi-rigid multitopic ligand 2-(hydroxymethyl)-1H-benzo[d]imidazole-5-carboxylic acid (H2L), seven new coordination polymers [Zn3(L)2(μ2-OH)2]n (1), {[Zn2(HL)2(H2O)2]·SiF6}n (2), [Zn(HL)(SCN)]n (3), {[Zn2(HL)2(SO4)]·(4,4′-bpy)}n (4) [4,4′-bpy =4,4′-bipyridine], {[Zn(HL)2]·2H2O...

A microbial screen identified the yeast Candida sorbophila MY 1833 as a suitable biocatalyst for the asymmetric bioreduction of a ketone (2-(4-nitro-phenyl)-N-(2-oxo-2-pyridin-3-yl-ethyl)-acetamide) to its corresponding (R) alcohol [(R)-N-(2-hydroxy-2-pyridin-3-yl-ethyl)-2-(4-nitro-phenyl)-aceta...

Two new Zn(II) and Cd(II) complexes with the bidentate ligand 2-[(2-aminoethyl)amino]ethanaminium (AEEA), [ZnCl2(C4H14N3)]ClO4 (1) and [CdCl2(C4H14N3)]ClO4 (2), have been prepared and were characterized by single crystal X-ray diffraction, elemental analysis, CP–MAS-NMR and IR spectroscopies. T...

VEGFR, ERK and Abl had been respectively identified as good drug targets, and their crosstalk also had been well elaborated. Multitarget drugs were more advantageous for cancer treatment, however, no inhibitors simultaneously acting on the three proteins were developed due to their structural di...

A novel series of (2-amino)-6-(2-aminoethyl)pyridines were prepared by a convenient Suzuki–Miyaura coupling approach from 2-amino-6-bromopyridines. Benzyl vinylcarbamate was first treated with 9-BBN followed by aqueous NaOH and then the appropriate bromopyridine precursors were added into the m...

Glioblastoma multiforme (GBM) is the worst form of primary brain tumor, which has a high rate of infiltration and resistance to radiation and chemotherapy, resulting in poor prognosis for patients. Recent studies show that thiazolidinones have a wide range of pharmacological properties including...

A new organic nonlinear optical material (4-methylphenyl) (4-methylpiperidin-1-yl) methanone(MPMPM) was synthesized by slow evaporation method using Schotten-Boumann condensation reaction. A single crystal XRD study shows that the compound crystallizes in orthorhombic crystal system with a space...

O-aryl-O, S-dialkylphosphorothioates, such as fully-protected adenylyl(3′→5′)-5′-thiouridine 11, O-aryl-O-ethyl-5′-thiouridyl phosphorothioate 24, upon treatment with an excess n-tetrabutylammononium fluoride in tetrahydrofuran-pyridine-water (8:1:1 v/v/v) underwent a scission of phosphorus...

Bjerkandera adusta produces many chlorometabolites including chlorinated anisyl metabolites (CAMs) and 1-arylpropane-1,2-diols (1, 2, 3, 4) as idiophasic metabolic products of L-phenylalanine. These diols are stereoselectively biosynthesized from a C7-unit (benzylic, from L-phenylalanine) and a ...