This paper reports the synthesis, crystal structure determination and spectroscopic characterization of a new copper (II) complex, [CuCl2(dfpy)2] [dfpy: 2-(2,4-difluorophenyl)pyridine]. The Cu(II) complex crystallizes in triclinic space group P1¯ and the Cu(II) ion lies on a crystallographic in...

The viscosities (η) of CO2-loaded 3-(dimethylamino)propan-1-ol (3DMA1P) aqueous solutions, CO2-unloaded and CO2-loaded 2-(ethylamino)ethanol (EAE)- 3DMA1P aqueous solutions were measured by using the NDJ-5S rotational viscometer. The temperature ranged from 303.2 K to 323.2 K. The mass fraction...

The wavenumbers, molecular structure, molecular electrostatic potential, nonlinear optical properties and natural bond orbital analysis of a thiourea derivative, 1-(3,4-dichlorophenyl)-3-[3-(trifluoromethyl)phenyl]thiourea (ANF-6) were reported. For the title molecule, HOMO is all over the molec...

A facile and environmentally benign synthesis of some 2-(2-oxo-2H-chromen-3-yl)-4-aryl-indeno[1,2-b]pyridine-5-one derivatives from the reaction of aromatic aldehydes, 3-acetylcoumarin, 1,3-indandione and ammonium acetate using phthalimide-N-sulfonic acid (PISA) as a catalyst is described. The p...

The tautomeric properties of an N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide (NTZ-1006, 2) derivative, developed as highly potent, reversible and selective MAO-B inhibitor useful for the treatment of Parkinson's disease (PD) and other neurological disorders, have been studied both exper...

Both ERα and VEGFR-2 are important targets for cancer therapies. Here a series of 2, 4-disubstituted pyrimidine derivatives were designed, synthesized and evaluated as dual ERα/VEGFR-2 ligands. Most of the derivatives exhibited potent activities in both enzymatic and cellular assays. Structure...

Uncatalyzed nucleophilic reaction of 3-formylchromones with tertiary push–pull enamines in refluxing acetonitrile gave polyfunctionalized benzophenone derivatives as a result of a [3+3] annulation in moderate to good yields.

Optically active sulfinylaziridines having a 4-methoxyphenyl group on their nitrogen atom were synthesized from optically active 1-chloroalkyl p-tolyl sulfoxide and an imine derived from benzaldehyde and p-anisidine stereoselectively in good overall yields. The sulfinylaziridines were treated wi...

In this study, graphene oxide-grafted pyridine-based ionic liquids were prepared and used as novel and highly efficient triphase catalysts for the synthesis of benzyl esters by the nucleophilic substitution reaction of benzyl halide with carboxylic acid salt. The as-prepared catalysts were chara...

Oleanolic acid (OA) and glycyrrhetinic acid (GA) are natural products with anticancer effects. Cinnamic acid (CA) and its derivatives also exhibited certain anticancer activity. In order to improve the anticancer activity of OA and GA, we designed and synthesized a series of novel OA-CA ester de...

Potentiometric studies of OBISDIEN in the presence and absence of copper(II) ion and the peptides, glycylglycine, dl-alanyl-dl-alanine and glycyl-l-leucine, were performed. Equilibrium constants for the formation of peptide dinuclear copper(II)-OBISDIEN species are reported. These dinuclear comp...

The conformational features of diethyl 2-[3-{2-(aminocarbonyl)hydrazono}-1-(4-methoxyphenyl)-3-phenylpropyl]malonate are analysed in solid and solution states in the light of the diastereotopic characteristics, and compared with that of {3-[4-(N,N-dimethylamino)phenyl]-1-(4-methylphenyl)-3-(phen...

A N,N-dimethylamino substituted tetraphenylethylene derivative (TPE-NMe) was synthesized and characterized, and was successfully applied as hole transport material (HTM) in perovskite solar cells. The methoxy-substituted analogue TPE-4DPA was also studied for comparison. The effect of replacing ...

The disinfection-induced and photo-induced degradation of the UV filter 3-methylbutyl-(2E)-3-(4-methoxyphenyl)-acrylate (IMC) is investigated. High performance liquid chromatography was used to follow the degradation reactions, determine kinetic features and also the influence of external variab...

The diarylisoxazole molecular scaffold is found in several NSAIDs, especially those with high selectivity for COX-1. Here, we have determined the structural basis for COX-1 binding to two diarylisoxazoles: mofezolac, which is polar and ionizable, and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxa...

3′-Deoxy-3′-fluorokanamycin A (14) has been prepared by condensation of 6-azido-2,4-di-O-benzyl-3,6-dideoxy-3-fluoro-α-d- glucopyranosyl bromide (8) and 6-O-(2-O-acetyl-4,6-O-cyclohexylidene-3-deoxy-3-tosylamino-α-d-glucopyranosyl)-2-deoxy-1,3-di-N- tosylstreptamine (10). Compound 8 was obta...

EGFR and VEGFR-2 are involved in pathological disorders and the progression of different kinds of tumors, the combined blockade of EGFR and VEGFR signaling pathways appears to be an attractive approach to cancer therapy. In this work, a series of 4-anilinoquinazoline derivatives containing subst...

Addition of CF3OF to 3,4-di-O-acetyl-l-fucal gave a 95% yield of two di-O-acetyl-2-deoxy-2-fluoro-l-fucosyl derivatives separable by column chromatography, both in crystalline form. The derivatives were identified by 1H and 19F-NMR to be the α-fluoride and the α-trifluoromethyl-glycoside. Acid...

Summary2-Deoxy-2-fluoro-L-fucose has been obtained as a chromatographically pure compound from 3,4-O-acetyl-L-fucal and its structure established by NMR measurements. Mouse fibroblasts (TAL/N P and TAL/N B) in culture incorporate L-[1-14C-] fucose into glycoproteins of trypsinates and of cell co...

Monoethanolamine (MEA), diethanolamine (DEA), triethanolamine (TEA), methylaminoethanol (MAE), piperidine (PP), pyridine (Pr), morpholine (Mr), diethylamine (DEtA), triethylamine (TEtA), ethylenediamine (EDA), diethylenetriamine (DETA) and triethylenetetramine (TETA) salts of coconut oil acid fr...